Abstract:We studed alpha decay half-lives of Pb isotopes in the range 178 ≤ A ≥ 220, whithin Gamow-like model (GLM) which is based on Gamow theory. The empirical formulae like Royer formula, Universal Decay Low (UDL), Viola-Seaborg formula (VSS), Semi-empirical formula for Poenaru (SemFIS) and Denisov & Khudenko formula (DEKH) are used to calculate alpha decay half-lives. The results are compared with experimental data, and also with other theoretical models, the results are in a good agreement was achieved with experimental data.