Recently spreading human monkeypox virus infection and its transmission during COVID-19 pandemic period: A travelers' prospective

Bhattacharya, Manojit; Dhama, Kuldeep; Chakraborty, Chiranjib

doi:10.1016/j.tmaid.2022.102398

Cited by 57 publications

(51 citation statements)

References 32 publications

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“…The MPX as a zoonotic disease is an uncommon viral disease that sometimes becomes life-threatening. It is a neglected disease, continuously emerging and reemmerging in Africa [ 4 , 13 ]. The monkeypox virus was first identified in monkey colonies in Copenhagen, Denmark, in 1958.…”

Section: Introductionmentioning

confidence: 99%

Evolution, epidemiology, geographical distribution, and mutational landscape of newly emerging monkeypox virus

et al. 2022

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Recent monkeypox (MPX) outbreaks are major ones in non-endemic countries. The present study analyzed molecular phylogenetics, divergence, epidemiology, the geographical distribution, entropy diversity of genome, mutational landscape, and evolution of the monkeypox virus (MPXV) genome and the current MPXV is entitled “hMPXV1.” We used different in-silico and statistical methods to study our objectives. The developed phylogram from molecular phylogenetics describes the origin and evolution of hMPXV1 of A, A.1, A.1.1, A.2, and B.1 lineages. The microevolution of B.1 lineage shows its evolution from May to August 2022. B.1 lineage is further adapting and showing more mutation and sub-lineages. The scatter plot of all lineages shows the clustering pattern of lineages and the divergence. We also developed two statistical models of confirmed cases and a diagram of the age-related pattern of infected cases to illustrate the epidemiology of the MPX outbreaks. The entropy diversity and mutational landscape of the hMPXV1 genome were analyzed in nucleotide and codon contexts. Our study has shown the in-depth evolution pattern of different lineages of the hMPXV1. We found B.1 lineage is associated with the current outbreaks. The mutational landscape informs about the slow mutation of the virus. Finally, the study might assists the new therapeutic development considering all the above points and would help the researcher to set up their future research directions.

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Section: Introductionmentioning

confidence: 99%

Evolution, epidemiology, geographical distribution, and mutational landscape of newly emerging monkeypox virus

et al. 2022

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“…Since May 7, 2022, an alarming epidemic of MPX has been occurring across Europe, Australia, and America in people who have no proven travel ties to endemic regions as well as many a countries were not endemic to MPXV. [2][3][4][5]9]. However, this was not predicted that MPX cases will rapidly rise and affect several countries in three months, and will pose global public health emergency [10,11].…”

Section: Introductionmentioning

confidence: 99%

Study of knowledge, attitude and anxiety in Kurdistan-region of Iraqi population during the monkeypox outbreak in 2022: An online cross-sectional study

Ahmed

Abdulqadir

Omar

et al. 2022

Preprint

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Background On July 23, the WHO declared the rapidly spreading monkeypox (MPX) epidemic as a Public Health Emergency of International Concern (PHEIC). This study attempted to assess the knowledge, attitude, and anxiety levels of the general population during the MPX outbreak. Methods An online cross-sectional survey was conducted during the period July 27 and July 30, 2022, using a convenience sampling method. The questionnaire was adapted and developed after an in-depth review of the previous studies. Results A total of 510 respondents participated in this study. 277 (54.3%) were male, 233 (45.7%) were female. Participants had insufficient knowledge of MPX with a mean and SD deviation 2.096 ± 1.359, 2.576 ± 1.466, having a normal attitude toward MPX 4.031 ± 1.645. Moreover, they had anxiety problems 32.382 ± 10.094. There were significant differences in the mean rank scores of the knowledge of respondents about MPX according to their gender, marital status, religion, level of education, and place of residence, with p-values of 0.009, 0.000, 0.000, 0.000, and 0.000, respectively. Also, there were significant differences in the mean rank scores of attitudes of respondents toward MPX according to their gender, level of education, place of residence, and age, with p-values of 0.011, 0.020, and 0.000, 0,029, respectively. Lastly, there were significant differences in the mean rank score of anxiety of respondents toward MPX according to their gender, marital status, religion, level of education, and place of residence, with p-values of 0.000, 0.009, 0.000, 0.000, and 0.000 respectively. Conclusion There is an urgent need to raise public awareness and manage people's emotional wellbeing. Taking into account the alarming scenario of rapid rise in MPX cases in many countries, any feasible pandemic probability of this disease amid the ongoing COVID-19 pandemic, proactive control measures, necessary preventive strategies and preparedness plans need to be executed on priority to counteract this global health emergency as well as safeguard the mental health of the general public. Appropriate policies and effectively prevent and control strategies along with disseminating correct information would explicitly help in counteracting MPX outbreaks and avoiding the infodemic's misinformation and disinformations which could pose unwarranted high fears and panic, and ultimately aid in safeguarding the mental health of the people.

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“…When determining the origin of an outbreak like this, it is critical to look at all conceivable channels of transmission (CDC 2022d;Haider et al 2022). Transmission and spread of human monkeypox virus infection have been earlier linked to travelers during previous outbreaks and travelers' perspectives (Bhattacharya et al 2022).…”

Section: Prevention Strategiesmentioning

confidence: 99%

Monkeypox: An Update on Current Knowledge and Research Advances

Chandran¹,

Dhama

Aslam

et al. 2022

J Exp Bio & Ag Sci

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The resurgence of the disease in humans that is very similar to smallpox called monkeypox (MPX) disease, caused by the monkeypox virus (MPXV), is the dominant topic of discussion in the scientific and popular press around the world right now. This is taking place as the world celebrates the historic accomplishments made in the fight against the Coronavirus Disease (COVID-19) pandemic MPX is currently thought to pose a risk to the general public's health, particularly in areas with high rates of MPXV infection and close human-wild animal contact. Despite the rarity of MPX outbreaks, they are often caused by human-to-human transmission, especially in households and healthcare settings. Recent decades have seen recurrent outbreaks of the MPX after the smallpox disease was declared eliminated and the consequent cessation of smallpox vaccination programs. MPX has presently spread to several countries throughout the world and posed a global public health emergency, with nearly 45000 confirmed cases in 96 countries and locations, and 12 deaths as of August 24, 2022. Even though this viral illness is thought to be self-limiting, its consequences and feasible pandemic potential seriously jeopardize public health. The main approach to avoiding MPX is to adopt appropriate prevention and control measures, increase awareness of risk factors, and inform the public of the steps they may take to reduce viral exposure. Scientific studies are currently looking at the viability and suitability of the MPX vaccination. This article presents a general introduction to MPXV / MPX along with progress in diagnosis, treatment, vaccination, and prevention and control strategies for tackling this global health emergency.

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Recently spreading human monkeypox virus infection and its transmission during COVID-19 pandemic period: A travelers' prospective

Cited by 57 publications

References 32 publications

Evolution, epidemiology, geographical distribution, and mutational landscape of newly emerging monkeypox virus

Evolution, epidemiology, geographical distribution, and mutational landscape of newly emerging monkeypox virus

Study of knowledge, attitude and anxiety in Kurdistan-region of Iraqi population during the monkeypox outbreak in 2022: An online cross-sectional study

Monkeypox: An Update on Current Knowledge and Research Advances

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