Objective: To use the method of network pharmacology to predict the mechanism of Crataegi fructus hypoglycemic and lipid regulation and its pharmacodynamic material basis. Methods: Traditional Chinese Medicine Systems Pharmacolog Database (TCMSP), Traditional Chinese Medicine Integrative Database (TCMID), Bioinformatics Analysis Tool for Molecular mechanism (BATMAN), and GeneCards databases were used to mine the active components of Crataegi fructus and their targets for hypoglycemic and lipid-lowering.