Recent trends in phytochemistry, ethnobotany and pharmacological significance of Alchornea cordifolia (Schumach. &amp; Thonn.) Muell. Arg.

Boniface, Pone Kamdem; Ferreira, Sabrina Baptista; Kaiser, Carlos R.

doi:10.1016/j.jep.2016.06.021

Cited by 36 publications

(19 citation statements)

References 72 publications

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“…The extracts of Alchornea cordifolia are those containing all ten groups of secondary metabolites sought. This result is the same as those obtained by a large number of studies where Alchornea cordifolia, thanks to its wide range of active ingredients, would be used as a panacea in several African countries and for the treatment of diseases of different orders [41,35]. In contrast to this study, saponins and alkaloids are absent in the aqueous extract of Alchornea cordifolia [34].…”

Section: Discussionsupporting

confidence: 89%

“…Furthermore, the reductive capacity of the aqueous extract (2.64±0.11 μg/ml) composed in same proportions of the aqueous extracts of Alchornea cordifolia and Antrocaryon klaineanum was greater than that of the hydroethanolic extract (2.86±0.0655 μg/ml) composed in 50: 50 proportions of hydroethanolic extracts of Alchornea cordifolia and Antrocaryon klaineanum. An ethnobotanical, phytochemical and pharmacological review of Alchornea cordifolia has also highlighted its antioxidant properties both in vitro and in vivo [35], reinforcing its therapeutic antiinfective potential. Agbor et al [33] Report that the extracts of this plant have a high antioxidant activity because of their ability to reduce iron and to trap free radicals.…”

Section: Discussionmentioning

confidence: 95%

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In Vitro Antioxidant and Anti-Inflammatory Activities of Alchornea Cordifolia (Schumach and Thonn.) Mull. Arg. And Antrocaryon Klaineanum Pierre Extracts

Ndjib

Djova

Kom

et al. 2020

Int J Pharm Pharm Sci

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Objective: This study aims to evaluate the in vitro antioxidant, anti-inflammatory activities of the aqueous and hydroethanolic extracts recipe of Alchornea cordifolia and Antrocaryon klaineanum. A preliminary phytochemical screening was carried out. Methods: The total phenols content was determined by the Folin Ciocalteu reagent method, while the antioxidant activity of both extracts was characterized by the 2-2diphenyl-1-picrilhidrazil (DPPH) and β-carotene assays. The anti-inflammatory activity of the extracts was evaluated as the inhibition of Bovine Serum Albumin (BSA) denaturation and antiproteinase activity. Results: The aqueous extracts of Alchornea cordifolia and Antrocaryon klaineanum contained more polyphenols [270 mg Ascorbic acid equivalent (AAE)/g dry weight (dw)] than the hydroethanolic recipe extract (262.41 mg AAE/g dw) at the same concentration level. On the other hand, the aqueous and hydroethanolic recipe extract had the same radical scavenging activity with the antiradical power of 0.851 and 0.830, respectively. Similarly, the recipe extract had the same reducing activity with reducing the power of 94.2±2.03 mg EAA/g dw and 97.4±4.16 mg EAA/g dw for the aqueous and hydroethanolic recipe extract of Alchornea cordifolia and Antrocaryon klaineanum respectively. For the anti-inflammatory activity it was observed that both extracts possess the same activity as Diclofenac® with an IC50 of 50.21 μg/ml. The phytochemical screening of the extracts revealed the presence of alkaloids, flavonoids, carbohydrates, phenols and tannins, which may account for their activities. Conclusion: The plant recipe extract studied possess antioxidant and anti-inflammatory potentials, which may be beneficiary to its consumers.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 95%

In Vitro Antioxidant and Anti-Inflammatory Activities of Alchornea Cordifolia (Schumach and Thonn.) Mull. Arg. And Antrocaryon Klaineanum Pierre Extracts

Ndjib

Djova

Kom

et al. 2020

Int J Pharm Pharm Sci

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show abstract

“…Plants are sources of active molecules with potential antimicrobial activity [ 31 , 32 ]. GA is a phenolic molecule compound found in many plant species with antimicrobial activity [ 12 , 33 , 34 ]. In the present study, GA presented MIC values of 0.625 and 1.25 mg/mL for C .…”

