Recent progress in synthesis and characterization of metal chalcone complexes and their potential as bioactive agents

Sulpizio, Chiara; Breibeck, Joscha; Rompel, Annette

doi:10.1016/j.ccr.2018.05.023

Cited by 45 publications

(17 citation statements)

References 95 publications

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“…They provide three centres to interact with metals such as functional groups present on aromatic ring, the keto-enol moiety and the olefinic moiety. 11 The heterodiene molecular functionalities form stable complexes with the transition and non-transition elements. 12 In recent years, there have been outstanding developments in several areas of pharmaceutical science.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, characterization, antimicrobial screening and cytotoxic properties of Cu(II) and Zn(II) complexes with bidentate hydroxylated 1,3-diaryl-2-propene-1-ones ligand

Patil¹,

Zangade

2021

JSCS

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A series of binary metal complexes [halo, hydroxyl and methoxy sub-stituted bis (2-(E) acryloyl)naphthalen-1-yl)oxy)Cu(II) and Zn(II) (C1-C10)] of Cu2+ and Zn2+ ions derived from bi-coordinated hydroxylated 1,3-diaryl-2- -propene-1-ones were synthesized. The newly synthesized metal complexes were structurally determined by FT-IR, 1H NMR, 13CNMR, ESR spectral, XRD and TGA analysis. The FT-IR and ESR studies demonstrated that interactions between metal ions with ligands occur through carbonyl oxygen and deprotonated hydroxyl oxygen and corresponds to square-planar geometry for all complexes. In-vitro the metal complexes were screened and evaluated for their antimicrobial and cytotoxic activity. The complexes C1 and C4 showed the significant antimicrobial activity while the remaining complexes were showed the moderately antimicrobial activity against the tested pathogens. The complexes were evaluated for cytotoxic activity against the organism Artemia salina. The complexes C2, C3, C4 and C5 were showed the LC50 values as 630.45, 969.99, 921.94 and 918.41 ?M mL-1 respectively. Further complexes were evaluated for anticancer activity against liver cancer cell line (Hep G2) in comparison with 5-fluorouracil standard. The complex C5 showed the significant IC50 value 58.94 ?g mL-1. Therefore the present study is useful to develop the new class of antimicrobial and anticancer agents.

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Section: Introductionmentioning

confidence: 99%

Synthesis, characterization, antimicrobial screening and cytotoxic properties of Cu(II) and Zn(II) complexes with bidentate hydroxylated 1,3-diaryl-2-propene-1-ones ligand

Patil¹,

Zangade

2021

JSCS

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“…Some chalcone complex supermolecules also showed moderate antibacterial activity against Escherichia coli and Staphylococcus aureus. The octahedral complex proved to inhibit a human rhabdomyosarcoma cell line to nearly the same extent as the cisplatin control, with higher inhibition capacity than the related Cr(III), Fe (III), and Co(II) complexes [38].…”

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confidence: 86%

Supermolecules as Medicinal Drugs

Zhou¹,

Sui²

2019

Handbook of Macrocyclic Supramolecular Assembly

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“…Recently, it has been focused on natural complex agents owing to their good environmental compatibility and biodegradability (Klučáková et al, 2018;Sulpizio et al, 2018). One of the natural complex agents appropriate for the measurement of lead ions is humic acid (Habibul & Chen, 2018;Perelomov et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Determination of lead ions in fish and oyster samples using a nano-adsorbent of functionalized magnetic graphene oxide nanosheets-humic acid and the flame atomic absorption technique

Yekrangi

Benvidi

Jahanbani

et al. 2021

Environ Monit Assess

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This study aims at the functionalization of magnetic graphene oxide nanosheets and the binding of humic acid as a lead complex ligand. Graphene oxide nanosheets possess a large surface area and various carboxylic acid groups which can be activated easily by activating agents. Therefore, they are suitable to be used for the extraction of heavy metals. To have a better process of extracting lead ions, magnetic graphene oxide was used in this research. Humic acid, as a lead metal complex agent, has an amine functional group which can be bound to modified graphene oxide from one side. The process of constructing the nano-adsorbent proposed for the preconcentration of lead ions as well as its characterization was studied by infrared spectroscopy (IR), ultraviolet-visible spectroscopy (UV-visible), field emission scanning electron microscopy (FESEM), and vibrating sample magnetometry (VSM). The designed nano-adsorbent was tested to measure lead ions in simulated and real samples of sea water, fish, and oysters. The detection limit obtained in the simulated samples was 0.07 μg/L, and the linear range was 0.2-12 μg/L. The apparatus used to measure the ions was a flame atomic absorption device. In the analysis of the real samples, the values obtained through

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Recent progress in synthesis and characterization of metal chalcone complexes and their potential as bioactive agents

Cited by 45 publications

References 95 publications

Synthesis, characterization, antimicrobial screening and cytotoxic properties of Cu(II) and Zn(II) complexes with bidentate hydroxylated 1,3-diaryl-2-propene-1-ones ligand

Synthesis, characterization, antimicrobial screening and cytotoxic properties of Cu(II) and Zn(II) complexes with bidentate hydroxylated 1,3-diaryl-2-propene-1-ones ligand

Supermolecules as Medicinal Drugs

Determination of lead ions in fish and oyster samples using a nano-adsorbent of functionalized magnetic graphene oxide nanosheets-humic acid and the flame atomic absorption technique

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