Recent progress on chikungunya virus research

An, Wenxi; Ge, Nannan; Cao, Yang; Jin, Sun Woo; Jin, Xia

doi:10.1007/s12250-017-4072-x

Cited by 19 publications

(16 citation statements)

References 94 publications

(109 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Las técnicas serológicas tienen eficacias variables, en términos de sensibilidad y especificidad. Pueden existir falsas serologías positivas por reacción cruzada entre Alphavirus [63] .…”

Section: Diagnóstico Biológico Del Chikungunyaunclassified

Conducta práctica ante un niño febril al regresar de un viaje

Minodier

Imbert

2019

EMC - Pediatría

View full text Add to dashboard Cite

Las enfermedades más frecuentes al regresar de un viaje al extranjero son las infecciones gastrointestinales, las enfermedades febriles y los problemas dermatológicos. La evaluación de un niño febril al regreso de un viaje es clínica: verificación de los antecedentes y las vacunaciones, búsqueda de otros casos en contacto, signos funcionales y físicos, y características del viaje. Unas pruebas complementarias de rutina completan a menudo la evaluación para una orientación sindrómica. Si bien las causas de fiebre son, sobre todo, cosmopolitas, la gravedad de la enfermedad exótica obliga a buscarlas prioritariamente. El paludismo debe sospecharse ante una fiebre procedente de África subsahariana. El diagnóstico se basa en la asociación de un frotis sanguíneo y una prueba sensible (gota gruesa, reacción en cadena de la polimerasa [PCR]) o una prueba de diagnóstico rápido (para Plasmodium falciparum). Los criterios clínico-biológicos de gravedad son esenciales para orientar y tratar al paciente. En caso de acceso no complicado por P. falciparum, el tratamiento se basa en un tratamiento combinado a base de artemisinina (ACT), arteméter-lumefantrina o artenimol-piperaquina. Los accesos graves se tratan con artesunato intravenoso, seguido de ACT oral. Dengue, chikungunya e infección por virus Zika tienen características clínicas comunes (fiebre-erupción-artralgias, tratamiento sintomático). En caso de dengue, conviene controlar la aparición de signos de alerta, que podrían hacer temer una evolución negativa. El chikungunya es grave en caso de transmisión en el parto, con un riesgo de encefalitis neonatal. En el niño, el Zika es asintomático o poco sintomático. Pero, en caso de infección durante el embarazo, el riesgo es el de una embriofetopatía. El diagnóstico de estas arbovirosis se basa en la PCR en la fase aguda y en la serología secundariamente. La sintomatología de la fiebre tifoidea es poco específica, lo cual justifica la práctica de hemocultivos sistemáticos ante una fiebre tras un viaje. Su tratamiento se basa en las cefalosporinas de tercera generación o el ciprofloxacino, pero las resistencias aumentan. En suma, la diversidad de las etiologías de una fiebre al regreso de un viaje y la potencial gravedad de las infecciones importadas imponen una reflexión sobre el proceso de tratamiento de estos pacientes, en especial en lo referente al riesgo de fiebre hemorrágica. © 2019 Elsevier Masson SAS. Todos los derechos reservados.Conducta práctica ante un niño febril al regresar de un viaje 2 EMC -Pediatría Conducta práctica ante un niño febril al regresar de un viaje E -4-320-A-20

show abstract

Section: Diagnóstico Biológico Del Chikungunyaunclassified

Conducta práctica ante un niño febril al regresar de un viaje

Minodier

Imbert

2019

EMC - Pediatría

View full text Add to dashboard Cite

show abstract

“…Chikungunya virus (CHIKV) is an alphavirus of the Togaviridae family, that is transmitted by the bite of mosquitoes of the species Aedes aegypti and A . albopictus 1 . CHIKV is considered a public health problem due to its rapid spread and high morbidity 2 .…”

Section: Introductionmentioning

confidence: 99%

“…CHIKV is considered a public health problem due to its rapid spread and high morbidity 2 . It causes a febrile illness accompanied by maculopapular rash and severe joint pain that can last for months or years 1 . The incapacitating nature of the disease has caused a substantial economic burden and collapse in health systems 1 .…”

