Recent progresses in marine microbial-derived antiviral natural products

Teng, Yun‐Fei; Xu, Li; Wei, Mei‐Yan; Wang, Chang‐Yun; Gu, Yu‐Cheng; Shao, Chang‐Lun

doi:10.1007/s12272-020-01286-3

Cited by 27 publications

(26 citation statements)

References 63 publications

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“…Marine microorganisms are well-known producers of antiviral agents. A total of 89 antiviral compounds representing eight structural classes have been isolated from marine microbes between 2015 and 2019 [ 63 ]. Several studies have reported that marine streptomycetes are excellent producers of antiviral compounds [ 64 – 69 ].…”

Section: Discussionmentioning

confidence: 99%

Isolation and characterization of marine sponge–associated Streptomyces sp. NMF6 strain producing secondary metabolite(s) possessing antimicrobial, antioxidant, anticancer, and antiviral activities

Fahmy

Abdel-Tawab

2021

Journal of Genetic Engineering and Biotechnology

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Background Actinomycetes associated with marine sponge represent a promising source of bioactive compounds. Herein, we report the isolation, identification, and bioactivity evaluation of Streptomyces sp. NMF6 associated with the marine sponge Diacarnus ardoukobae. Results Results showed that the strain belonged to the genus Streptomyces, and it was designated as Streptomyces sp. NMF6 with the GenBank accession number MW015111. Ethyl acetate (EtOAc) extract of the strain NMF6 demonstrated a promising antimicrobial activity against Staphylococcus aureus, Enterococcus faecalis, Vibrio damsela, and Candida albicans and a strong antioxidant activity, which were confirmed by DPPH, ferric-reducing power, and phosphomolybdenum assays; results are expressed as ascorbic acid equivalents. NMF6 extract also demonstrated cytotoxicity against breast cancer cell line (MCF-7), hepatocellular carcinoma cell line (Hep-G2), and human colon carcinoma cell line (HCT-116); the selectivity index values were < 2. The extract showed promising antiviral activity against HSV-1, CoxB4, and hepatitis A viruses at concentrations that were nontoxic to the host cells, with the selectivity index values being 13.25, 9.42, and 8.25, respectively. GC-MS analysis of the extract showed the presence of 20 compounds, with bis(2-ethylhexyl) phthalate being the major component (48%). Conclusions Our study indicates that the marine sponge–associated Streptomyces sp. NMF6 strain is a potential source of bioactive compounds that could be developed into therapeutic agents.

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Section: Discussionmentioning

confidence: 99%

Isolation and characterization of marine sponge–associated Streptomyces sp. NMF6 strain producing secondary metabolite(s) possessing antimicrobial, antioxidant, anticancer, and antiviral activities

Fahmy

Abdel-Tawab

2021

Journal of Genetic Engineering and Biotechnology

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“…gs 2021, 19, x 2 of 28 substances are usually unmatched by those derived from the terrestrial organisms. Thus far, scientists have isolated numerous natural products with antitumor, antibacterial, and other biological activities from marine organisms [12,[15][16][17][18][19].…”

Section: Methodologies Of Screening Marine Antimicrobial Substancesmentioning

confidence: 99%

“…The structures and pharmacological effects of these marine-derived active substances are usually unmatched by those derived from the terrestrial organisms. Thus far, scientists have isolated numerous natural products with antitumor, antibacterial, and other biological activities from marine organisms [ 12 , 15 , 16 , 17 , 18 , 19 ]. Modern pharmacological studies also demonstrate that many marine biological metabolites show good effects on killing phytopathogenic bacteria, which possibly can be used for developing biological fungicides [ 20 , 21 , 22 , 23 , 24 ].…”

Section: Introductionmentioning

confidence: 99%

Screening of Marine Bioactive Antimicrobial Compounds for Plant Pathogens

Zhao

Chen

2021

Marine Drugs

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Plant diseases have been threatening food production. Controlling plant pathogens has become an important strategy to ensure food security. Although chemical control is an effective disease control strategy, its application is limited by many problems, such as environmental impact and pathogen resistance. In order to overcome these problems, it is necessary to develop more chemical reagents with new functional mechanisms. Due to their special living environment, marine organisms have produced a variety of bioactive compounds with novel structures, which have the potential to develop new fungicides. In the past two decades, screening marine bioactive compounds to inhibit plant pathogens has been a hot topic. In this review, we summarize the screening methods of marine active substances from plant pathogens, the identification of marine active substances from different sources, and the structure and antibacterial mechanism of marine active natural products. Finally, the application prospect of marine bioactive substances in plant disease control was prospected.

