Receptor Binding Techniques in Neurotoxicology

Biochemical Approaches to Studying Neurotoxicity

“…In general, no matter what aspect of neurotransmitter dynamics is under investigation, this biochemical approach is strengthened by the inclusion of other nonbiochemical endpoints, such as behavioral, histological, or neurophysiological assessment (for example, Boyd et al, ; Fredricksson et al, ; Kanthasamy et al, ). Many good, detailed reviews have been written on the subject of neurotoxicity and neurotransmitter dynamics (Costa, ).…”

“…Moreover, the discussion and the majority of the references will focus on toxic compounds with environmental relevance, not toxins (plant-or animal-derived venoms or poisons) or pharmacologically relevant compounds. There are many reviews published in the last twenty years that address more specific aspects of neurochemical toxicology (e.g., Bondy, 1986;Abou-Donia et al, 1988;Costa et al, 1988;Costa, 1992).…”