Recent Progress on Graphene-based Electrochemical Biosensors

Shen, Jingjing; Li, Huihua; Wang, Linlin; Cao, Dashun; Feng, Xiqi; Liu, Yuge; Ma, Yanwen; Wang, Lianhui

doi:10.1002/tcr.201500236

Cited by 30 publications

(13 citation statements)

References 152 publications

(138 reference statements)

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“…Graphene and its derivatives are studied for the construction of novel biosensor interface [67], which is critical for interface-based biosensors including electrochemical biosensors, electrochemiluminescent (ECL) biosensors and FET biosensor [86]. Many recent studies reported that nanocomposites based on graphene showed improved capability of combining different biomolecules, with higher surface area [87] and excellent biocompatibility [88].…”

Section: Biosensor Interfaces Based On Graphenementioning

confidence: 99%

“…Many recent studies applied graphene-related materials as excellent carriers for the construction of novel nanocomposites for biosensor signal amplification [122–124]. These graphene-based composites were developed by combining graphene or its derivates with metal oxides, metal nanoparticles, or conductive polymers, etc., and this kind of composites showed unique catalytic/chemical activity [86], that has been widely applied in PC biosensors [125].…”

Section: Graphene-based Composites For Signal-amplificationmentioning

confidence: 99%

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Graphene-based biosensors for the detection of prostate cancer protein biomarkers: a review

Wen

Pandit

et al. 2019

BMC Chemistry

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Prostate cancer (PC) is the sixth most common cancer type in the world, which causes approximately 10% of total cancer fatalities. The detection of protein biomarkers in body fluids is the key topic for the diagnosis and prognosis of PC. Highly sensitive screening of PC is the most effective approach for reducing mortality. Thus, there are a growing number of literature that recognizes the importance of new technologies for early diagnosis of PC. Graphene is playing an important role in the biosensor field with remarkable physical, optical, electrochemical and magnetic properties. Many recent studies demonstrated the potential of graphene materials for sensitive detection of protein biomarkers. In this review, the graphene-based biosensors toward PC analysis are mainly discussed in two groups: Firstly, novel biosensor interfaces were constructed through the modification of graphene materials onto sensor surfaces. Secondly, ingenious signal amplification strategies were developed using graphene materials as catalysts or carriers. Graphene-based biosensors have exhibited remarkable performance with high sensitivities, wide detection ranges, and long-term stabilities.

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Section: Biosensor Interfaces Based On Graphenementioning

confidence: 99%

Section: Graphene-based Composites For Signal-amplificationmentioning

confidence: 99%

Graphene-based biosensors for the detection of prostate cancer protein biomarkers: a review

Wen

Pandit

et al. 2019

BMC Chemistry

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“…Graphene paper displayed outstanding physical and electrochemical properties, such as high conductivity, large surface area, abundant defect sites, superior electrocatalytic activity and fast electron transfer rate, hence various enzyme biosensors based on this attractive material have been fabricated recently [11,95]. We have successfully fabricated graphene paper doped with chemically compatible PBNPs as a nanohybrid electrocatalyst [36].…”

Section: Enzyme-graphene Paper Sensorsmentioning

confidence: 99%

“…In the past two decades, intensive research and development of electrochemical sensors have enabled to fabricate different types of devices. After the development of many successful commercial devices [7][8][9][10][11]. As outlined below, several crucial methods have been developed to assemble the layered structure of graphene papers.…”

Section: Introductionmentioning

confidence: 99%

Graphene-Paper Based Electrochemical Sensors

Zhang¹,

Halder²,

Cao³

et al. 2017

Electrochemical Sensors Technology

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Graphene paper as a new form of graphene-supported nanomaterials has received worldwide attention since its first report in 2007. Due to their high flexibility, lightweight and good electrical conductivity, graphene papers have demonstrated the promising potential for crucial applications in electrochemical sensors and energy technologies among others. In this chapter, we present some examples to overview recent advances in the research and development of two-dimensional (2D) graphene papers as new materials for electrochemical sensors. The chapter covers the design, fabrication, functionalization and application evaluations of graphene papers. We first summarize the mainstream methods for fabrication of graphene papers/membranes, with the focus on chemical vapour deposition techniques and solution-processing assembly approaches. A large portion of this chapter is then devoted to the highlights of specific functionalization of graphene papers with polymer and nanoscale functional building blocks for electrochemical-sensing purposes. In terms of electrochemical-sensing applications, the emphasis is on enzyme-graphene and nanoparticle-graphene paper-based systems for the detection of glucose. We finally conclude this chapter with brief remarks and outlook.

