Recent update on electrospinning and electrospun nanofibers: current trends and their applications

Nadaf, Arif; Gupta, Akash; Hasan, Nazeer; Fauziya,; Ahmad, Shadaan; Kesharwani, Prashant; Ahmad, Farhan Jalees

doi:10.1039/d2ra02864f

Cited by 126 publications

(42 citation statements)

References 131 publications

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“…Synthetic polymer-based spinning membranes, including polycaprolactone (PCL), poly(lactic-co-glycolic acid) (PLGA), and polyethylene glycol (PEG), are thin, exible, and biocompatible [46] . These membranes can be readily produced using a range of spinning techniques, including electrospinning, solution spinning, and melt spinning [47] . In our study, the PLLA/HA@Irisin nano bers demonstrated exceptional mechanical characteristics, including elevated tensile strength and exibility, rendering it an optimal candidate for bone tissue engineering.…”

Section: Discussionmentioning

confidence: 99%

Irisin-loaded electrospun core-shell nanofibers as calvarial periosteum accelerate vascularized bone regeneration by activating the mitochondrial SIRT3 pathway

Hua

Hou

Deng

et al. 2023

Preprint

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The scarcity of native periosteum poses a significant clinical barrier in the repair of critical-sized bone defects. The challenge of enhancing regenerative potential in bone healing is further compounded by oxidative stress at the fracture site. However, the introduction of artificial periosteum has demonstrated its ability to promote bone regeneration through the provision of appropriate mechanical support and controlled release of pro-osteogenic factors. In this study, a polylactic acid (PLLA)/hyaluronic acid (HA)-based nanofibrous membrane was fabricated using the coaxial electrospinning technique. The incorporation of irisin into the core-shell structure of PLLA/HA nanofibers (PLLA/HA@Irisin) achieved its sustained release. In vitro experiments demonstrated that the PLLA/HA@Irisin membranes exhibited favorable biocompatibility. The osteogenic differentiation of bone marrow mesenchymal stem cells (BMMSCs) was improved by PLLA/HA@Irisin, as evidenced by a significant increase in alkaline phosphatase (ALP) activity and matrix mineralization. Mechanistically, PLLA/HA@Irisin significantly enhanced the mitochondrial function of BMMSCs via the activation of the sirtuin 3 antioxidant pathway. To assess the therapeutic effectiveness, PLLA/HA@Irisin membranes were implanted in situ into critical-sized calvarial defects in rats. The results at four and eight weeks post-surgery indicated that the implantation of PLLA/HA@Irisin exhibited superior efficacy in promoting vascularized bone formation, as demonstrated by the enhancement of bone matrix synthesis and the development of new blood vessels. The results of our study indicate that the electrospun PLLA/HA@Irisin nanofibers possess characteristics of a biomimetic periosteum, showing potential for effectively treating critical-sized bone defects by improving the mitochondrial function and maintaining redox homeostasis of BMMSCs.

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Section: Discussionmentioning

confidence: 99%

Irisin-loaded electrospun core-shell nanofibers as calvarial periosteum accelerate vascularized bone regeneration by activating the mitochondrial SIRT3 pathway

Hua

Hou

Deng

et al. 2023

Preprint

View full text Add to dashboard Cite

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“…In this method, the biomaterial under construction into nanofibers (e.g., polymers) is synthesized inside the holes of a template membrane with uniformly sized orifices. This technique allows the synthesis of nanofibers with varying diameters, and this is usually achieved by changing the template settings [ 88 ]. The fabrication of nanofibrous scaffolds for skin tissue engineering using a template-assisted electrospinning technique was employed in the production of structural scaffolds with the use of polycaprolactone.…”

Section: Commonly Employed Manufacturing Techniquesmentioning

confidence: 99%

Nanofibrous Scaffolds for Diabetic Wound Healing

Aliyu

Adeleke

2023

Pharmaceutics

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Chronic wounds are one of the secondary health complications that develop in individuals who have poorly managed diabetes mellitus. This is often associated with delays in the wound healing process, resulting from long-term uncontrolled blood glucose levels. As such, an appropriate therapeutic approach would be maintaining blood glucose concentration within normal ranges, but this can be quite challenging to achieve. Consequently, diabetic ulcers usually require special medical care to prevent complications such as sepsis, amputation, and deformities, which often develop in these patients. Although several conventional wound dressings, such as hydrogels, gauze, films, and foams, are employed in the treatment of such chronic wounds, nanofibrous scaffolds have gained the attention of researchers because of their flexibility, ability to load a variety of bioactive compounds as single entities or combinations, and large surface area to volume ratio, which provides a biomimetic environment for cell proliferation relative to conventional dressings. Here, we present the current trends on the versatility of nanofibrous scaffolds as novel platforms for the incorporation of bioactive agents suitable for the enhancement of diabetic wound healing.

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“…Under the influence of external electrostatic fields, electrospinning technology, a sophisticated technique for fiber production, rapidly stretches polymers into continuous fibers with sizes varying from microns to nanometers [ 1 , 2 , 3 ]. Electrospinning technology has several advantages over other fiber film production techniques, including ease of operation, controllable process, high operability, low cost, and flexibility.…”

Section: Introductionmentioning

confidence: 99%

Recent Progress of the Preparation and Application of Electrospun Porous Nanofibers

Wang

Cao

et al. 2023

Polymers

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Electrospun porous nanofibers have gained a lot of interest recently in various fields because of their adjustable porous structure, high specific surface area, and large number of active sites, which can further enhance the performance of materials. This paper provides an overview of the common polymers, preparation, and applications of electrospun porous nanofibers. Firstly, the polymers commonly used to construct porous structures and the main pore-forming methods in porous nanofibers by electrospinning, namely the template method and phase separation method, are introduced. Secondly, recent applications of electrospun porous nanofibers in air purification, water treatment, energy storage, biomedicine, food packaging, sensor, sound and wave absorption, flame retardant, and heat insulation are reviewed. Finally, the challenges and possible research directions for the future study of electrospun porous nanofibers are discussed.

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Recent update on electrospinning and electrospun nanofibers: current trends and their applications

Abstract: Electrospinning is a versatile and viable technique for generating ultrathin fibers.

Cited by 126 publications

References 131 publications

Irisin-loaded electrospun core-shell nanofibers as calvarial periosteum accelerate vascularized bone regeneration by activating the mitochondrial SIRT3 pathway

Irisin-loaded electrospun core-shell nanofibers as calvarial periosteum accelerate vascularized bone regeneration by activating the mitochondrial SIRT3 pathway

Nanofibrous Scaffolds for Diabetic Wound Healing

Recent Progress of the Preparation and Application of Electrospun Porous Nanofibers

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