Section: Resultsmentioning

confidence: 99%

Gallic acid/hydroxypropyl-β-cyclodextrin complex: Improving solubility for application on in vitro/ in vivo Candida albicans biofilms

et al. 2017

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The aim of this study was to increase the solubility of gallic acid (GA) for the treatment of Candida albicans biofilm, which is very difficult to treat and requires high drug concentrations. Cyclodextrins (CDs) were used for this purpose. Complexes were evaluated by phase-solubility studies, prepared by spray drying and characterized by drug loading, scanning electron microscopy (SEM) and differential scanning calorimetry (DSC). The complexes were tested on C. albicans biofilm using in vitro and in vivo models. HPβCD formed soluble inclusion complexes with GA. The percentage of GA in GA/HPβCD was 10.8 ± 0.01%. The SEM and DSC analyses confirmed the formation of inclusion complexes. GA/HPβCD maintained the antimicrobial activity of the pure GA. GA/HPβCD was effective on C. albicans biofilms of 24 and 48h. The in vivo results showed an anti-inflammatory activity of GA/HPβCD with no difference in invading hypha counting among the groups. This study encourages the development of new antifungal agents.

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“…Though, the aqueouse extract gave higher yield than ethanol extract of the leaf of A. cordifolia, they are both very potent. A number of constituents responsible for the observed activities of A. cordifolia have also been mentioned in the literature review 18,24 reported that the parts of the plant mostly used for medicine are the leaves and stem bark but the leaves exhibit more potency. However, no comprehensive study has been carried out to confirm this.…”

Section: Discussionmentioning

confidence: 99%

Comparative Antimicrobial Activities of Alchornea cordifolia Leaf Crude Extracts and Cephalosporin Antibiotics on Some Pathogenic Clinical Isolates

Agboke

Nwosu

Obindo

et al. 2020

J. Drug Delivery Ther.

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Comparative antimicrobial activities of the aqueous and ethanol leaf extracts of Alchornea cordifolia and some Cephalosporin antibiotics of different generations available in Uy, LGA of Akwa Ibom state of Nigeria were evaluated using macro dilution assay to determine the Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC) of the plant aqueouse and ethanol leaf extracts and of the Cephalosporin antibiotics against some pathogenic Gram positive and Gram negative organisms. Results: The extraction yielded 59.9g for aqueouse leaf extract (ALE) and 74.10 g of the ethanol leaf extract. The MIC of the leaf extracts ranging from (1.953 mg/mL - 15.625 mg/ mL) and MBC ranging from (3.906 mg/mL – 62.50 mg/mL). The cephalosporin antibiotics; Ceftriaxone (Chupet®) MIC ranging from (0.0078-0.25 mg/mL), MBC (0.0312 mg/mL – 0.25 mg/mL), Cephalexin (Sporidex®) MIC ranging from (0.009766 mg/ mL - 0.625 mg/ mL), MBC (0.01953 mg/ mL -2.50 mg/ mL) and Cefuroxime with MIC ranging from (0.0078 mg/mL-0.25 mg/mL) and MBC (1.25 mg/mL - 2.5 mg/mL). Antimicrobial substances are considered as bactericidal agent when the ratio MBC/MIC ≤ 4 and bacteriostatic when the ratio MBC/MIC is > 4. The antimicrobial activities evaluated increased in the following order of potency; A. cordifolia leaf extracts > Ceftriaxone > Cefalexin > Cefuroxime considering the values of MBC/MIC. Keywords: Antimicrobial activities, bacteriostatic, bactericidal, cephalosporin, comparative.

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Recent trends in phytochemistry, ethnobotany and pharmacological significance of Alchornea cordifolia (Schumach. & Thonn.) Muell. Arg.

Cited by 36 publications

References 72 publications

In Vitro Antioxidant and Anti-Inflammatory Activities of Alchornea Cordifolia (Schumach and Thonn.) Mull. Arg. And Antrocaryon Klaineanum Pierre Extracts

In Vitro Antioxidant and Anti-Inflammatory Activities of Alchornea Cordifolia (Schumach and Thonn.) Mull. Arg. And Antrocaryon Klaineanum Pierre Extracts

Gallic acid/hydroxypropyl-β-cyclodextrin complex: Improving solubility for application on in vitro/ in vivo Candida albicans biofilms

Comparative Antimicrobial Activities of Alchornea cordifolia Leaf Crude Extracts and Cephalosporin Antibiotics on Some Pathogenic Clinical Isolates

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