Recent updates on the bioactive compounds of the marine-derived genus<i>Aspergillus</i>

Orfali, Raha; Aboseada, Mahmoud A.; Abdel‐Wahab, Nada M.; Hassan, Hossam M.; Perveen, Shagufta; Ameen, Fuad; Alturki, Eman A.; Abdelmohsen, Usama Ramadan

doi:10.1039/d1ra01359a

Cited by 42 publications

(24 citation statements)

References 116 publications

(214 reference statements)

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“…A meroditerpene, aszonapyrone B (11), was obtained from N. laciniosa [34]. Finally, eight compounds including ochratoxin A (12) and its methyl ester derivative (13), ochratoxin B ( 14), the dimeric naphthopyranones rubrosulphin (15) and its diacetate derivative (16), vioxanthin (17), viomellein (18), and xanthomegnin (19) were obtained from A. elegans [17]. It is worth mentioning that 17-19 present a similar scaffold to that of xanthones, which were previously described as potential efflux pump inhibitors [35].…”

Section: Compoundsmentioning

confidence: 99%

“…Compounds isolated from marine-derived fungi include alkaloids, polyketides, coumarins, polyphenols, acetophenones, and xanthones, among others [1,3,[7][8][9]. Specifically, the Aspergillus and Neosartorya genera have been extensively studied and recognized for the bioactive compounds they are able to produce [10][11][12][13][14][15]. Our group has been studying the potential of compounds isolated from these marine-derived fungi as potential antimicrobial agents, some of which have shown antibacterial activity against susceptible and resistant strains of clinically relevant bacteria [16][17][18][19].…”

Section: Introductionmentioning

confidence: 99%

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Metabolites from Marine-Derived Fungi as Potential Antimicrobial Adjuvants

et al. 2021

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Marine-derived fungi constitute an interesting source of bioactive compounds, several of which exhibit antibacterial activity. These acquire special importance, considering that antimicrobial resistance is becoming more widespread. The overexpression of efflux pumps, capable of expelling antimicrobials out of bacterial cells, is one of the most worrisome mechanisms. There has been an ongoing effort to find not only new antimicrobials, but also compounds that can block resistance mechanisms which can be used in combination with approved antimicrobial drugs. In this work, a library of nineteen marine natural products, isolated from marine-derived fungi of the genera Neosartorya and Aspergillus, was evaluated for their potential as bacterial efflux pump inhibitors as well as the antimicrobial-related mechanisms, such as inhibition of biofilm formation and quorum-sensing. Docking studies were performed to predict their efflux pump action. These compounds were also tested for their cytotoxicity in mouse fibroblast cell line NIH/3T3. The results obtained suggest that the marine-derived fungal metabolites are a promising source of compounds with potential to revert antimicrobial resistance and serve as an inspiration for the synthesis of new antimicrobial drugs.

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Section: Compoundsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Metabolites from Marine-Derived Fungi as Potential Antimicrobial Adjuvants

et al. 2021

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“…In a recent review summarizing the chemical and biological diversity of the secondary metabolites from the marine-derived genus Aspergillus , the major reported classes included anthracene and biphenyl derivatives, isoprenoids, alkaloids, butyrolactones, and others [ 22 ]. From the almost 2000 secondary metabolites reported from the members of the marine-derived Aspergillus genus, 332 compounds were associated with different bioactivities [ 22 ]. Among the ophiopolines, biphenyl derivatives, and alkaloids, 30% of these compounds showed exceptional anticancer activities and 27% of these compounds displayed anti-inflammatory and antimicrobial activities.…”

Section: Introductionmentioning

confidence: 99%

“…On the other hand, 10% of the compounds possessed an anti-diabetic effect, 8% showed anti-inflammatory effects, 8% possessed antioxidant properties, 4% of the compounds displayed antifungal effects, while 4% of the compounds showed antiviral activity. Finally, 9% of the compounds including biphenyl derivatives, butenolides, diterpenes, xanthones, diketopiperazines, and steroids, possessed other biological activities [ 22 ].…”

Section: Introductionmentioning

confidence: 99%

Asperopiperazines A and B: Antimicrobial and Cytotoxic Dipeptides from a Tunicate-Derived Fungus Aspergillus sp. DY001

2022

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Investigation of the cytotoxic fractions of the ethyl acetate extract of the fermentation broth of the tunicate-derived Aspergillus sp. DY001 afforded two new dipeptides, asperopiperazines A and B (1 and 2), along with the previously reported compounds (+)-citreoisocoumarin (3) and (−)-6,8-di-O-methylcitreoisocoumarin (4). Analyses of the 1D and 2D NMR spectroscopic data of the compounds supported their structural assignments. Asperopiperazine A (1) is a cyclic dipeptide of leucine and phenylalanine moieties, which are substituted with an N-methyl and an N-acetyl group, respectively. On the other hand, asperopiperazine B (2) is a cyclic dipeptide of proline and phenylalanine moieties with a hydroxyl group at C-2 of the proline part. The absolute configuration of the amino acid moieties in 1 and 2 were determined by Marfey’s analyses and DFT NMR chemical shift calculations, leading to their assignment as cyclo(l-NMe-Leu-l-NAc-Phe) and cyclo(d-6-OH-Pro-l-Phe), respectively. Asperopiperazines A and B displayed higher antimicrobial effects against Escherichia coli and Staphylococcus aureus than Candida albicans. Furthermore, compounds 1–4 displayed variable growth inhibitory effects towards HCT 116 and MDA-MB-231 cells, with asperopiperazine A as the most active one towards HCT 116.

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“…The genus Aspergillus , one of the main genera of marine-derived fungi, is rich in species [ 10 , 11 ], and marine-derived Aspergillus spp. produce structurally diverse secondary metabolites, including fatty acids, polyketides, alkaloids, and others, with a range of bioactivities [ 12 , 13 ].…”

Section: Introductionmentioning

confidence: 99%

Anti-Inflammatory Polyketides from an Alga-Derived Fungus Aspergillus ochraceopetaliformis SCSIO 41020

et al. 2022

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A new linear polyketide, named aspormisin A (1), together with five known polyketides (2−6), were isolated from the alga-derived fungus Aspergillus ochraceopetaliformis SCSIO 41020. Their structures were elucidated through a detailed comprehensive spectroscopic analysis, as well as a comparison with the literature. An anti-inflammatory evaluation showed that compounds 2, 5, and 6 possessed inhibitory activity against the excessive production of nitric oxide (NO) and pro-inflammatory cytokines in LPS-treated RAW 264.7 macrophages in a dose-dependent manner without cytotoxicity. Further studies revealed that compound 2 was active in blocking the release of pro-inflammatory cytokines (IL-6, MCP-1, and TNF-α) induced by LPS both in vivo and in vitro. Our findings provide a basis for the further development of linear polyketides as promising anti-inflammatory agents.

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Recent updates on the bioactive compounds of the marine-derived genusAspergillus

Abstract: The genus Aspergillus is widely distributed in terrestrial and marine environments.

Cited by 42 publications

References 116 publications

Metabolites from Marine-Derived Fungi as Potential Antimicrobial Adjuvants

Metabolites from Marine-Derived Fungi as Potential Antimicrobial Adjuvants

Asperopiperazines A and B: Antimicrobial and Cytotoxic Dipeptides from a Tunicate-Derived Fungus Aspergillus sp. DY001

Anti-Inflammatory Polyketides from an Alga-Derived Fungus Aspergillus ochraceopetaliformis SCSIO 41020

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