Recent Updates on the Phytochemistry and Pharmacological Properties of <i>Phlomis viscosa</i> Poiret

Yarmolinsky, Ludmila; Budovsky, Arie; Ben‐Shabat, Shimon; Khalfin, Boris; Gorelick, Jonathan; Bishitz, Yael; Miloslavski, Rachel; Yarmolinsky, Leonid

doi:10.1089/rej.2018.2093

Cited by 13 publications

(17 citation statements)

References 18 publications

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“…Many active phytochemicals of P. viscosa were identified by us previously [6]. The identified compounds are summarized in Table 1.…”

Section: Resultsmentioning

confidence: 99%

“…GC/MS analysis was used for the identification of volatile compounds as previously described by us [6]. GS/MS, a Varian CP 3800 GS/MS analytical system was applied.…”

Section: Identification Of Plant Compoundsmentioning

confidence: 99%

“…Diosmin, 1-octen-3-ol and himachala-2,4-diene, were purchased from S.L.Moran, Jerusalem, Israel. The solvents for HPLC tests were obtained from Merck, Kenilworth, N.J., U.S.A. Diosmetin was chemically synthesized as described previously [6].…”

Section: Compoundsmentioning

confidence: 99%

“…This combination creates a unique encounter between the two herbal populations, and a strong climatic gradient, resulting in highly-stressful conditions. Thus, the plants from the Judea region have the potential to contain high quantities of various phytochemicals with promising therapeutic properties [2][3][4][5][6][7][8][9]. As a consequence of this permanent stress, both endemic and widely distributed representatives of Mediterranean flora growing in the area have unique chemical contents in plants [4][5][6][7][8][9].…”

Section: Introductionmentioning

confidence: 99%

“…In fact, P. viscosa from the Judea region belongs to a distinct chemotype [9]. We mentioned some compounds of P. viscosa [6]. Table 1 summarizes data on compounds identified by us.…”

Section: Introductionmentioning

confidence: 99%

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Effect of Bioactive Phytochemicals from Phlomis viscosa Poiret on Wound Healing

Yarmolinsky¹,

Budovsky

Yarmolinsky³

et al. 2019

Plants

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Phlomis viscosa Poiret is an evergreen shrub growing in Israel, Turkey, Lebanon, and Syria with acknowledged pro-wound healing (WH) properties. In this study, we evaluated the pro-WH potential of selected compounds found in this plant. Among the pro-WH compounds (identified by us) was a combination of three chemicals—diosmin, 1-octen-3-ol, and himachala-2,4-diene which enhanced WH significantly both in in vitro and in vivo models. The determined phytochemicals combination could be used for the treatment of chronic wounds. The effect of the extracts, diosmin, 1-octen-3-ol on the secretion of pro-inflammatory cytokines, IL-6 (A) and IL-8 (B) by human dermal fibroblasts was significant (p < 0.001). In addition, the beneficial effect of extracts of P. viscosa and its phytochemicals on WH was evidenced by inhibiting the growth of several WH delaying microorganisms.

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“…Many active phytochemicals of P. viscosa were identified by us previously [6]. The identified compounds are summarized in Table 1.…”

Section: Resultsmentioning

confidence: 99%

“…GC/MS analysis was used for the identification of volatile compounds as previously described by us [6]. GS/MS, a Varian CP 3800 GS/MS analytical system was applied.…”

Section: Identification Of Plant Compoundsmentioning

confidence: 99%

Section: Compoundsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…In fact, P. viscosa from the Judea region belongs to a distinct chemotype [9]. We mentioned some compounds of P. viscosa [6]. Table 1 summarizes data on compounds identified by us.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations