Recent Studies of Man-Made Vitreous Fibers

Bunn, William B.; Bender, Joel; Hesterberg, Thomas W.; Chase, Gerald R.; Konzen, J L

doi:10.1097/00043764-199302000-00009

Cited by 81 publications

(32 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A high incidence of pleural mesotheliomas occurred in hamsters but not in rats exposed simultaneously by inhalation to a kaolin-based refractory ceramic fiber (RCF-1) (2). Similar interspecies differences in mesotheliomagenic potential between 229 0192-6233/94$3.00+$0.00 TOXICOLOGIC PATHOLOGY these 2 rodent species have been noted following intratracheal instillation of glass fiber (1 6).…”

Section: Introductionmentioning

confidence: 95%

See 1 more Smart Citation

Pleural Lesions in Syrian Golden Hamsters and Fischer-344 Rats Following Intrapleural Instillation of Man-made Ceramic or Glass Fibers

et al. 1994

View full text Add to dashboard Cite

AESTRACIThe mesothelium is a target of the toxic and carcinogenic effects of certain natural mineral and man-made fibers. Long-term inhalation of a ceramic fiber (RCF-1) results in a high incidence of pleural mesotheliomas in Syrian golden hamsters but not in identically exposed Fischer-344 rats. The present study compared the histopathology of the early pleural response in rats and hamsters instilled with artificial fibers. Groups of Syrian golden hamsters and Fischer-344 rats were instilled with ceramic (RCF-1) or glass (MMVF-10) fibers directly into the pleural space. Each species received approximately equal numbers of long, thin fibers per g body weight. Fiber-induced lesions were compared 7 and 28 days postinstillation. Both hamsters and rats developed qualitatively similar dose-dependent inflammatory lesions that were not fiber-type specific. Both species developed fibrosis in conjunction with inflammation in the visceral pleura, but a striking interspecies difference was noted in the pattern of mesothelial cell response. Hamsters developed greater surface mesothelial cell proliferation and had focal aggregates of mesothelial cells embedded deep within regions of visceral pleural fibrosis. It is hypothesized from the present study that the marked fiber-induced proliferative mesothelial cell response of the hamster visceral pleura may explain the high number of pleural mesotheliomas found in long-term fiber studies in this species.

show abstract

Section: Introductionmentioning

confidence: 95%

“…These tumors can be experimentally induced by inhalation or intracavitary instillation of certain fibrous particulates (2,3,7,8). Despite many disease similarities, there is controversy regarding the sensitivity of rodent bioassays for assessing the human carcinogenic risk posed by inhaled fibers.…”

Section: Introductionmentioning

confidence: 99%

Pleural Lesions in Syrian Golden Hamsters and Fischer-344 Rats Following Intrapleural Instillation of Man-made Ceramic or Glass Fibers

et al. 1994

View full text Add to dashboard Cite

show abstract

“…Considerable experimental data are now available concerning MMVF (41)(42)(43). They point out the importance of three major parameters that can contribute to chronic lung disease, namely, diameter, durability (or biopersistence), and dose.…”

Section: Health Implicationsmentioning

confidence: 99%

Ubiquitous fiber exposure in selected sampling sites in Europe

Schneider

Burdett²,

Martinon³

et al. 1996

Scand J Work Environ Health

View full text Add to dashboard Cite

“…The results of this study are discussed in terms of the pathogenicities of the fibers, known from published long-term animal studies (3,(11)(12)(13)(14).…”

Section: Introductionmentioning

confidence: 99%

“…There is concern that other industrial materials, such as refractory fibers, vitreous fibers, and insulation wools, which generate respirable airborne fibers may also be harmful. The relative potency of these fibers to cause lung disease in comparison with asbestos has been the subject of much research and continues to be controversial (3)(4)(5). Long-term animal inhalation studies probably provide the most reliable prediction of the hazards of a particular fiber type.…”

Section: Introductionmentioning

confidence: 99%

Short-term inhalation and in vitro tests as predictors of fiber pathogenicity.

Cullen

Miller

Davis

et al. 1997

Environ Health Perspect

View full text Add to dashboard Cite

A wide range of fiber types was tested in two in vitro assays: toxicity to A549 epithelial cells, as detachment from substrate, and the production of the proinflammatory cytokine tumor necrosis factor (TNF) by rat alveolar macrophages. Three of the fibers were also studied in vivo, using short-term inhalation followed by a) bronchoalveolar lavage to assess the inflammatory response and b) measurement of cell proliferation in terminal bronchioles and alveolar ducts, using incorporation of bromodeoxyuridine (BrdU). The amount of TNF produced by macrophages in vitro depended on the fiber type, with the man-made vitreous fibers, and refractory ceramic fibers being least stimulatory and silicon carbide (SiC) whiskers providing the greatest stimulation. In the epithelial detachment assay there were dose-dependent differences in the toxicity of the various fibers, with long amosite being the most toxic. However, there was no clear relationship to known chronic pathogenicity. Fibers studied by short-term inhalation produced some inflammation, but there was no clear discrimination between the responses to code 100/475 glass fibers and the more pathogenic amosite and SiC. However, measurements of BrdU uptake into lung cells showed that amosite and SiC produced a greater reaction than code 100/475, which itself caused no more proliferation than that seen in untreated lungs. These results mirror the pathogenicity ranking of the fibers in long-term experiments. In conclusion, the only test to show potential as a predictive measure of pathogenicity was that of cell proliferation in lungs after brief inhalation exposure (BrdU assay). We believe that this assay should be validated with a wider range of fibers, doses, and time points. Environ Health Perspect 1 05(Suppl 5):1 235-1 240 (1997)

show abstract

Recent Studies of Man-Made Vitreous Fibers

Cited by 81 publications

References 5 publications

Pleural Lesions in Syrian Golden Hamsters and Fischer-344 Rats Following Intrapleural Instillation of Man-made Ceramic or Glass Fibers

Pleural Lesions in Syrian Golden Hamsters and Fischer-344 Rats Following Intrapleural Instillation of Man-made Ceramic or Glass Fibers

Ubiquitous fiber exposure in selected sampling sites in Europe

Short-term inhalation and in vitro tests as predictors of fiber pathogenicity.

Contact Info

Product

Resources

About