Recent progress of collagen, chitosan, alginate and other hydrogels in skin repair and wound dressing applications

Wei, Peng; Li, Dan; Dai, Kaili; Wang, Yixi; Song, Ping; Li, Hairui; Tang, Pei; Zhang, Zhenyu; Li, Zhengyong; Zhou, Yuchi; Zhou, Changchun

doi:10.1016/j.ijbiomac.2022.03.002

Cited by 228 publications

(125 citation statements)

References 94 publications

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“…44 Polymers used in the manufacture of dressings can be natural, such as chitosan, gelatin and sodium alginate, or synthetic, such as polyvinyl alcohol, polyacrylic acid, polycaprolactone, and polyethylene glycol. 45 In addition, different formulations can be used as dressings, from semi-solid forms (hydrogels, creams, and ointments) to controlled release matrix systems (membranes, sponges, and films).…”

Section: Wound Dressingmentioning

confidence: 99%

“…The main advantages are easy removal and application on the wound bed, but maceration in wounds can occur which impedes the healing process. 45 Foam dressings are mainly composed of polyurethane and frequently used due to their ability to absorb exudate. These dressings are not indicated for dry wounds or eschars treatment, because they can adhere to the wound bed causing pain and secondary wounds.…”

Section: Wound Dressingmentioning

confidence: 99%

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Alginate/polyvinyl alcohol films for wound healing: Advantages and challenges

et al. 2022

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The skin is the largest organ in the human body and its physical integrity must be maintained for body homeostasis and to prevent the entry of pathogenic microorganisms. Sodium alginate (SA) and polyvinyl alcohol (PVA) are two polymers widely used in films for wound dressing applications. Furthermore, blends between SA and PVA improve physical, mechanical and biological properties of the final wound healing material when compared to the individual polymers. Different drugs have been incorporated into SA/PVA-based films to improve wound healing activity. It is noteworthy that SA/PVA films can be crosslinked with Ca 2+ or other agents, which improves physicochemical and biological properties. Thus, SA/PVA associations are promising for the biomedical field, as a potential alternative for wound treatment. This review focuses on the main techniques for obtaining SA/PVA films, their physical-chemical characterization, drug incorporation, and the advantages and challenges of these films for wound healing.

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Section: Wound Dressingmentioning

confidence: 99%

Section: Wound Dressingmentioning

confidence: 99%

Alginate/polyvinyl alcohol films for wound healing: Advantages and challenges

et al. 2022

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“…In addition, mortality from chronic wounds is even said to be comparable to cancers ( Las Heras et al, 2020 ). Challenges such as limitations in autologous tissues and skin donors and the severity and extent of injuries, damage, and scar contracture in the area of the skin grafts, further exacerbate and complicate the issue ( Peng et al, 2022 ). Propolis has been shown to have wound-healing and antimicrobial properties which make it a suitable component to be incorporated into biomaterials for wound and/or skin dressing purposes ( da Silva et al, 2020 ).…”

Section: Skin Dressing-related Biomaterialsmentioning

confidence: 99%

The Suitability of Propolis as a Bioactive Component of Biomaterials

Lesmana

Zulhendri

Fearnley³

et al. 2022

Front. Pharmacol.

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Propolis is a resinous product collected by bees from plant exudates to protect and maintain hive homeostasis. Propolis has been used therapeutically for centuries as folk medicine. Modern research investigating the diversity of the chemical composition and plant sources, biological activity, extraction processes, analytical methods, and therapeutic properties in clinical settings have been carried out extensively since the 1980s. Due to its antimicrobial, anti-inflammatory, and immuno-modulator properties, propolis appears to be a suitable bioactive component to be incorporated into biomaterials. This review article attempts to analyze the potential application of propolis as a biomaterial component from the available experimental evidence. The efficacy and compabitility of propolis depend upon factors, such as types of extracts and types of biomaterials. Generally, propolis appears to be compatible with hydroxyapatite/calcium phosphate-based biomaterials. Propolis enhances the antimicrobial properties of the resulting composite materials while improving the physicochemical properties. Furthermore, propolis is also compatible with wound/skin dressing biomaterials. Propolis improves the wound healing properties of the biomaterials with no negative effects on the physicochemical properties of the composite biomaterials. However, the effect of propolis on the glass-based biomaterials cannot be generalized. Depending on the concentration, types of extract, and geographical sources of the propolis, the effect on the glass biomaterials can either be an improvement or detrimental in terms of mechanical properties such as compressive strength and shear bond strength. In conclusion, two of the more consistent impacts of propolis across these different types of biomaterials are the enhancement of the antimicrobial and the immune-modulator/anti-inflammatory properties resulting from the combination of propolis and the biomaterials.

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“…Over time, newer wound dressing materials have been developed to provide appropriate care for wounds and ensure optimal healing (48). Apart from chitosan, as previously described, collagen (49), alginate (50), cellulose (51), gelatin (52), hyaluronic acid (53), silk (54), and foam dressings (55) have been extensively studied in the field of skin wound dressings. In recent years, 10.3389/fmed.2022.947649…”

Section: Research Focusesmentioning

confidence: 99%

Deciphering the focuses and trends in skin regeneration research through bibliometric analyses

Zhou

Chen²,

Shu³

et al. 2022

Front. Med.

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Increasing attention to skin regeneration has rapidly broadened research on the topic. However, no bibliometric analysis of the field’s research trends has yet been conducted. In response to this research gap, this study analyzed the publication patterns and progress of skin regeneration research worldwide using a bibliometric analysis of 1,471 papers comprising 1,227 (83.4%) original articles and 244 (16.6%) reviews sourced from a Web of Science search. Publication distribution was analyzed by country/region, institution, journal, and author. The frequency of keywords was assessed to prepare a bibliometric map of the development trends in skin regeneration research. China and the United States were the most productive countries in the field: China had the greatest number of publications at 433 (29.4%) and the United States had the highest H-index ranking (59 with 15,373 citations or 31.9%). Author keywords were classified into four clusters: stem cell, biomaterial, tissue engineering, and wound dressing. “Stem cells,” “chitosan,” “tissue engineering,” and “wound dressings” were the most frequent keywords in each cluster; therefore, they reflected the field’s current focus areas. “Immunomodulation,” “aloe vera,” “extracellular vesicles,” “injectable hydrogel,” and “three-dimensional (3D) bioprinting” were relatively new keywords, indicating that biomaterials for skin regeneration and 3D bioprinting are promising research hotspots in the field. Moreover, clinical studies on new dressings and techniques to accelerate skin regeneration deserve more attention. By uncovering current and future research hotspots, this analysis offers insights that may be useful for both new and experienced scholars striving to expand research and innovation in the field of skin regeneration.

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Recent progress of collagen, chitosan, alginate and other hydrogels in skin repair and wound dressing applications

Cited by 228 publications

References 94 publications

Alginate/polyvinyl alcohol films for wound healing: Advantages and challenges

Alginate/polyvinyl alcohol films for wound healing: Advantages and challenges

The Suitability of Propolis as a Bioactive Component of Biomaterials

Deciphering the focuses and trends in skin regeneration research through bibliometric analyses

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