Receptors and Binding Proteins for Insulin and Insulin-Like Growth Factors in the Placenta of Healthy Mothers and Mothers with Insulin-Dependent Diabetes Mellitus

Weber, Milena; Baričević-Jones, Ivona; Masnikosa, Romana; Filimonović, Dejan; Miković, Željko; Nedić, Olgica

doi:10.2478/v10011-008-0030-3

Cited by 3 publications

(1 citation statement)

References 37 publications

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“…Indeed, this mechanism may be a potential cause of rare forms of juvenile diabetes (44). For example, PERK deficient pancreatic beta cells are more susceptible to ER stress induced apoptosis.…”

Section: Endoplasmic Reticulum Stress In Diabetes Mellitus Pathogenesismentioning

confidence: 99%

Genetic Predisposition for Type 1 Diabetes Mellitus - The Role of Endoplasmic Reticulum Stress in Human Disease Etiopathogenesis

Stankov¹

2010

Journal of Medical Biochemistry

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Kratak sadr`aj: Stalni porast incidence diabetes mellitusa u svetu i u na{oj zemlji, predstavlja zna~ajan sti mulans za ubrza nje nau~nih otkri}a koja doprinose uvidu u kom pleksne mehanizme uklju~ene u etiopatogenezu ovog multifaktorijalnog oboljenja. Brojna istra`ivanja ukazuju da je stres endoplaz matskog retikuluma zna~ajan faktor u patogenezi dijabetesa, koji doprinosi apoptozi beta }elija pankreasa, kao i rezistenciji na insulin. Wolfram sindrom predstavlja autozomno recesivno neurodegenerativno oboljenje, koje karakteri{e razvoj insulin-zavisnog diabetes mellitusa i progresivne atrofije opti~kog nerva. Wolfram sin drom je retko neurodegenerativno genetsko oboljenje, nepoznate patogeneze. Gen za wolframin (WFS1 lokus) mapiran je na hromozomu 4p16.1, me|utim postoje zna~ajni dokazi za genetsku heterogenost, uz prisustvo delecija u mitohon drijal nom genomu kod malog procenta pacijenata. Analize sprovedene primenom strategije pozicionalnog kloniranja dovele su do identifikacije drugog lokusa (WFS2) i uzro~ne mutacije CISD2 gena za WFS2, na hro mozomu 4q24, koji kodira mali intermembranski protein lokalizovan u endoplazmatskom retikulumu. Na{i rezultati su dobijeni analizom porodica koje pripadaju specifi~noj populaciji, sa ~lanovima obolelim od Wolframovog sindro ma (WFS1). Identifikovali smo novu genetsku alteraciju WFS1 gena, dvostruku »nonsynonymous & frameshift« mu taciju, kao dodatnu potvrdu genetske heterogenosti ovog sindroma. Novoidentifi ko vane mutacije doprinose ra zumevanju patogeneze Wolfram sindroma, kao i utvr|i va nju kompleksnih mehanizama ukljue nih u nastanak diabetes mellitusa.

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Section: Endoplasmic Reticulum Stress In Diabetes Mellitus Pathogenesismentioning

confidence: 99%

Genetic Predisposition for Type 1 Diabetes Mellitus - The Role of Endoplasmic Reticulum Stress in Human Disease Etiopathogenesis

Stankov¹

2010

Journal of Medical Biochemistry

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Direct C2-Alkylation of Azoles with Alcohols and Ethers through Dehydrogenative Cross-Coupling under Metal-Free Conditions

et al. 2011

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A metal-free novel, simple, and highly efficient method for the direct C2-alkylation of azoles with alcohols and ethers has been developed on the basis of an oxidative C-H activation process. The dehydrogenative C-C cross-coupling reactions of α-position sp(3) C-H in alcohols and ethers with the 2-position sp(2) C-H in azoles proceeded smoothly in the presence of tert-butyl hydroperoxide (TBHP) under neat reaction conditions, which generated the corresponding products in good yields.

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Influence of placental mannose/N-acetyl glucosamine-binding proteins on the interaction of insulin and insulin-like growth factors with their receptors

Nedić

Filimonović

Miković

et al. 2011

Biochemistry Moscow

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Placenta is a source of carbohydrate-binding proteins that function as molecular scavengers, but they could also be involved in interactions that assist in metabolic control. Mannose/N-acetyl-glucosamine (Man/GlcNAc)-binding proteins from placenta were isolated and their reactivity towards placental insulin and insulin-like growth factor receptors (IR and IGF-Rs) was analyzed. The lectins reduced the binding of insulin and IGF-I in a dose-dependent manner, while almost no effect was observed on the binding of IGF-II. The shape of the inhibition curves changed, suggesting altered binding specificity. The presence of sugar could not reverse completely the effect of the lectins, implicating both lectin-sugar and protein-protein conformational recognition. Since biological molecules in our experimental system were those that are in close relation in vivo, placental Man/GlcNAc-specific lectins may be regarded as potential allosteric modulators of ligand-receptor interactions in a system of homologous ligands, selectively affecting only binding to tyrosine kinase type receptors (IR and IGF-1R).

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Receptors and Binding Proteins for Insulin and Insulin-Like Growth Factors in the Placenta of Healthy Mothers and Mothers with Insulin-Dependent Diabetes Mellitus

Cited by 3 publications

References 37 publications

Genetic Predisposition for Type 1 Diabetes Mellitus - The Role of Endoplasmic Reticulum Stress in Human Disease Etiopathogenesis

Genetic Predisposition for Type 1 Diabetes Mellitus - The Role of Endoplasmic Reticulum Stress in Human Disease Etiopathogenesis

Direct C2-Alkylation of Azoles with Alcohols and Ethers through Dehydrogenative Cross-Coupling under Metal-Free Conditions

Influence of placental mannose/N-acetyl glucosamine-binding proteins on the interaction of insulin and insulin-like growth factors with their receptors

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