Receptor modulators associated with the hypothalamus -pituitary-thyroid axis

Cheng, Xianbin; Zhang, Hong; Guan, Shanshan; Zhao, Qi; Shan, Yaming

doi:10.3389/fphar.2023.1291856

Cited by 7 publications

(2 citation statements)

References 79 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In addition to DIO2 , the DRGA SNP is also located ~ 68.7 kb upstream of the equally relevant thyroid stimulating hormone receptor ( TSHR ) gene. This receptor is constitutively expressed by follicular cells of the thyroid gland, where it mediates the response to thyroid stimulating hormone (TSH) released from the anterior pituitary, upregulating the production and release of thyroid hormone [ 10 ]. This receptor has also been found to be expressed by immune cells in peripheral lymphoid organs [ 11 ] and more recently, by natural killer cells [ 12 ], where TSH-TSHR signaling is thought to mediate processes including T cell maturation, and phagocytosis and cytokine production in dendritic cells.…”

Section: Introductionmentioning

confidence: 99%

A DIO2 missense mutation and its impact on fetal response to PRRSV infection

Ko,

Pasternak,

Mulligan

et al. 2024

BMC Vet Res

View full text Add to dashboard Cite

Background Porcine reproductive and respiratory syndrome virus 2 (PRRSV-2) infection during late gestation substantially lowers fetal viability and survival. In a previous genome-wide association study, a single nucleotide polymorphism on chromosome 7 was significantly associated with probability of fetuses being viable in response to maternal PRRSV-2 infection at 21 days post maternal inoculation. The iodothyronine deiodinase 2 (DIO2) gene, located ~ 14 Kilobase downstream of this SNP, was selected as a priority candidate related to fetal susceptibility following maternal PRRSV-2 infection. Our objectives were to identify mutation(s) within the porcine DIO2 gene and to determine if they were associated with fetal outcomes after PRRSV-2 challenge. Sequencing of the DIO2, genotyping identified variants, and association of DIO2 genotypes with fetal phenotypes including DIO2 mRNA levels, viability, survival, viral loads, cortisol and thyroid hormone levels, and growth measurements were conducted. Results A missense variant (p.Asn91Ser) was identified in the parental populations from two independent PRRSV-2 challenge trials. This variant was further genotyped to determine association with fetal PRRS outcomes. DIO2 mRNA levels in fetal heart and kidney differed by the genotypes of Asn91Ser substitution with significantly greater DIO2 mRNA expression in heterozygotes compared with wild-type homozygotes (P < 0.001 for heart, P = 0.002 for kidney). While Asn91Ser did not significantly alter fetal viability and growth measurements, interaction effects of the variant with fetal sex or trial were identified for fetal viability or crown rump length, respectively. However, this mutation was not related to dysregulation of the hypothalamic-pituitary-adrenal and thyroid axis, indicated by no differences in circulating cortisol, T4, and T3 levels in fetuses of the opposing genotypes following PRRSV-2 infection. Conclusions The present study suggests that a complex relationship among DIO2 genotype, DIO2 expression, fetal sex, and fetal viability may exist during the course of fetal PRRSV infection. Our study also proposes the increase in cortisol levels, indicative of fetal stress response, may lead to fetal complications, such as fetal compromise, fetal death, or premature farrowing, during PRRSV infection.

show abstract

Section: Introductionmentioning

confidence: 99%

A DIO2 missense mutation and its impact on fetal response to PRRSV infection

Ko,

Pasternak,

Mulligan

et al. 2024

BMC Vet Res

View full text Add to dashboard Cite

show abstract

“…согласно данным литературы, гипотиреоз нередко встречается среди пациентов с инфарктом миокарда с подъёмом сегмента St (импSt), в том числе получавших чрескожное коронарное вмешательство (чкв), и может служить прогностическим маркером неблагоприятных внутрибольничных событий и повышенной краткосрочной и долгосрочной смертности [6,7]. именно поэтому интерес исследователей к изучению функции щитовидной железы у пациентов с ибс, в том числе инфаркт миокарда (им), в последнее время возрастает [16,17].…”

Section: Introductionunclassified

Acute myocardial infarction in patients with concomitant hypothyroidism: clinical features and heart rate variability during inpatient treatment

Gridneva,

Chesnikova,

Safronenko

et al. 2024

jour

View full text Add to dashboard Cite

Objective: to evaluate the features of the clinical course, as well as heart rate variability (HRV) during inpatient treatment in patients with ST-segment elevation myocardial infarction (STEMI) and concomitant newly diagnosed hypothyroidism.Materials and methods: the study included 133 patients with STEMI aged 40 to 88 years who were admitted to the cardiology department. Depending on the presence of newly diagnosed hypothyroidism syndrome, all patients were divided into 3 groups: group 1 consisted of patients with STEMI without hypothyroidism syndrome (n=57), group 2A — patients with STeMI and subclinical hypothyroidism (n=42) and group 2B — patients with STeMI and manifest hypothyroidism (n=34). Clinical symptoms and complications in the acute period of MI were evaluated in all patients, and Holter ECG monitoring (XM ECG) was performed.Results: during hospital treatment, patients with concomitant manifest hypothyroidism showed more frequent development of cardiac arrhythmias such as paroxysmal atrial fibrillation (AF) (p<0.05), supraventricular extrasystole (NE), paroxysmal supraventricular tachycardia (LVT) (p<0,05). When assessing the risk of early complications in the acute period of MI, higher scores were recorded in patients with manifest hypothyroidism (p<0.05). The analysis of HRV indicators showed that in the studied patients with concomitant manifest hypothyroidism, despite the presence of an acute period of MI, activation of the parasympathetic link of the ANS (autonomic nervous system) prevails in the regulation of heart rhythm, unlike in patients of the control group and the group with subclinical hypothyroidism, in whom, on the contrary, the influence of the sympathetic link of the ANS prevails.Conclusion: during hospitalization, patients with manifest hypothyroidism were statistically significantly more likely to develop supraventricular cardiac arrhythmias, and a higher risk of cardiovascular complications in the acute period of MI was determined compared with both the control group and the group of patients with subclinical hypothyroidism. In patients with concomitant manifest hypothyroidism, the activation of the parasympathetic link of the ANS in the regulation of heart rhythm is more pronounced, in contrast to patients in the control group and the group with subclinical hypothyroidism, in whom, on the contrary, the influence of the sympathetic link of the ANS prevails.

show abstract

Tyrosine kinase inhibitor–induced hypothyroidism: mechanism and clinical implications

Wang,

et al. 2024

Eur J Clin Pharmacol

View full text Add to dashboard Cite

Receptor modulators associated with the hypothalamus -pituitary-thyroid axis

Cited by 7 publications

References 79 publications

A DIO2 missense mutation and its impact on fetal response to PRRSV infection

A DIO2 missense mutation and its impact on fetal response to PRRSV infection

Acute myocardial infarction in patients with concomitant hypothyroidism: clinical features and heart rate variability during inpatient treatment

Tyrosine kinase inhibitor–induced hypothyroidism: mechanism and clinical implications

Contact Info

Product

Resources

About