Recent progress of microfluidic technology for pharmaceutical analysis

Jia, Xiaomeng; Yang, Xiaoping; Luo, Guangsheng; Liang, Qionglin

doi:10.1016/j.jpba.2021.114534

Cited by 20 publications

(14 citation statements)

References 190 publications

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“…Microfluidic chips have been defined as the establishment of chemical or biological laboratories on a few square centimeters of chips (Bhatia & Ingber, 2014). Because the concept of microfluidic chips was proposed in the early 1990s, microfluidic chips have shown great potential in the investigation of basic mechanisms of organ physiology and toxicity (Ai et al, 2019, 2020; Jia et al, 2022; Wang et al, 2021). Moreover, the advantages such as good portability, low cost, and small reagent consumption (McCormick et al, 2017; Medina‐Sanchez et al, 2012) make them a good choice for rapid, real‐time, and multi‐sample analysis (Shah et al, 2014).…”

Section: Emerging Models For Nps Toxicity Testingmentioning

confidence: 99%

Section: In Vitro Models On Microfluidic Devicesmentioning

confidence: 99%

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Toxicity of transition metal nanoparticles: A review of different experimental models in the gastrointestinal tract

Wang

Gao

et al. 2022

J of Applied Toxicology

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The development of nanotechnology is becoming a major trend nowadays.Nanoparticles (NPs) have been widely used in fields including food, biomedicine, and cosmetics, endowing NPs more opportunities to enter the human body. It is wellknown that the gut microbiome plays a key role in human health, and the exposure of intestines to NPs is unavoidable. Accordingly, the toxicity of NPs has attracted more attention than before. This review mainly highlights recent advances in the evaluation of NPs' toxicity in the gastrointestinal system from the existing cell-based experimental models, such as the original mono-culture models, co-culture models, three-dimensional (3D) culture models, and the models established on microfluidic chips, to those in vivo experiments, such as mice models, Caenorhabditis elegans models, zebrafish models, human volunteers, as well as computer-simulated toxicity models. Owing to these models, especially those more biomimetic models, the outcome of the toxicity of NPs acting in the gastrointestinal tract can get results closer to what happened inside the real human microenvironment.

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Section: Emerging Models For Nps Toxicity Testingmentioning

confidence: 99%

Section: In Vitro Models On Microfluidic Devicesmentioning

confidence: 99%

Toxicity of transition metal nanoparticles: A review of different experimental models in the gastrointestinal tract

Wang

Gao

et al. 2022

J of Applied Toxicology

Self Cite

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“…However, the application of these devices was limited by their complexity, high production cost, toxic byproducts, difficulty in mixing multiple components, and restricted gas permeability. Later on, soft lithography for chip production emerged, and microfluidic technology entered a period of rapid development [ 25 , 26 ]. Soft lithography enables the fabrication of various polymer-based microfluidic devices.…”

Section: Microfluidicsmentioning

confidence: 99%

“…Droplet microfluidics is one of the most prevalent techniques for encapsulating single cells; single-cell droplets are suitable for high-throughput screening and sorting. As they can circumvent the average population and make room for intercellular heterogeneity, single-cell microarrays have become the preferred tool for the screening of potential drugs [ 15 , 25 , 42 , 43 , 44 , 45 ].…”

Section: Microfluidicsmentioning

confidence: 99%

Application of Microfluidics in Drug Development from Traditional Medicine

Li¹,

Fan

et al. 2022

Biosensors

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While there are many clinical drugs for prophylaxis and treatment, the search for those with low or no risk of side effects for the control of infectious and non-infectious diseases is a dilemma that cannot be solved by today’s traditional drug development strategies. The need for new drug development strategies is becoming increasingly important, and the development of new drugs from traditional medicines is the most promising strategy. Many valuable clinical drugs have been developed based on traditional medicine, including drugs with single active ingredients similar to modern drugs and those developed from improved formulations of traditional drugs. However, the problems of traditional isolation and purification and drug screening methods should be addressed for successful drug development from traditional medicine. Advances in microfluidics have not only contributed significantly to classical drug development but have also solved many of the thorny problems of new strategies for developing new drugs from traditional drugs. In this review, we provide an overview of advanced microfluidics and its applications in drug development (drug compound synthesis, drug screening, drug delivery, and drug carrier fabrication) with a focus on its applications in conventional medicine, including the separation and purification of target components in complex samples and screening of active ingredients of conventional drugs. We hope that our review gives better insight into the potential of traditional medicine and the critical role of microfluidics in the drug development process. In addition, the emergence of new ideas and applications will bring about further advances in the field of drug development.

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“…In the pharmaceutical, field OoC is used to identify and detect different drug molecules both in quantity and quality. Some of the limitations of the pharmaceutical analysis have been removed giving access to more applications such as drug screening, drug quality control and precision medicine ( Jia et al, 2022 ).…”

Section: Introductionmentioning

confidence: 99%

Organ-On-A-Chip: A Survey of Technical Results and Problems

Danku

Dulf

Braicu

et al. 2022

Front. Bioeng. Biotechnol.

103

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Organ-on-a-chip (OoC), also known as micro physiological systems or “tissue chips” have attracted substantial interest in recent years due to their numerous applications, especially in precision medicine, drug development and screening. Organ-on-a-chip devices can replicate key aspects of human physiology, providing insights into the studied organ function and disease pathophysiology. Moreover, these can accurately be used in drug discovery for personalized medicine. These devices present useful substitutes to traditional preclinical cell culture methods and can reduce the use of in vivo animal studies. In the last few years OoC design technology has seen dramatic advances, leading to a wide range of biomedical applications. These advances have also revealed not only new challenges but also new opportunities. There is a need for multidisciplinary knowledge from the biomedical and engineering fields to understand and realize OoCs. The present review provides a snapshot of this fast-evolving technology, discusses current applications and highlights advantages and disadvantages for biomedical approaches.

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Recent progress of microfluidic technology for pharmaceutical analysis

Cited by 20 publications

References 190 publications

Toxicity of transition metal nanoparticles: A review of different experimental models in the gastrointestinal tract

Toxicity of transition metal nanoparticles: A review of different experimental models in the gastrointestinal tract

Application of Microfluidics in Drug Development from Traditional Medicine

Organ-On-A-Chip: A Survey of Technical Results and Problems

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