Receptor screening technologies in the evaluation of Amazonian ethnomedicines with potential applications to cognitive deficits

McKenna, Dennis J.; Ruiz, Juan M.; Hoye, Thomas R.; Roth, Bryan L.; Shoemaker, Alan T.

doi:10.1016/j.jep.2010.12.037

Cited by 13 publications

(11 citation statements)

References 65 publications

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“…Table 1 provides an overview of all studies included in the final sample and of all data elements used during the data analysis process. The 20 studies were distributed into the previously determined four categories as follows: Relevant plants worldwide [10,15,16,18,23,44,46,58,59,60] (ten studies); Relationship of mechanisms of action of potential biopharmaceuticals and their correlated diseases [10,11,15,20,23,44,46,58,59] (nine studies), Comparison among biopharmaceuticals and other drugs well established on the market [10,11,23,44,46] (five studies), Genetic variations and gene therapy perspectives related to mental disorders [9,28,58,93,96,100,134] (seven studies).…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Ethnopharmacological and genetic study on the treatment of mental disorders: a systematic review

Lima¹,

Pontes²,

Pinho³

et al. 2015

Int Arch Med

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Background: Popular medicine has been used to treat some diseases including mental disorders since the ancient times. The development of this powerful tool can bring to the actual world some benefits to improve the way of taking care of mental illnesses. Objective: To show relevant studies about biopharmaceuticals and to infer the equivalence of using biopharmaceuticals, regarding to efficacy and safety as the chemical-type drugs in the treatment for mental disorders, assessing whether there are biomolecules that might work as biopharmaceuticals to treat, cure or mitigate different mental disorders. Methods: A systematic review from 01.01.2004 to 25.28.2014 was performed on the databases PubMed, Scopus and Science Direct. The search was performed with the descriptor ''mental disorders'' and with the keywords ''biopharmaceuticals'' and ''biomolecules''. The information pertinent to the study was selected, categorized and analyzed. Of the 339 articles found, 20 met the eligibility criteria. Results: Eastern culture, followed by Amazonian region concentrated most of the species related with popular treatment of mental disorders. Several species were revealed to act upon receptors or neurotransmitters in the Central Nervous System (CNS), which, sometimes, is a similar mechanism of action of a lot of well-known synthetic drugs on the market. It was also highlighted the use of the genetic knowled

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Section: Resultsmentioning

confidence: 99%

“…Genetic Study. cology, ethnopharmacological research has uncovered a wide spectrum of CNS-active compounds ranging from sedatives to anxiolytics to analgesics to hallucinogens [15].…”

Section: Treatment Of Mental Disorders;mentioning

confidence: 99%

Ethnopharmacological and genetic study on the treatment of mental disorders: a systematic review

Lima¹,

Pontes²,

Pinho³

et al. 2015

Int Arch Med

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“…A variety of modern central nervous system targeting monocompound drugs have been originally identified in psychoactive plants and natural products, which are components of many traditional medicinal systems [34]. As many traditional medicinal formulations are based on the combined and synergistic activities of several substances that enhance their pharmacological properties, investigations of the resulting mechanisms of action could help to uncover new medications for the treatment of diseases of the nervous system and mental illnesses.…”

Section: Multicomponent Interventions For Multifactorial Diseasesmentioning

confidence: 99%

An update on the strategies in multicomponent activity monitoring within the phytopharmaceutical field

Gostner¹,

Wrulich²,

Jenny³

et al. 2012

Z Phytother

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“…She reported almost 6800 specimens citing medicinal uses among the 2,500,000 specimens of Harvard Herbarium, despite excluding those published or likely to be known already. Since von Reis enumerated the advantages of searching herbaria for novel reports of use, herbarium surveys have become a minor but established source of ethnobotanical data (Bedigian 2004; de la Torre et al 2012; Fantz 1991; Jenks and Kim 2013; Krishna et al 2014; Lampe 1986; Lira and Caballero 2002; Lukhoba et al 2006; McKenna et al 2011; Prakash 2011; Van Andel et al 2014; Vickery 1990; Shinde and Prakash 2015). Since herbaria are rich in historical data, they have found particular use in documenting change (Nesbitt 2014).…”

Section: Introductionmentioning

confidence: 99%

Comparison of Herbarium Label Data and Published Medicinal Use: Herbaria as an Underutilized Source of Ethnobotanical Information

Souza

Hawkins

2017

Econ Bot

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The use of herbarium specimens as vouchers to support ethnobotanical surveys is well established. However, herbaria may be underutilized resources for ethnobotanical research that depends on the analysis of large datasets compiled across multiple sites. Here, we compare two medicinal use datasets, one sourced from published papers and the other from online herbaria to determine whether herbarium and published data are comparable and to what extent herbarium specimens add new data and fill gaps in our knowledge of geographical extent of plant use. Using Brazilian legumes as a case study, we compiled 1400 use reports from 105 publications and 15 Brazilian herbaria. Of the 319 species in 107 genera with cited medicinal uses, 165 (51%) were recorded only in the literature and 55 (17%) only on herbarium labels. Mode of application, plant part used, or therapeutic use was less often documented by herbarium specimen labels (17% with information) than publications (70%). However, medicinal use of 21 of the 128 species known from only one report in the literature was substantiated from independently collected herbarium specimens, and 58 new therapeutic applications, 25 new plant parts, and 16 new modes of application were added for species known from the literature. Thus, when literature reports are few or information-poor, herbarium data can both validate and augment these reports. Herbarium data can also provide insights into the history and geographical extent of use that are not captured in publications.Electronic supplementary materialThe online version of this article (doi:10.1007/s12231-017-9367-1) contains supplementary material, which is available to authorized users.

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Receptor screening technologies in the evaluation of Amazonian ethnomedicines with potential applications to cognitive deficits

Cited by 13 publications

References 65 publications

Ethnopharmacological and genetic study on the treatment of mental disorders: a systematic review

Ethnopharmacological and genetic study on the treatment of mental disorders: a systematic review

An update on the strategies in multicomponent activity monitoring within the phytopharmaceutical field

Comparison of Herbarium Label Data and Published Medicinal Use: Herbaria as an Underutilized Source of Ethnobotanical Information

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