Recent progress in the biology and physiology of BMP-8a

Tang, Jiawei; Tang, Miao; Liao, Siqi; Pang, Mengwei; Li, Jie

doi:10.1080/03008207.2022.2160326

Cited by 4 publications

(2 citation statements)

References 63 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It facilitates comparatively species-specific sperm-oocyte recognition and stimulation of the sperm acrosome reaction. ZP protects the early embryo during its passage within female genital tracts before implantation [56,57]. As ZP demonstrates a strong immunogenicity, it might be a target antigen in ovarian auto-immunity [11,56].…”

Section: Anti-zona Pellucida Antibodies (Azas)mentioning

confidence: 99%

“…ZP protects the early embryo during its passage within female genital tracts before implantation [56,57]. As ZP demonstrates a strong immunogenicity, it might be a target antigen in ovarian auto-immunity [11,56]. The AZAs have been distinguished in fertile and infertile women and men because of their high occurrence [8].…”

Section: Anti-zona Pellucida Antibodies (Azas)mentioning

confidence: 99%

See 1 more Smart Citation

Female Autoimmune Disorders with Infertility: A Narrative Review

Hassan

Al-Tuma

2023

amj

View full text Add to dashboard Cite

Autoimmunity is a condition in which the immune system cannot recognize the self from nonself-antigens. Autoimmunity is relatively more common in females than males. The process of embryo implantation is considered the most significant restricting factor in female reproduction. The immunological system of the females may affect the success or failure of pregnancy by its effect on extremely important steps from ovulation to implantation processes, thus ensuring the importance of autoimmunity for women in sub-fertility. The association between autoimmunity and female reproduction receives increased attention nowadays. A successful conception is a result of multiple complex interactions between the developed embryo and the receptive uterus and is usually under immune-hormonal control. In certain circumstances, the female ovary can be a target of an autoimmune attack, like some organ-specific or systemic autoimmune disorders subsequently resulting in clinically significant ovarian dysfunction, implantation failure, and sub-fertility. Consequently, the effect of a specific auto-antibody on the etiology of infertility remains unknown. This review focused on auto-antibodies that may affect female fertility.

show abstract

Section: Anti-zona Pellucida Antibodies (Azas)mentioning

confidence: 99%

Section: Anti-zona Pellucida Antibodies (Azas)mentioning

confidence: 99%

Female Autoimmune Disorders with Infertility: A Narrative Review

Hassan

Al-Tuma

2023

amj

View full text Add to dashboard Cite

show abstract

Identification of SNPs and candidate genes associated with growth using GWAS and transcriptome analysis in Coilia nasus

Yu,

Wan,

Zhang

et al. 2024

Aquaculture

View full text Add to dashboard Cite

Identification of SUMOylation-related biomarkers in papillary thyroid carcinoma

Li,

Ding,

Tong

2024

Cancer Cell Int

View full text Add to dashboard Cite

Background Small ubiquitin-like modifier (SUMO) modification is increasingly recognized as critical in tumorigenesis and progression. This study identifies biomarkers linked to SUMOylation in papillary thyroid carcinoma (PTC), aiming to advance therapeutic and prognostic strategies. Methods Employing PTC datasets and SUMO related genes (SRGs), we utilized univariate Cox regression for prognosis-related SRGs, conducted differential expression analyses, and integrated findings to pinpoint candidate genes. These genes underwent further validation through survival, gene set enrichment, immune infiltration, and drug sensitivity analyses, including external validation via quantitative RT-qPCR. In our final step, we conducted immunohistochemical staining on tumor samples from PTC patients at our center and integrated this with their clinical data to validate BMP8A’s effectiveness in predicting recurrence in PTC. Results Three biomarkers—BMP8A, RGS8, and SERPIND1—emerged as significant. Gene Set Enrichment Analysis (GSEA) showed their involvement in immune-related pathways, with differential immune infiltration patterns and drug response correlations observed, underscoring their potential for targeted therapy. Lastly, we validated the efficacy of BMP8A in predicting the recurrence of PTC in patients using clinical and pathological data from our center. Conclusion The study identifies BMP8A, RGS8, and SERPIND1 as key biomarkers associated with SUMOylation in PTC. Their linkage to immune response and drug sensitivity highlights their importance as targets for therapeutic intervention and prognosis in PTC research.

show abstract

Recent progress in the biology and physiology of BMP-8a

Cited by 4 publications

References 63 publications

Female Autoimmune Disorders with Infertility: A Narrative Review

Female Autoimmune Disorders with Infertility: A Narrative Review

Identification of SNPs and candidate genes associated with growth using GWAS and transcriptome analysis in Coilia nasus

Identification of SUMOylation-related biomarkers in papillary thyroid carcinoma

Contact Info

Product

Resources

About