Section: Introductionmentioning

confidence: 99%

“…It causes a febrile illness accompanied by maculopapular rash and severe joint pain that can last for months or years 1 . The incapacitating nature of the disease has caused a substantial economic burden and collapse in health systems 1 . The local transmission of CHIKV has been reported in more than 100 countries and territories in Asia, Africa, Europe, and the Americas 1 .…”

Section: Introductionmentioning

confidence: 99%

“…The incapacitating nature of the disease has caused a substantial economic burden and collapse in health systems 1 . The local transmission of CHIKV has been reported in more than 100 countries and territories in Asia, Africa, Europe, and the Americas 1 . According to the World Health Organization (WHO), between December 2013, and 2017, the islands of the Caribbean and the Americas registered >2,5 million suspected and confirmed 3 .…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Genomic epidemiology of Chikungunya virus in Colombia reveals genetic variability of strains and multiple geographic introductions in outbreak, 2014

Villero-Wolf

Máttar

Puerta-González

et al. 2019

Sci Rep

View full text Add to dashboard Cite

Chikungunya virus (CHIKV) is considered a public health problem due to its rapid spread and high morbidity. This study aimed to determine the genetic diversity and phylogenetic relationships of CHIKVs in Colombia. A descriptive and retrospective study was carried out using sera of patients infected with Chikungunya during the outbreak in Colombia. The whole genomes of CHIKV (n = 16) were sequenced with an Illumina Hi-seq 2500 and were assembled using the Iterative Virus Assembler software. A Bayesian inference phylogenetic analysis was carried out with 157 strains of worldwide origin. The Colombian CHIKV sequences were grouped in the Asian genotype; however, three independent phylogenetic subclades were observed, probably the result of three separate introductions from Panama, Nicaragua, and St. Barts. Each subclade showed several different non-synonymous mutations (nsP2-A153V; nsp2-Y543H; nsp2-G720A; nsP3-L458P; Capside R78Q), that may have functional consequences for CHIKV biology and pathogenesis. These same mutations may affect the efficacy of potential CHIKV vaccines.

show abstract

The global emergence of Chikungunya infection: An integrated view

Manzoor

Javed²,

Ejaz

et al. 2021

Reviews in Medical Virology

View full text Add to dashboard Cite

Chikungunya virus (CHIKV) is one of the emerging viruses around the globe. It belongs to the family Togaviridae and genus Alphavirus and is an arthropod borne virus that transmits by the bite of an infected mosquito, mainly through Aedes aegypti and Aedes albopcitus. It is a spherical, enveloped virus with positive single stranded RNA genome. It was first discovered during 1952-53 in Tanganyika, after which outbreaks were documented in many regions of the world. CHIKV has two transmission cycles; an enzootic sylvatic cycle and an urban cycle. CHIKV genome contains 11,900 nucleotides and two open reading frames and shows great sequence variability. Molecular mechanisms of virus host-cell interactions and the pathogenesis of disease are not fully understood. The disease involves three phases; acute, post-acute and chronic with symptoms including high-grade fever, arthralgia, macupapular rashes and headache. There is no licensed vaccine or specific treatment for CHIKV infection. This lack of specific interventions combined with difficulties in making a precise diagnosis together make the disease difficult to manage.In this review we aim to present the current knowledge of global epidemiology, transmission, structure, various aspects of diagnosis as well as highlight potential antiviral drugs and vaccines against CHIKV.

show abstract

Recent progress on chikungunya virus research

Abstract: Chikungunya virus (CHIKV) is an arbovirus transmitted by

Cited by 19 publications

References 94 publications

Conducta práctica ante un niño febril al regresar de un viaje

Conducta práctica ante un niño febril al regresar de un viaje

Genomic epidemiology of Chikungunya virus in Colombia reveals genetic variability of strains and multiple geographic introductions in outbreak, 2014

The global emergence of Chikungunya infection: An integrated view

Contact Info

Product

Resources

About