Recent Updates on the Role of Nanoparticles in the Treatment of Viral Diseases

Javaid, Anam; Zahra, Duaa; Asim, Ayesha; Javaid, Nehdia; Ashfaq, Usman Ali

doi:10.1615/critrevtherdrugcarriersyst.2020034715

Cited by 6 publications

(3 citation statements)

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“…In the case of ophthalmic applications, nano-vesicular systems offer advantages over other delivery systems in promoting intimate contact with corneal and conjunctival surfaces, thus improving the ocular drug absorption [ 31 , 56 , 59 , 60 , 61 ]. For instance ganciclovir-loaded liposomes proposed in the treatment of ocular infections demonstrated a high drug transcorneal permeability, due to an interaction between liposomes and the corneal epithelial surface [ 56 ].…”

Section: Discussionmentioning

confidence: 99%

Ethosomal Gel for Topical Administration of Dimethyl Fumarate in the Treatment of HSV-1 Infections

Sicurella

Pula

Musiał

et al. 2023

IJMS

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The infections caused by the HSV-1 virus induce lesions on the lips, mouth, face, and eye. In this study, an ethosome gel loaded with dimethyl fumarate was investigated as a possible approach to treat HSV-1 infections. A formulative study was conducted, evaluating the effect of drug concentration on size distribution and dimensional stability of ethosomes by photon correlation spectroscopy. Ethosome morphology was investigated by cryogenic transmission electron microscopy, while the interaction between dimethyl fumarate and vesicles, and the drug entrapment capacity were respectively evaluated by FTIR and HPLC. To favor the topical application of ethosomes on mucosa and skin, different semisolid forms, based on xanthan gum or poloxamer 407, were designed and compared for spreadability and leakage. Dimethyl fumarate release and diffusion kinetics were evaluated in vitro by Franz cells. The antiviral activity against HSV-1 was tested by plaque reduction assay in Vero and HRPE monolayer cells, while skin irritation effect was evaluated by patch test on 20 healthy volunteers. The lower drug concentration was selected, resulting in smaller and longer stable vesicles, mainly characterized by a multilamellar organization. Dimethyl fumarate entrapment in ethosome was 91% w/w, suggesting an almost total recovery of the drug in the lipid phase. Xanthan gum 0.5%, selected to thicken the ethosome dispersion, allowed to control drug release and diffusion. The antiviral effect of dimethyl fumarate loaded in ethosome gel was demonstrated by a reduction in viral growth both 1 h and 4 h post-infection. Moreover, the patch test demonstrated the safety of the ethosomal gel applied on the skin.

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Section: Discussionmentioning

confidence: 99%

Ethosomal Gel for Topical Administration of Dimethyl Fumarate in the Treatment of HSV-1 Infections

Sicurella

Pula

Musiał

et al. 2023

IJMS

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“…It is still discussed whether Ag NPs can be applied in suppressing viruses. According to the recent literature it is active against Influenza A virus [ 61 ], respiratory syncytial virus (RSV) [ 62 ], Herpes simplex virus type 1 (HSV-1) [ 63 ] and Hepatitis B virus (HBV) [ 64 ].…”

Section: Applicationsmentioning

confidence: 99%

Hyaluronic Acid-Silver Nanocomposites and Their Biomedical Applications: A Review

et al. 2021

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For the last years scientific community has witnessed a rapid development of novel types of biomaterials, which properties made them applicable in numerous fields of medicine. Although nanosilver, well-known for its antimicrobial, anti-angiogenic, anti-inflammatory and anticancer activities, as well as hyaluronic acid, a natural polysaccharide playing a vital role in the modulation of tissue repair, signal transduction, angiogenesis, cell motility and cancer metastasis, are both thoroughly described in the literature, their complexes are still a novel topic. In this review we introduce the most recent research about the synthesis, properties, and potential applications of HA-nanosilver composites. We also make an attempt to explain the variety of mechanisms involved in their action. Finally, we present biocompatible and biodegradable complexes with bactericidal activity and low cytotoxicity, which properties suggest their suitability for the prophylaxis and therapy of chronic wounds, as well as analgetic therapies, anticancer strategies and the detection of chemical substances and malignant cells. Cited studies reveal that the usage of hyaluronic acid-silver nanocomposites appears to be efficient and safe in clinical practice.

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“…The central breakaway of nanovaccines is based on their ability to design pathogens' size and shape, creating a more realistic playing field for the immune system [2,10]. Biomimicry achieves this and helps the body when exposed to actual threats [11][12][13]. In addition, nanomaterials can absorb antigens and adjuvants, protecting them from decomposition and enabling them to be released in a controlled manner; this enhances immunogenicity while minimizing side effects [14,15].…”

Section: Introductionmentioning

confidence: 99%

The Intellectual Landscape of Nanovaccines: A Bibliometric Perspective on Scientific Progress and Future Directions

Jose,

M N,

R G

et al. 2024

Cureus

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This bibliometric study provides a comprehensive analysis of the burgeoning field of nanovaccine research, leveraging data sourced from Scopus and employing the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) flowchart for the meticulous screening, inclusion, and exclusion of relevant studies. Utilizing sophisticated bibliometric tools, such as Biblioshiny and CiteSpace, we dissected the expansive literature to unearth critical insights into the annual scientific output, identifying key contributors and pivotal publications that have shaped the domain. The analysis delineates the most influential authors, sources, and globally cited documents, offering a macroscopic view of the field's intellectual structure and growth trajectory. Trend topics and thematic mapping underscored the evolution of research foci, from fundamental immunological mechanisms to cutting-edge nanomaterial applications. Factorial analysis and keyword co-occurrence networks revealed the intricate associations and thematic concentrations within the literature. The study's robust methodology also pinpointed the keywords exhibiting the strongest citation bursts, signifying emergent areas of intense academic interest. Networks of cited authors illuminated collaborative patterns among scholars, while timeline network visualizations of country collaborations depicted the global interplay in nanovaccine development. Crucially, this study identified notable research gaps and practical implications, suggesting directions for future investigation and highlighting the translational potential of nanovaccines in public health and personalized medicine. This bibliometric investigation not only maps the current landscape but also charts a course for the trajectory of nanovaccine research, emphasizing its role as a cornerstone of innovative immunotherapeutic strategies.

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Recent Updates on the Role of Nanoparticles in the Treatment of Viral Diseases

Cited by 6 publications

References 0 publications

Ethosomal Gel for Topical Administration of Dimethyl Fumarate in the Treatment of HSV-1 Infections

Ethosomal Gel for Topical Administration of Dimethyl Fumarate in the Treatment of HSV-1 Infections

Hyaluronic Acid-Silver Nanocomposites and Their Biomedical Applications: A Review

The Intellectual Landscape of Nanovaccines: A Bibliometric Perspective on Scientific Progress and Future Directions

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