Recent Updates on the Antimicrobial Compounds from Marine‐Derived <i>Penicillium</i> fungi

Li, Honghua; Fu, Yanqi; Song, Fuhang; Xu, Xiuli

doi:10.1002/cbdv.202301278

Cited by 3 publications

(1 citation statement)

References 90 publications

(157 reference statements)

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“…The Penicillium genus has the potential to produce a large quantity of secondary metabolites with appealing bioactivities, such as cytotoxic [1], antimicrobial [2] and antileukemia [3] activities. Penicillin, a well-known broad-spectrum antibiotic, was isolated from the genus Penicillium, inspiring researchers to investigate other potent natural products from this genus of fungi.…”

Section: Introductionmentioning

confidence: 99%

Penicillium janthinellum: A Potential Producer of Natural Products

Wang,

Li,

Wang

et al. 2024

Fermentation

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Penicillium is a kind of common filamentous fungi yielding high levels of secondary metabolites with diverse structures and attractive activities. Among these fungi, Penicillium janthinellum is a potential producer of secondary metabolites whose natural products have been noticed due to their various chemical structures and biological activities. This review summarizes the sources, distribution, bioactivities and structural characteristics of compounds isolated from P. janthinellum from 1980 to 2023. A total of 153 natural products have been isolated from P. janthinellum, of which 65 were new compounds. The compounds separated from P. janthinellum exhibit diverse skeletal chemical structures, concentrated in the categories of polyketides (40%), alkaloids (31%) and terpenoids (14%). P. janthinellum-derived compounds display attractive biological activities, such as cytotoxic, antibacterial, antifungal and antiviral activities. These results indicate that P. janthinellum is a potential fungus for producing bioactive secondary metabolites which can be used as precursors for new drugs.

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Section: Introductionmentioning

confidence: 99%

Penicillium janthinellum: A Potential Producer of Natural Products

Wang,

Li,

Wang

et al. 2024

Fermentation

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New piperazine derivatives helvamides B–C from the marine-derived fungus Penicillium velutinum ZK-14 uncovered by OSMAC (One Strain Many Compounds) strategy

Borkunov,

Leshchenko,

Berdyshev

et al. 2024

Nat. Prod. Bioprospect.

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Four extracts of the marine-derived fungus Penicillium velutinum J.F.H. Beyma were obtained via metal ions stress conditions based on the OSMAC (One Strain Many Compounds) strategy. Using a combination of modern approaches such as LC/UV, LC/MS and bioactivity data analysis, as well as in silico calculations, influence metal stress factors to change metabolite profiles Penicillium velutinum were analyzed. From the ethyl acetate extract of the P. velutinum were isolated two new piperazine derivatives helvamides B (1) and C (2) together with known saroclazin A (3) (4S,5R,7S)-4,11-dihydroxy-guaia-1(2),9(10)-dien (4). Their structures were established based on spectroscopic methods. The absolute configuration of helvamide B (1) as 2R,5R was determined by a combination of the X-ray analysis and by time-dependent density functional theory (TD-DFT) calculations of electronic circular dichroism (ECD) spectra. The cytotoxic activity of the isolated compounds against human prostate cancer PC-3 and human embryonic kidney HEK-293 cells and growth inhibition activity against yeast-like fungi Candida albicans were assayed. Graphical Abstract

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