Récents progrès dans l’étiopathogénie de la scoliose idiopathique de l’adolescent et nouveaux concepts moléculaires

Letellier, Kareen; Azeddine, Bouziane; Blain, Sacha; Turgeon, Isabelle; Wang, Da Shen; Boiro, Mamadou Samba; Moldovan, Florina; Poitras, Benoît; Rivard, Charles‐Hilaire; Grimard, Guy; Parent, Stefan; Ouellet, Jean; Lacroix, Ginette; Moreau, Alain

doi:10.1051/medsci/20072311910

Cited by 21 publications

(8 citation statements)

References 41 publications

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“…Â çàâèñèìîñòè îò ñòåïåíè ïîðàaeåíèÿ ïîçâîíêà íàéäåíû è çàìåòíûå êîëåáàíèÿ â èõ ÷óâñòâèòåëüíîñòè ê ÌÒ. Ýòî ïîçâîëÿëî ïî òàêèì êðèòåðèÿì âûäåëèòü íåñêîëüêî ãðóïï áîëüíûõ, îäíîâðåìåííî ðàçëè÷àþùèõñÿ è ïî òÿaeåñòè ïðîöåññà [20,29].…”

Section: âëèÿíèå ìò íà ïàòîëîãèþ è ìåòàáîëèçì êîñòíîé òêàíèunclassified

Участие Мелатонина В Происхождении Патологических Процессов В Костной Ткани И Их Ограничении

Арушанян¹

2015

Эксп. и клин. фармакол.

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Мелатонин, продуцируемый эпифизом и клетками периферических тканей, посредством специфических рецепторов контролирует обмен в костной ткани и участвует в происхождении костной патологии. Современные экспериментальные доказательства его остеогенной активности позволяют рассматривать мелатонин в качестве потенциального лекарственного средства при различных видах заболеваний костей.

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Section: âëèÿíèå ìò íà ïàòîëîãèþ è ìåòàáîëèçì êîñòíîé òêàíèunclassified

Участие Мелатонина В Происхождении Патологических Процессов В Костной Ткани И Их Ограничении

Арушанян¹

2015

Эксп. и клин. фармакол.

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“…Scoliosis is found in about 0.2–0.6% of the general population, and in the majority of cases its cause remains unidentified; therefore, 70–90% of the cases of scoliosis are classified as idiopathic [ 1 ]. Its dominant feature is the fact that it develops spontaneously during the growth of the child, showing a progressive tendency.…”

Section: Introductionmentioning

confidence: 99%

Current insights into the aetiology of adolescent idiopathic scoliosis

Latalski

Danielewicz

Fatyga

et al. 2017

Arch Orthop Trauma Surg

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Scoliosis occurs in about 0.2–0.6% of the general population. In the majority of cases the cause of this entity remains mostly unidentified. The search for the causes covers almost all aspects of its possible origin. We collected and systematised the contemporary theories and concepts concerning the aetiology of adolescent idiopathic scoliosis. Genetic and hereditary factors are commonly accepted as possible causes; however, the identification of the single gene responsible for the development of this condition seems impossible, which suggests multifactorial mechanism of its formation. Dysfunctions of the nervous system are recognised risks related to the development of scoliosis, but they are classified as belonging to a separate aetiological category. Scoliosis develops at the quickest rate during the child’s growth spurt, which prompted the research on the role of the growth hormone in scoliosis aetiology. Melatonin is another hormone that is studied as a possible factor involved in development of this entity. In cases of progressive scoliosis, increased activity of calmodulin—a protein that regulates the levels of calcium ions—has been observed. The scientists have characterised numerous qualitative and quantitative changes in the composition of the tissue of intervertebral discs, spinal ligaments and paraspinal muscles. Some of the theories, explaining the nature of this entity, presented in this review seem to have only a purely theoretical value; their proliferation only confirms the fact that the actual nature of this condition has not been unveiled yet, and suggests its multifactorial aetiology.

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“…Πην ζπγθεθξηκέλα, ε δηαηαξαρή αθνξά ηηο Gi-πξσηεΐλεο ηεο θπηηαξηθήο κεκβξάλεο, νη νπνίεο ζπλδένληαη κε ηνπο ππνδνρείο ηηο κειαηνλίλεο θαη δηαδξακαηίδνπλ ζεκαληηθφ ξφιν ζηε θσζθνξπιίσζε ελδνθπηηάξησλ πξσηετλψλ. Η απμεκέλε θσζθνξπιίσζε ησλ Gi-πξσηετλψλ πξνθαιεί ηε δπζιεηηνπξγία κεηαβίβαζεο ηνπ νξκνληθνχ εξεζίζκαηνο εληφο ηνπ θπηηάξνπ [181][182][183][184][185]. ην κεραληζκφ απηφ ελδερνκέλσο λα εκπιέθνληαη θαη ηα νηζηξνγφλα 186.…”

unclassified

“…Με βάζε απηήλ ηελ παξαηήξεζε έρεη μεθηλήζεη πξνζπάζεηα θαηάηαμεο ησλ αζζελψλ κε ηδηνπαζή ζθνιίσζε ζε ηξεηο νκάδεο, αλάινγα κε ηελ θπηηαξηθή απάληεζε (cAMP) κεηά ηε δξάζε ηεο κειαηνλίλεο. Με ηνλ ηξφπν απηφ ζα θαζνξίδεηαη ε δπλακηθή αλάπηπμεο θαη εμέιημεο ηεο λφζνπ [181][182][183][184]. Η θαηάηαμε απηή γίλεηαη ζε κνξηαθφ επίπεδν κε ηε ιήςε δείγκαηνο αίκαηνο [181][182][183][184].…”

unclassified

“…Με ηνλ ηξφπν απηφ ζα θαζνξίδεηαη ε δπλακηθή αλάπηπμεο θαη εμέιημεο ηεο λφζνπ [181][182][183][184]. Η θαηάηαμε απηή γίλεηαη ζε κνξηαθφ επίπεδν κε ηε ιήςε δείγκαηνο αίκαηνο [181][182][183][184]. Πεξηγξάθεηαη επίζεο κηα δηαηαξαρή ζηνλ πνιιαπιαζηαζκφ ησλ νζηενβιαζηψλ, ε νπνία ζρεηίδεηαη θαη απηή κε ηελ απμεκέλε θσζθνξπιίσζε ησλ Gi-πξσηετλψλ θαη ηε δπζθνιία κεηαβίβαζεο ηνπ κελχκαηνο ηεο κειαηνλίλεο 187,188.…”

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Ο Ρόλος Της Μελατονίνης Και Της Καλμοδουλίνης Στην Αιτιοπαθογένεια Και Στην Πρόγνωση Της Ιδιοπαθούς Σκολίωσης Στα Παιδιά

Goultidis¹,

Γουλτίδης²

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Récents progrès dans l’étiopathogénie de la scoliose idiopathique de l’adolescent et nouveaux concepts moléculaires

Cited by 21 publications

References 41 publications

Участие Мелатонина В Происхождении Патологических Процессов В Костной Ткани И Их Ограничении

Участие Мелатонина В Происхождении Патологических Процессов В Костной Ткани И Их Ограничении

Current insights into the aetiology of adolescent idiopathic scoliosis

Ο Ρόλος Της Μελατονίνης Και Της Καλμοδουλίνης Στην Αιτιοπαθογένεια Και Στην Πρόγνωση Της Ιδιοπαθούς Σκολίωσης Στα Παιδιά

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