Recent Synthetic and Biological Developments on 1,2,4‐Triazolopyrimidines

Abstract

Abstract1,2,4‐Triazolopyrimidines scaffold spaciously acknowledged with anticancer, antimalarial, antitubercular and many other fascinating biological applications in recent years (2015–2022). Moreover, numerous mild synthetic methodologies reported, which has been summarized as (i) condensation of 2‐amino‐1,2,4‐triazole or 5‐amino‐1,2,4‐triazole with 1,3‐dielectrophilic equivalents like 1,3‐diketones, β‐ketoester (ii) oxidative‐cyclization of hydrazones or related analogues. This review would flourish the synthetic and medicinal chemist to design more bioactive 1,2,4‐triazolopyrimidines molecules for drug development with enhanced binding interactions, structural features with the help discussed SAR and cost effective methodologies in the coming years.