Recent Progress in Urothelial Bladder Carcinoma: Basic Biology, Molecular Characterization, Conventional and Innovative Therapies and Tumour–Stroma Interactions

Hatina, Jiřı́; Kripnerová, Michaela; Houfkova, Katerina; Hajdůšková, Martina; Navvabi, Nazila; Havlíčková, Natálie; Pešta, Martin

doi:10.1007/16833_2022_83

Cited by 2 publications

(2 citation statements)

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“…In this case, the 7β-estradiol-bound estrogen receptor inhibits IKK activity and causes IκB protein degradation, blocking DNA binding by NF-κB. Consequently, this leads to a reduction in the intensity of the inflammatory response during the course of various diseases, including cancer [ 47 , 48 , 49 ]. Moreover, we also observed a significant increase in the expression of IL-6 in the case of the T1 stage compared to the Ta stage.…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, high levels of IL-8 secretion in peripheral blood leukocytes was significantly associated with shorter recurrence-free survival in patients with bladder cancer receiving Bacillus Calmette–Guerin (BCG) therapy. Similarly, high baseline urinary IL-8 levels were also predictive of shorter time to tumour recurrence in NMIBC patients [ 47 ]. However, in the presented study, we found significantly decreased IL-8 expression in BC patients compared to controls.…”

Section: Discussionmentioning

confidence: 99%

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Variability, Expression, and Methylation of IL-6 and IL-8 Genes in Bladder Cancer Pathophysiology

Grębowski

Saluk‐Bijak

Bijak

et al. 2023

IJMS

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Bladder cancer (BC) is the 10th most common form of cancer globally, but its complete aetiology is still unknown. Nevertheless, there is evidence that chronic inflammation plays a role in the development and progression of BC. Therefore, the presented study aimed to detect a potential association between selected single nucleotide polymorphisms (SNPs)—rs1800797 and rs2069845 in IL-6 and rs2227307 in IL-8—and BC development, as well as to identify the impact of BC on the level of expression and methylation of IL-6 and IL-8 promoters in PBMCs with the use of the TaqMan SNP genotyping assay, TaqMan gene expression assay, and methylation-sensitive high-resolution melting techniques. We did not find any association between the genotypes and combined genotypes of all studied polymorphisms and the occurrence of BC. However, we found that BC patients were characterised by decreased IL-6 and IL-8 mRNA expression levels compared to the controls. Additionally, the methylation status of the IL-6 promoter was higher in controls than in BC patients. Our findings suggest that inflammation may be involved in the development and progression of BC.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%