Recent progressions in biomedical and pharmaceutical applications of chitosan nanoparticles: A comprehensive review

Khalaf, Eman M.; Abood, Noor Adil; Atta, Raghad Z; Ramírez‐Coronel, Andrés Alexis; Alazragi, Reem; Romero-Parra, Rosario Mireya; Abed, Osama H; Abosaooda, Munther; Jalil, Abduladheem Turki; Mustafa, Yasser Fakri; Narmani, Asghar; Farhood, Bagher

doi:10.1016/j.ijbiomac.2023.123354

Cited by 83 publications

(12 citation statements)

References 242 publications

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“…Also, CS can bind with bacterial DNA to enter the nucleus of microorganisms, which inhibits mRNA synthesis and consequently protein synthesis [ 70 ]. The antimicrobial activity of chitosan is influenced by several intrinsic factors, including its origin (derived from crustaceans, insect shells, or fungi), concentration, MW, chain configuration, and DDA, as well as extrinsic factors such as environmental pH, and the specific type of microorganism and its susceptibility [ 50 , 71 ]. Concerning pulmonary pathologies, there are reports that CS-based nanoparticles are able to enhance antimicrobial activity against M. tuberculosis [ 72 ] and Pseudomonas aeruginosa [ 20 ], which is associated with lung infection in patients with cystic fibrosis.…”

Section: Chitosan: Physicochemical and Biological Propertiesmentioning

confidence: 99%

Advancements in Chitosan-Based Nanoparticles for Pulmonary Drug Delivery

Zacaron,

Silva,

Costa

et al. 2023

Polymers

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The evolution of respiratory diseases represents a considerable public health challenge, as they are among the leading causes of death worldwide. In this sense, in addition to the high prevalence of diseases such as asthma, chronic obstructive pulmonary disease, pneumonia, cystic fibrosis, and lung cancer, emerging respiratory diseases, particularly those caused by members of the coronavirus family, have contributed to a significant number of deaths on a global scale over the last two decades. Therefore, several studies have been conducted to optimize the efficacy of treatments against these diseases, focusing on pulmonary drug delivery using nanomedicine. Thus, the development of nanocarriers has emerged as a promising alternative to overcome the limitations of conventional therapy, by increasing drug bioavailability at the target site and reducing unwanted side effects. In this context, nanoparticles composed of chitosan (CS) show advantages over other nanocarriers because chitosan possesses intrinsic biological properties, such as anti-inflammatory, antimicrobial, and mucoadhesive capacity. Moreover, CS nanoparticles have the potential to enhance drug stability, prolong the duration of action, improve drug targeting, control drug release, optimize dissolution of poorly soluble drugs, and increase cell membrane permeability of hydrophobic drugs. These properties could optimize the performance of the drug after its pulmonary administration. Therefore, this review aims to discuss the potential of chitosan nanoparticles for pulmonary drug delivery, highlighting how their biological properties can improve the treatment of pulmonary diseases, including their synergistic action with the encapsulated drug.

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Section: Chitosan: Physicochemical and Biological Propertiesmentioning

confidence: 99%

Advancements in Chitosan-Based Nanoparticles for Pulmonary Drug Delivery

Zacaron,

Silva,

Costa

et al. 2023

Polymers

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“…Chitosan and its derivatives are used in the therapeutic treatment of a variety of disorders, showing promising benefits in cholesterol reduction, immunomodulation, hemostasis, and the management of diseases such as cancer and diabetes [ 56 ]. Furthermore, they are suitable in avoiding oral diseases, such as periodontitis, mouth ulcers, and dental caries [ 57 ].…”

Section: Biological Importance Of Chitosanmentioning

confidence: 99%

Optimized DOX Drug Deliveries via Chitosan-Mediated Nanoparticles and Stimuli Responses in Cancer Chemotherapy: A Review

Imran,

Tang,

Wang

et al. 2023

Molecules

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Chitosan nanoparticles (NPs) serve as useful multidrug delivery carriers in cancer chemotherapy. Chitosan has considerable potential in drug delivery systems (DDSs) for targeting tumor cells. Doxorubicin (DOX) has limited application due to its resistance and lack of specificity. Chitosan NPs have been used for DOX delivery because of their biocompatibility, biodegradability, drug encapsulation efficiency, and target specificity. In this review, various types of chitosan derivatives are discussed in DDSs to enhance the effectiveness of cancer treatments. Modified chitosan–DOX NP drug deliveries with other compounds also increase the penetration and efficiency of DOX against tumor cells. We also highlight the endogenous stimuli (pH, redox, enzyme) and exogenous stimuli (light, magnetic, ultrasound), and their positive effect on DOX drug delivery via chitosan NPs. Our study sheds light on the importance of chitosan NPs for DOX drug delivery in cancer treatment and may inspire the development of more effective approaches for cancer chemotherapy.

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“…Nano-medicine uses various nanotechnology tools to create quicker and more effective treatments for illnesses or disease management [ 22 ]. One of the materials employed the most frequently in nanotechnology is chitosan, a degradable polysaccharide with various applications [ 23 , 24 ]. Because nanostructured materials may amplify the action of plant extracts, decreasing the needed dose and adverse effects, and enhancing activity, employing the nanocapsule formulation has numerous benefits over using the herbal addition.…”

Section: Introductionmentioning

confidence: 99%

Chitosan neem nanocapsule enhances immunity and disease resistance in nile tilapia (Oreochromis niloticus)

Ibrahim,

Elshopakey,

Abdelwarith

et al. 2023

Heliyon

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Recent progressions in biomedical and pharmaceutical applications of chitosan nanoparticles: A comprehensive review

Cited by 83 publications

References 242 publications

Advancements in Chitosan-Based Nanoparticles for Pulmonary Drug Delivery

Advancements in Chitosan-Based Nanoparticles for Pulmonary Drug Delivery

Optimized DOX Drug Deliveries via Chitosan-Mediated Nanoparticles and Stimuli Responses in Cancer Chemotherapy: A Review

Chitosan neem nanocapsule enhances immunity and disease resistance in nile tilapia (Oreochromis niloticus)

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