Recent studies on terpenoids in Aspergillus fungi: Chemical diversity, biosynthesis, and bioactivity

Zhao, Wen‐Yu; Jin, Yi; Chang, Yi-Bo; Sun, Cheng‐Peng; Ma, Xiaochi

doi:10.1016/j.phytochem.2021.113011

Cited by 25 publications

(9 citation statements)

References 121 publications

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“…To further showcase the possibilities, two additional queries were established ( https://w.wiki/4VGC and https://w.wiki/4VGD ). Both queries were inspired by recent literature review works ( Jose et al, 2021 ; Zhao et al, 2022 ). The first work describes compounds found in Actinobacteria, with a biological focus on compounds with reported bioactivity.…”

Section: Resultsmentioning

confidence: 99%

The LOTUS initiative for open knowledge management in natural products research

Rutz

Sorokina

Galgonek

et al. 2022

eLife

173

121

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Contemporary bioinformatic and chemoinformatic capabilities hold promise to reshape knowledge management, analysis and interpretation of data in natural products research. Currently, reliance on a disparate set of non-standardized, insular, and specialized databases presents a series of challenges for data access, both within the discipline and for integration and interoperability between related fields. The fundamental elements of exchange are referenced structure-organism pairs that establish relationships between distinct molecular structures and the living organisms from which they were identified. Consolidating and sharing such information via an open platform has strong transformative potential for natural products research and beyond. This is the ultimate goal of the newly established LOTUS initiative, which has now completed the first steps toward the harmonization, curation, validation and open dissemination of 750,000+ referenced structure-organism pairs. LOTUS data is hosted on Wikidata and regularly mirrored on https://lotus.naturalproducts.net. Data sharing within the Wikidata framework broadens data access and interoperability, opening new possibilities for community curation and evolving publication models. Furthermore, embedding LOTUS data into the vast Wikidata knowledge graph will facilitate new biological and chemical insights. The LOTUS initiative represents an important advancement in the design and deployment of a comprehensive and collaborative natural products knowledge base.

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Section: Resultsmentioning

confidence: 99%

The LOTUS initiative for open knowledge management in natural products research

Rutz

Sorokina

Galgonek

et al. 2022

eLife

173

121

View full text Add to dashboard Cite

show abstract

“…To further showcase the possibilities, two additional queries were established (https://w.wiki/4VGC and https://w.wiki/4VGD). Both queries were inspired by recent literature review works [39, 40]. The first work describes compounds found in Actinobacteria, with a biological focus on compounds with reported bioactivity.…”

Section: Resultsmentioning

confidence: 99%

The LOTUS Initiative for Open Natural Products Research: Knowledge Management through Wikidata

Rutz

Sorokina

Galgonek

et al. 2021

Preprint

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As contemporary bioinformatic and chemoinformatic capabilities are reshaping natural products research, major benefits could result from an open database of referenced structure-organism pairs. Those pairs allow the identification of distinct molecular structures found as components of heterogeneous chemical matrices originating from living organisms. Current databases with such information suffer from paywall restrictions, limited taxonomic scope, poorly standardized fields, and lack of interoperability. To ensure data quality, references to the work that describes the structure-organism relationship are mandatory. To fill this void, we collected and curated a set of structure-organism pairs from publicly available natural products databases to yield LOTUS (naturaL prOducTs occUrrences databaSe), which contains over 500,000 curated and referenced structure-organism pairs. All the programs developed for data collection, curation, and dissemination are publicly available. To provide unlimited access as well as standardized linking to other resources, LOTUS data is both hosted on Wikidata and regularly mirrored on https://lotus.naturalproducts.net. The diffusion of these referenced structure-organism pairs within the Wikidata framework addresses many of the limitations of currently-available databases and facilitates linkage to existing biological and chemical data resources. This resource represents an important advancement in the design and deployment of a comprehensive and collaborative natural products knowledge base.Graphical abstractFigure 1:Graphical abstract

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“…Sesquiterpenoids are the largest group of known terpenoids [ 72 ]. The mangrove fungi-derived sesquiterpenoids possess a variety of carbon skeletons, including monocyclic, bicyclic, and tricyclic types [ 73 ].…”

Section: Unusual Natural Products From Mangrove-associated Microorgan...mentioning

confidence: 99%

Unusual Secondary Metabolites from the Mangrove Ecosystems: Structures, Bioactivities, Chemical, and Bio-Syntheses

Guo

2022

Marine Drugs

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Mangrove ecosystems are widely distributed in the intertidal zone of tropical and subtropical estuaries or coasts, containing abundant biological communities, for example, mangrove plants and diverse groups of microorganisms, featuring various bioactive secondary metabolites. We surveyed the literature from 2010 to 2022, resulting in a collection of 134 secondary metabolites, and classified them into two major families in terms of the biological sources and 15 subfamilies according to the chemical structures. To highlight the structural diversity and bioactivities of the mangrove ecosystem-associated secondary metabolites, we presented the chemical structures, bioactivities, biosynthesis, and chemical syntheses.

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Recent studies on terpenoids in Aspergillus fungi: Chemical diversity, biosynthesis, and bioactivity

Cited by 25 publications

References 121 publications

The LOTUS initiative for open knowledge management in natural products research

The LOTUS initiative for open knowledge management in natural products research

The LOTUS Initiative for Open Natural Products Research: Knowledge Management through Wikidata

Unusual Secondary Metabolites from the Mangrove Ecosystems: Structures, Bioactivities, Chemical, and Bio-Syntheses

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