Recent Update on Proniosomal Gel as Topical Drug Delivery System

Abstract

An existence of transdermal delivery tool, proniosomal gel, has established to showed remarkable development for lipophilic/hydrophilic drugs over additional formulations. Newer drugs of lipophilic nature emerge poor bioavailability, irregular absorption, and pharmacokinetic changes. Therefore, this novel drug delivery system has been proved advantageous over other oral and topical delivery of drug candidates to bypass such disruption. This proniosomal gel basically is a compact semi-solid liquid crystalline (gel) composed of non-ionic surfactants easily formed on dissolving the surfactant in a minimal amount of acceptable solvent and the least amount of aqueous phase and phosphate buffer. Topical application of gel under occlusive condition during which they are converted into nisomes due to hydration by water in the skin present itself. Proniosomal gels are typically present in transparent, translucent, or white semisolid gel texture, which makes them physically stable throughout storage and transport. This review provides an important overview of the preparation, formulation, evaluation, and application of proniosome gel as a drug delivery carrier.

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“…Cholesterol is also known to prevent leakage by abolishing gel to liquid phase transition 21 . It prevents accumulation by the inclusion of molecules that stabilize the system against the formation of an aggregate by repulsive steric or electrostatic effects 22 .…”

Thin-layer hydration method to prepare a green tea extract niosomal gel and its antioxidant performance

“…Topical gels have the advantage of being easily applied, distributing evenly to the skin, easily drying, giving a cold feeling to the skin and forming a layer that is easily washed away as needed (Rathod & Mehta, 2015). Furthermore, the physiochemical properties of niosomes are maintained (Rajkumar et al, 2019). Also, because of their high water content and swelling processes, they can offer a better feeling for the skin.…”