Recent Trends in Economic Burden of Acute Myocardial Infarction in South Korea

Seo, Hye‐Young; Yoon, Seok Jun; Yoon, Ji-Hyun; Kim, Dongwoo; Gong, Young-Hoon; Kim, A. Rim; Oh, In Hwan; Kim, Eun Jung; Lee, Yo Han

doi:10.1371/journal.pone.0117446

Cited by 31 publications

(24 citation statements)

References 20 publications

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“…Those aged < 50 years accounted for 15.3% of the AMI cases. This observation is significant because this signals a possible loss of many years of productive life [ 39 ] in addition to the social [ 40 ], psychological [ 41 ] and physical trauma the patients and their close relatives and dependents experience [ 42 ], as well as the economic burden imposed [ 43 ].…”

Section: Discussionmentioning

confidence: 99%

Risk factors for first-time acute myocardial infarction patients in Trinidad

2018

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BackgroundThe relative importance of coronary artery disease (CAD) risk varies globally. The aim of this study was to determine CAD risk factors for acute myocardial infarction (AMI) among patients in public health care institutions in Trinidad using a case–control type study design.MethodsThe sample comprised 251 AMI patients hospitalized between March 1, 2011 and April 30, 2012 and 464 age- and sex-matched non-AMI patients with no terminal or life-threatening illness and who did not undergo treatment for CAD. SPSS version 19 was used for data analysis that included chi-square tests, unadjusted and adjusted odds ratios (OR) and conditional multiple binary logistic regression.ResultsThere was no difference in age between AMI and non-AMI patients (p = 0.551). Chi-square test revealed that clinical and lifestyle variables including stressful life, diabetes, hypertension, hypercholesterolaemia, ischaemic heart disease (IHD), a family history of IHD (p ≤ 0.001), smoking (p = 0.007) and alcohol consumption (p = 0.013) were associated with AMI; sex (p = 0.441), ethnicity (p = 0.366), age group (p = 0.826) and renal failure (p = 0.487) were not.Both unadjusted and adjusted (for age) ORs showed that the odds of hypertension, IHD and alcohol consumption were greater among AMI patients than among non-AMI patients for males; diabetes and IHD for females; and that the odds of a stressful life was greater among non-AMI patients and were the same for both groups with respect to sex, age > 45 years, hypercholesterolemia, renal insufficiency, and family history of IHD.Conditional multiple logistic regression showed that smoking [OR: 0.274, p ≤ 0.001, 95% CI for OR (0.140, 0.537)], a stressful life [OR: 2.697, p ≤ 0.001, 95% CI for OR (1.585, 4.587)], diabetes [OR: 0.530, p = 0.020, 95% CI for OR (0.310, 0.905)], hypertension [OR: 0.48, p = 0.10. 95% CI for OR (0.275, 0.837)] and IHD [OR: 0.111, p ≤ 0.001, 95% CI for OR (0.057, 0.218)] were the only useful AMI predictors.ConclusionsSmoking, diabetes, hypertension, IHD and decrease stress are useful AMI predictors.

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Section: Discussionmentioning

confidence: 99%

Risk factors for first-time acute myocardial infarction patients in Trinidad

2018

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“…The annual insurance-covered medical cost of osteoporotic fracture in our study ($722 million in 2011) was higher than the direct medical costs for acute myocardial infarction ($607 million in 2012). [ 26 ] On the basis of these results, the relative scale of osteoporotic fracture costs can be predicted, which highlights the need for prevention and management strategies for osteoporotic fractures. By comparing the estimated economic burden of multiple diseases, government officials can make informed decisions about the allocation of resources to service provision, prevention strategies, and research funding.…”

Section: Discussionmentioning

confidence: 99%

Healthcare Costs of Osteoporotic Fracture in Korea: Information from the National Health Insurance Claims Database, 2008-2011

Kim

et al. 2017

J Bone Metab

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BackgroundThe present study estimated healthcare costs of osteoporotic fractures including spine, hip, distal radius and humerus in Koreans over 50 years of age using national claims data.MethodsKorea National Health Insurance data between 2008 and 2011 was searched for all claims records of outpatient visits or hospital admissions of patients ≥50-year-of-age. Osteoporosis-related fractures were identified using certain the International Classification of Diseases, Tenth Revision codes and site-specific physician claims for procedures in a patient age cut-off value of 50 years. The healthcare costs included acute phase costs accounting for emergency medical care given immediately after fracture, costs due to further hospitalization and surgical procedures, physiotherapy sessions according to the site of the fracture, and outpatient visits in the year after discharge.ResultsThe total estimated healthcare costs of osteoporotic fractures in 2011 was $722 million. From 2008 to 2011, the total number and healthcare costs of osteoporotic fractures increased 28.9% (from 127,070 to 163,823) and 31.6% (from $549 million to $722 million), respectively. The portion of national health care expenditure was ranged from 2.3% in 2008 to 2.2% in 2011. The mean healthcare cost of osteoporotic fractures per person increased 2.1% from $4,321 in 2008 to $4,410 in 2011.The mean healthcare costs were highest for hip fractures followed by spine, humerus, and distal radius fractures.ConclusionsTotal Healthcare costs of osteoporotic fractures in South Koreans ≥50-year-of-age increased between 2008 and 2011. This trend will likely continue, which is an important health problem in the elderly population and economically.

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“…The prevalence of MI is increasing with the aging global population, leading to serious disease burdens [2, 3]. Reperfusion therapy, such as immediately percutaneous coronary intervention (PCI), has been used frequently in clinical practice and has been remarkably successful in increasing the rate of revascularization and reducing the mortality of MI patients [4].…”

Section: Introductionmentioning

confidence: 99%

Effect of Wenxin Granules on Gap Junction and MiR-1 in Rats with Myocardial Infarction

Zhao

Lou

et al. 2017

BioMed Research International

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Myocardial infarction (MI) patients are at high risk of potential lethal arrhythmia. Gap junction and microRNA-1 (miR-1) are both arrhythmia generating conditions. The present study investigated whether Wenxin Granules (Wenxin-Keli, WXKL) could prevent potential lethal arrhythmia by improving gap junctions and miR-1 following MI. Male Sprague-Dawley rats were divided randomly into control, model, metoprolol, low dose WXKL, and high dose WXKL groups. The MI rat model was created by coronary artery ligation. Treatments were administrated intragastrically to the rats for 4 weeks. Conventional transmission electron microscopy was performed to observe the ultrastructure of gap junctions. Quantitative real-time PCR and western blotting were used to detect the expression of miR-1, protein kinase C (PKC), and related proteins. Additionally, a programmatic electrophysiological stimulation test was performed to detect the ventricular fibrillation threshold (VFT). WXKL protected the ultrastructure of the gap junctions and their constituent Cx43 by regulating miR-1 and PKC mediated signal transduction and increased the VFT significantly in the rat MI model. The results suggested that WXKL is an effective alternative medicine to prevent potentially lethal arrhythmia following MI.

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Recent Trends in Economic Burden of Acute Myocardial Infarction in South Korea

Cited by 31 publications

References 20 publications

Risk factors for first-time acute myocardial infarction patients in Trinidad

Risk factors for first-time acute myocardial infarction patients in Trinidad

Healthcare Costs of Osteoporotic Fracture in Korea: Information from the National Health Insurance Claims Database, 2008-2011

Effect of Wenxin Granules on Gap Junction and MiR-1 in Rats with Myocardial Infarction

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