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“…The first glucose oxidase (GOx) electrode was developed in 1962. 1 Since then, a wide variety of electrode materials have been reported for glucose sensors including polymers, 2 sol-gel, 3 mesoporous silica, 4 metal nanoparticles, 5 carbon nanotubes 6 and graphene-based nanomaterials. 7,8 Glucose oxidase has been recognized as an enzyme for monitoring glucose.…”

mentioning

confidence: 99%

Functionalization of CVD Grown Graphene with Downstream Oxygen Plasma Treatment for Glucose Sensors

Hadish

Jou

Huang

et al. 2017

J. Electrochem. Soc.

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The development of graphene-based devices requires control over the functionalization and modification of the graphene surface. We studied the modification of the monolayer graphene surface with downstream oxygen plasma treatment to form graphene oxide (GO) for use in glucose biosensors. Amperometric and voltammetric methods were applied to GO for glucose oxidase (GOx) immobilization with a simultaneous reduction of GO to reduce graphene oxide. The fabricated glucose sensor shows a sensitivity of 0.118 μA mM −1 cm −2 and a detection limit of 0.0526 mM of glucose. This method provides fast and simultaneous immobilization of GOx and reduction of GO, and can be used in the fabrication of other electrochemical biosensors. Glucose oxidase has been recognized as an enzyme for monitoring glucose. In amperometric biosensors for glucose detection, GOx is immobilized on a nanomaterial surface and catalytically oxidizes glucose for high sensitivity and selectivity.9-11 However, enzyme immobilization is complicated by poor electrical communication of the active sites of the enzyme and the electrode surface, and by enzyme leaching. [12][13][14][15] Recently, graphene has been used to modify biosensors, offering advantages for enzyme immobilization on graphene surfaces. [16][17][18] Pristine graphene (PrG), a monolayer structure composed of one-atom thick two-dimensional honeycomb lattices of sp 2 carbon atoms, has extraordinary properties such as high intrinsic mobility and excellent thermal and electrical conductivity. [19][20][21][22] Although the bulk properties of graphene are very promising for a variety of applications, the development of graphene-based devices requires great control over the functionalization and modification of the graphene surface. Graphene oxide (GO) is one branch of functionalized graphene. GO is typically covalently functionalized with hydroxyl, epoxy, carbonyl, and carboxyl groups on its basal planes and at its edges, 23 resulting in a hybrid structure comprising a mixture of sp 2 and sp 3 hybridized carbon atoms. 24 GO sheets synthesized from graphite powders by the modified Hummers method 25 have been coated on carbon and Pt electrodes and used to immobilize GOx to develop glucose sensors. [26][27][28][29] On the other hand, monolayer graphene has been fabricated by chemical vapor deposition (CVD) on Cu and Ni substrates then transferred to other substrates for chemical and gas sensors. [30][31][32] Monolayer graphene has also been utilized for glucose sensor after immobilizing GOx to its surface through linker molecules. 33,34 With the aid of lithography and plasma etch techniques, monolayer-graphene-based devices can be patterned into arrays 32 and integrated with Si microelectronics technology. 35,36 In this work we synthesized GO from monolayer graphene by a downstream oxygen plasma. 37,38 The plasma-assisted technique has the advantages of short treatment time, an environmentally friendly manufacturing process, and the generation of numerous active species. 39 The immobilization of GOx en...

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Recent Progress on Graphene-based Electrochemical Biosensors

Cited by 30 publications

References 152 publications

Graphene-based biosensors for the detection of prostate cancer protein biomarkers: a review

Graphene-based biosensors for the detection of prostate cancer protein biomarkers: a review

Graphene-Paper Based Electrochemical Sensors

Functionalization of CVD Grown Graphene with Downstream Oxygen Plasma Treatment for Glucose Sensors

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