Recent Progress of the Preparation and Application of Electrospun Porous Nanofibers

Wang, Pu; Lv, He; Cao, Xianyang; Liu, Yanan; Yu, Deng‐Guang

doi:10.3390/polym15040921

Cited by 56 publications

(45 citation statements)

References 197 publications

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“…Electrospinning is popular for creating nanofibers of polymers. Later, attention shifted to fabricating complex structures and treating unspinnable fluids [ 70 , 71 , 72 ]. Deposited nanofibers can also be organized to prepare functional fiber films [ 73 ].…”

Section: Resultsmentioning

confidence: 99%

A Sequential Electrospinning of a Coaxial and Blending Process for Creating Double-Layer Hybrid Films to Sense Glucose

Yang

Kang

et al. 2023

Sensors

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This study presents a glucose biosensor based on electrospun core–sheath nanofibers. Two types of film were fabricated using different electrospinning procedures. Film F1 was composed solely of core–sheath nanofibers fabricated using a modified coaxial electrospinning process. Film F2 was a double-layer hybrid film fabricated through a sequential electrospinning and blending process. The bottom layer of F2 comprised core–sheath nanofibers fabricated using a modified process, in which pure polymethacrylate type A (Eudragit L100) was used as the core section and water-soluble lignin (WSL) and phenol were loaded as the sheath section. The top layer of F2 contained glucose oxidase (GOx) and gold nanoparticles, which were distributed throughout the polyvinylpyrrolidone K90 (PVP K90) nanofibers through a single-fluid blending electrospinning process. The study investigated the sequential electrospinning process in detail. The experimental results demonstrated that the F2 hybrid film had a higher degradation efficiency of β-D-glucose than F1, reaching a maximum of over 70% after 12 h within the concentration range of 10–40 mmol/L. The hybrid film F2 is used for colorimetric sensing of β-D-glucose in the range of 1–15 mmol/L. The solution exhibited a color that deepened gradually with an increase in β-D-glucose concentration. Electrospinning is flexible in creating structures for bio-cascade reactions, and the double-layer hybrid film can provide a simple template for developing other sensing nanomaterials.

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Section: Resultsmentioning

confidence: 99%

A Sequential Electrospinning of a Coaxial and Blending Process for Creating Double-Layer Hybrid Films to Sense Glucose

Yang

Kang

et al. 2023

Sensors

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“…Today, electrospinning, as a useful nanofiber fabrication method, has spread into almost all scientific applied fields ( Pang et al, 2021 ; Li et al, 2022 ; Wang et al, 2023 ; Wang et al, 2023 ; Geesi et al, 2023 ), including several biomedical applications, such as tissue engineering, regeneration medicine, and wound dressing ( Khazaeli et al, 2020 ; Niu et al, 2021b ; Li et al, 2021 ; Maleki et al, 2021 ; Zhao H. et al, 2022 ; Gao et al, 2022 ; Liang et al, 2022 ). Particularly in pharmaceutics, it is regarded as a popular pharmaceutical nanotechnology ( Spizzirri et al, 2021 ; Chen et al, 2022 ; Wang et al, 2022 ).…”

Section: Introductionmentioning

confidence: 99%

Fast and convenient delivery of fluidextracts liquorice through electrospun core-shell nanohybrids

Liu

Dai

et al. 2023

Front. Bioeng. Biotechnol.

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Introduction: As an interdisciplinary field, drug delivery relies on the developments of modern science and technology. Correspondingly, how to upgrade the traditional dosage forms for a more efficacious, safer, and convenient drug delivery poses a continuous challenge to researchers.Methods, results and discussion: In this study, a proof-of-concept demonstration was conducted to convert a popular traditional liquid dosage form (a commercial oral compound solution prepared from an intermediate licorice fluidextract) into a solid dosage form. The oral commercial solution was successfully encapsulated into the core–shell nanohybrids, and the ethanol in the oral solution was removed. The SEM and TEM evaluations showed that the prepared nanofibers had linear morphologies without any discerned spindles or beads and an obvious core–shell nanostructure. The FTIR and XRD results verified that the active ingredients in the commercial solution were compatible with the polymeric matrices and were presented in the core section in an amorphous state. Three different types of methods were developed, and the fast dissolution of the electrospun core–shell nanofibers was verified.Conclusion: Coaxial electrospinning can act as a nano pharmaceutical technique to upgrade the traditional oral solution into fast-dissolving solid drug delivery films to retain the advantages of the liquid dosage forms and the solid dosage forms.

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“…Combining electrospinning with polymer phase separation techniques enables the fabrication of individual electrospun porous nanofibers . Among the various phase separation mechanisms, nonsolvent-induced phase separation (NIPS) emerged as a straightforward and practical method for generating electrospun porous nanofibers . One strategy involves incorporating a nonsolvent to form a polymer/solvent/nonsolvent ternary system.…”

Section: Introductionmentioning

confidence: 99%

“…Second, controlling the solvent quantity in real-time during electrospinning remains a hurdle. Finally, when electrospinning polymers into a nonsolvent bath, loosely aggregated nanofibers are typically generated, which may be unsuitable for numerous applications that necessitate flat, nonwoven membranes, such as filtration. ,− …”

Section: Introductionmentioning

confidence: 99%

Advancing Nanofiber Research: Assessing Nonsolvent Contributions to Structure Using Coaxial Electrospinning

Wei,

Wildy,

et al. 2023

Langmuir

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In this study, we explored the influence of molecular interactions and solvent evaporation kinetics on the formation of porous structures in electrospun nanofibers, utilizing polyacrylonitrile (PAN) and polystyrene (PS) as model polymers. The coaxial electrospinning technique was employed to control the injection of water and ethylene glycol (EG) as nonsolvents into polymer jets, demonstrating its potential as a powerful tool for manipulating phase separation processes and fabricating nanofibers with tailored properties. Our findings highlighted the critical role of intermolecular interactions between nonsolvents and polymers in governing phase separation and porous structure formation. Additionally, we observed that the size and polarity of nonsolvent molecules affected the phase separation process. Furthermore, solvent evaporation kinetics were found to significantly impact phase separation, as evidenced by less distinct porous structures when using a rapidly evaporating solvent like tetrahydrofuran (THF) instead of dimethylformamide (DMF). This work offers valuable insights into the intricate relationship between molecular interactions and solvent evaporation kinetics during electrospinning, providing guidance for researchers developing porous nanofibers with specific characteristics for various applications, including filtration, drug delivery, and tissue engineering.

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Recent Progress of the Preparation and Application of Electrospun Porous Nanofibers

Cited by 56 publications

References 197 publications

A Sequential Electrospinning of a Coaxial and Blending Process for Creating Double-Layer Hybrid Films to Sense Glucose

A Sequential Electrospinning of a Coaxial and Blending Process for Creating Double-Layer Hybrid Films to Sense Glucose

Fast and convenient delivery of fluidextracts liquorice through electrospun core-shell nanohybrids

Advancing Nanofiber Research: Assessing Nonsolvent Contributions to Structure Using Coaxial Electrospinning

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