Recent Progress on Bioresorbable Passive Electronic Devices and Systems

Abstract

Bioresorbable electronic devices and/or systems are of great appeal in the field of biomedical engineering due to their unique characteristics that can be dissolved and resorbed after a predefined period, thus eliminating the costs and risks associated with the secondary surgery for retrieval. Among them, passive electronic components or systems are attractive for the clear structure design, simple fabrication process, and ease of data extraction. This work reviews the recent progress on bioresorbable passive electronic devices and systems, with an emphasis on their applications in biomedical engineering. Materials strategies, device architectures, integration approaches, and applications of bioresorbable passive devices are discussed. Furthermore, this work also overviews wireless passive systems fabricated with the combination of various passive components for vital sign monitoring, drug delivering, and nerve regeneration. Finally, we conclude with some perspectives on future fundamental studies, application opportunities, and remaining challenges of bioresorbable passive electronics.

Controlling the lifetime of biodegradable electronics: from dissolution kinetics to trigger acceleration

“…Several natural polymers, including proteins (silk [108][109][110] and collagen [111][112][113] ) and polysaccharides (chitosan [114] and starch [22,115] ), or synthetic polymers, such as poly(lactic-co-glycolic acid) (PLGA) [22,[116][117][118] , are some examples of commonly used polymers for encapsulation [1,7,70,75,94,95,106] . Such polymers draw attention due to their biocompatible nature, water solubility, tunable dissolution rate, and mechanical properties for their use as transient water barriers [70,75,95,97] .…”

Biodegradable polymeric materials for flexible and degradable electronics

“…Biodegradable therapeutic devices have gained tremendous momentum in the last decade, thanks to advances in modulation processes and novel processing technologies for flexible, stretchable degradable materials (Long et al, 2018;Cha et al, 2019;La Mattina et al, 2020;Wei et al, 2021). In 2014, Omenetto and colleagues demonstrated a programmable transient thermal therapy system for surgical site disinfection and anti-infection using a silk substrate and encapsulation with magnesium metal as the heating resistor (Figure 7A) (Tao et al, 2014).…”

Bioresorbable Nanostructured Chemical Sensor for Monitoring of pH Level In Vivo

“…To the best of our knowledge, no demonstration of in vivo operation of bioresorbable chemical or pH sensors has been given to date. [ 2 , 23 ]…”

“…To the best of our knowledge, no demonstration of in vivo operation of bioresorbable chemical or pH sensors has been given to date. [2,23] Among the many analytes of clinical interest, the concentration of H + , that is, the pH value, is of utmost importance for acidbase regulation. [24][25][26] The concentration of H + in blood plasma and various other body fluids is among the most tightly regulated variables in human physiology.…”