Recent progress on bioimaging strategies based on Janus nanoparticles

Li, Zheyi; Gao, Zhiqiang; Zou, Dan-Qing; Zhou, Huan; Yi, Yang; Wang, Jun; Wang, Lei

doi:10.1039/d2nr03186h

Cited by 10 publications

(2 citation statements)

References 56 publications

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“…Detection and quantification of biologically important species are becoming important for treating infections and diseases existing in living systems [ 1 , 2 , 3 ]. Therefore, bioimaging of these affected tissues or cells was proposed by using fluorescent organic nanoparticles, inorganic nanostructures, hybrid nanosystems, and composites with authenticated evidence [ 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 ]. Among these biologically important species, non-protein biothiols, such as cysteine (Cys; normal blood plasma concentration is between 135 to 300 µM), homocysteine (Hcy; normal blood plasma concentration is between 5 to 15 µM), and glutathione (GSH normal blood plasma concentration is between 1 to 6 µM), play a vital role in many pathological process, clinical disorders, and diseases [ 14 , 15 , 16 ].…”

Section: Introductionmentioning

confidence: 99%

Review on Carbon Dot-Based Fluorescent Detection of Biothiols

Shellaiah

Sun

2023

Biosensors

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Biothiols, such as cysteine (Cys), homocysteine (Hcy), and glutathione (GSH), play a vital role in gene expression, maintaining redox homeostasis, reducing damages caused by free radicals/toxins, etc. Likewise, abnormal levels of biothiols can lead to severe diseases, such as Alzheimer’s disease (AD), neurotoxicity, hair depigmentation, liver/skin damage, etc. To quantify the biothiols in a biological system, numerous low-toxic probes, such as fluorescent quantum dots, emissive organic probes, composited nanomaterials, etc., have been reported with real-time applications. Among these fluorescent probes, carbon-dots (CDs) have become attractive for biothiols quantification because of advantages of easy synthesis, nano-size, crystalline properties, low-toxicity, and real-time applicability. A CDs-based biothiols assay can be achieved by fluorescent “Turn-On” and “Turn-Off” responses via direct binding, metal complex-mediated detection, composite enhanced interaction, reaction-based reports, and so forth. To date, the availability of a review focused on fluorescent CDs-based biothiols detection with information on recent trends, mechanistic aspects, linear ranges, LODs, and real applications is lacking, which allows us to deliver this comprehensive review. This review delivers valuable information on reported carbon-dots-based biothiols assays, the underlying mechanism, their applications, probe/CDs selection, sensory requirement, merits, limitations, and future scopes.

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Section: Introductionmentioning

confidence: 99%

Review on Carbon Dot-Based Fluorescent Detection of Biothiols

Shellaiah

Sun

2023

Biosensors

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“…The Janus material with a heterogeneous structure of two different components compartmentalized onto the same surface allows different types of chemical reactions. [16][17][18] The directed forces or selective reactions endow it with unique properties for application in surfactants, sensors, drug carriers, displays, coatings, self-propelled carriers or probes. 19,20 For example, biphasic Janus self-propelled hemostatic particles (MSN@CaCO 3 ) were powered by the internal component of CaCO 3 to enter deep bleeding sites and induce synergistic coagulation to effectively stop bleeding.…”

Section: Introductionmentioning

confidence: 99%

Sheet-like Janus hemostatic dressings with synergistic effects of cardanol hemostasis and quaternary ammonium salt antibacterial action

Zhang

Chi

et al. 2022

J. Mater. Chem. B

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Silica‐Stabilized Lead Halide Perovskite Nanocrystals: Advantages, Progress, and Future Directions

Miao,

Xie,

Kan

et al. 2024

Advanced Optical Materials

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Lead halide perovskite nanocrystals (PNCs) combine properties required by high‐quality light sources like high brightness, color purity, defects tolerance, and tunable emission wavelength. Notably, their nanoscale size enables integration or fabrication into micro/nano light‐emitting devices, which have significant market demand. However, the stability of PNCs remains an open issue for their industrialization. Chemically stable and transparent amorphous silica (SiO2), an ideal cladding for vulnerable optical materials, is widely utilized to expand the applications of PNCs, resulting in many composites. Nevertheless, current composites remain far from achieving a sufficiently stable high‐quality luminescent unit, and the specific challenges in PNCs‐SiO2 integration have not been clearly outlined. To provide inspiration for this field, iodine‐containing PNCs are used as a representative example to deliver a comprehensive review of PNCs‐SiO2 development. First, the performance advantages, prospects, and stability challenges of PNCs are analyzed, with a focus on typical cesium lead iodine nanocrystals. Next, the benefits of SiO2 encapsulation are highlighted and the design, synthesis, and performance improvement of current iodine‐containing PNCs‐SiO2 composites are systematically summarized. Finally, optimism about the potential of single‐particle encapsulation technology for PNCs is expressed and the challenges and future directions in this field are outlined.

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Recent progress on bioimaging strategies based on Janus nanoparticles

Abstract: Janus nanoparticles refer to a kind of asymmetric-structured nanoparticles that composed of two or more distinct sides with differences in chemical nature and/or polarity on each side, thus can integrate...

Cited by 10 publications

References 56 publications

Review on Carbon Dot-Based Fluorescent Detection of Biothiols

Review on Carbon Dot-Based Fluorescent Detection of Biothiols

Sheet-like Janus hemostatic dressings with synergistic effects of cardanol hemostasis and quaternary ammonium salt antibacterial action

Silica‐Stabilized Lead Halide Perovskite Nanocrystals: Advantages, Progress, and Future Directions

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