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“…Furthermore, they can act as inducers of reactive oxygen species and bioreductive alkylators of biomolecules, and suppress DNA function by interpolation into DNA ( Roa-Linares et al, 2019 ). Quinones are used as antioxidant, antimicrobial, anticancer, anti-inflammatory, antitumor agents ( El-Najjar et al, 2011 ; Teng et al, 2020 ). The coccoquinone A, an anthraquinone derivative, obtained from Aspergillus versicolor function as an anti-HSV agent with the EC 50 value 6.25 µM ( Huang Z. et al, 2017 ).…”

Section: Microbial Metabolites As Potential Antiviral Candidatesmentioning

confidence: 99%

Microbial Metabolites: The Emerging Hotspot of Antiviral Compounds as Potential Candidates to Avert Viral Pandemic Alike COVID-19

Raihan

Rabbee

Roy

et al. 2021

Front. Mol. Biosci.

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The present global COVID-19 pandemic caused by the noble pleomorphic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has created a vulnerable situation in the global healthcare and economy. In this pandemic situation, researchers all around the world are trying their level best to find suitable therapeutics from various sources to combat against the SARS-CoV-2. To date, numerous bioactive compounds from different sources have been tested to control many viral diseases. However, microbial metabolites are advantageous for drug development over metabolites from other sources. We herein retrieved and reviewed literatures from PubMed, Scopus and Google relevant to antiviral microbial metabolites by searching with the keywords “antiviral microbial metabolites,” “microbial metabolite against virus,” “microorganism with antiviral activity,” “antiviral medicine from microbial metabolite,” “antiviral bacterial metabolites,” “antiviral fungal metabolites,” “antiviral metabolites from microscopic algae’ and so on. For the same purpose, the keywords “microbial metabolites against COVID-19 and SARS-CoV-2” and “plant metabolites against COVID-19 and SARS-CoV-2” were used. Only the full text literatures available in English and pertinent to the topic have been included and those which are not available as full text in English and pertinent to antiviral or anti-SARS-CoV-2 activity were excluded. In this review, we have accumulated microbial metabolites that can be used as antiviral agents against a broad range of viruses including SARS-CoV-2. Based on this concept, we have included 330 antiviral microbial metabolites so far available to date in the data bases and were previously isolated from fungi, bacteria and microalgae. The microbial source, chemical nature, targeted viruses, mechanism of actions and IC50/EC50 values of these metabolites are discussed although mechanisms of actions of many of them are not yet elucidated. Among these antiviral microbial metabolites, some compounds might be very potential against many other viruses including coronaviruses. However, these potential microbial metabolites need further research to be developed as effective antiviral drugs. This paper may provide the scientific community with the possible secret of microbial metabolites that could be an effective source of novel antiviral drugs to fight against many viruses including SARS-CoV-2 as well as the future viral pandemics.

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Recent progresses in marine microbial-derived antiviral natural products

Cited by 27 publications

References 63 publications

Isolation and characterization of marine sponge–associated Streptomyces sp. NMF6 strain producing secondary metabolite(s) possessing antimicrobial, antioxidant, anticancer, and antiviral activities

Isolation and characterization of marine sponge–associated Streptomyces sp. NMF6 strain producing secondary metabolite(s) possessing antimicrobial, antioxidant, anticancer, and antiviral activities

Screening of Marine Bioactive Antimicrobial Compounds for Plant Pathogens

Microbial Metabolites: The Emerging Hotspot of Antiviral Compounds as Potential Candidates to Avert Viral Pandemic Alike COVID-19

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