Receptors for human γG Globulin on human neutrophils

Messner, Ronald P.; Jelinek, J.

doi:10.1172/jci106435

Cited by 219 publications

(74 citation statements)

References 20 publications

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“…15 %) indicated that granulocytes do not easily rosette, using the assay described here. Messner and Jelinek (1970), showed that granulocyte Fc receptors could be more easily identified using HE coated with the rare Ripley (anti-CD) serum, whereas normal anti-D-coated HE detected similar numbers of granulocyte HEA-RFC to those found here.…”

Section: Discussionsupporting

confidence: 69%

“…Other authors (Messner andJelinek, 1970, Fr0land et al, 1974a) have observed similar inhibition of HEA-RFC, but Dickler and Kunkel (1972) (Dickler and Sachs, 1974).…”

Section: Discussionmentioning

confidence: 72%

“…Receptors for human IgG have been demonstrated on human leucocytes including monocytes Fudenberg, 1968, Abramson et al, 1970a), polymorphonuclear neutrophils (Messner and Jelinek, 1970) and a subpopulation of lymphocytes (Brain and Marston, 1973;Fr0land et al, 1974a). That the receptor recognizes the Fc fragment of IgG has been demonstrated by the inhibition of IgG binding to cells by isolated Fc but not Fab or F(ab')2 fragments (Abramson et al, 1970b;Messner and Jelinek, 1970;Fr0land et al, 1974a).…”

mentioning

confidence: 99%

“…That the receptor recognizes the Fc fragment of IgG has been demonstrated by the inhibition of IgG binding to cells by isolated Fc but not Fab or F(ab')2 fragments (Abramson et al, 1970b;Messner and Jelinek, 1970;Fr0land et al, 1974a). Although Fc receptors are important for the phagocytosis of antigen-antibody complexes by monocytes and macrophages, Fudenberg, 1968, Huber, Douglas andFudenberg, 1969) and in antibody-dependent lymphocyte-mediated cytotoxicity (Dickler, 1974;Wisl0ff, Fr0land and Michaelson, 1974) the functional significance of Fc receptors in vivo still remains unclear.…”

mentioning

confidence: 99%

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Receptors for human immunoglobulin on acute myeloid leukaemic leucocytes

Ridway¹,

Taylor²,

Freeman³

et al. 1976

Br J Cancer

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Section: Discussionsupporting

confidence: 69%

“…Other authors (Messner andJelinek, 1970, Fr0land et al, 1974a) have observed similar inhibition of HEA-RFC, but Dickler and Kunkel (1972) (Dickler and Sachs, 1974).…”

Section: Discussionmentioning

confidence: 72%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Receptors for human immunoglobulin on acute myeloid leukaemic leucocytes

Ridway¹,

Taylor²,

Freeman³

et al. 1976

Br J Cancer

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“…(Henson, 1969;Messner and Jellinek, 1970;Zipursky and Brown, 1974), under present conditions they did not form stable EA rosettes, either in suspension or after they had adhered in culture. They were identified by nuclear morphology and were counted on the culture dishes prepared in (ii) above.…”

Section: Methodsmentioning

confidence: 68%

Effect of X-irradiation on host-cell infiltration and growth of a murine fibrosarcoma

Evans¹

1977

Br J Cancer

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Summary.-Whole body X-irradiation (400 rad) of C57BL mice, either before or after i.m. implantation of the syngeneic fibrosarcoma, FS6, influenced both the growth of the tumours and their cellular composition, particularly their macrophage content. Pre-irradiation resulted in slower initial growth of tumours, and a concomitant lack of host -cell infiltration, but when tumours began to grow at a rate parallel to controls infiltration by host cells was demonstrable. Similarly, irradiation of the tumourbearing host resulted in a temporary cessation of growth, and a decrease in the macrophage content, which did not return to control levels for 2-3 weeks after irradiation. (Evans, 1972). Moreover, for a given tumour, the level was also shown to be relatively constant, both during the growth of the tumour and when it was transplanted to a syngeneic recipient.In an attempt to further our understanding of the mechanisms which affect tumour growth and the cellular composition of the tumour, mice were exposed to whole-body irradiation either before the C57BL fibrosarcoma, FS6, was implanted, or after the tumour had been growing for several days. MATERIALS AND METHODSMice.-Eight 10-week-old male C57BL mice, weighing 18-24 g, were used for growth of the syngeneic FS6 tumour, which was benzpyrene-induced in 1969 and maintained by regular passage in syngeneic mice by injecting cells into the musculature of the right hind leg. This tumour is highly immunogenic, as shown either by concomitant immunity techniques or by rejection of large numbers of challenge tumour cells after surgical excision of the primary tumour.Tumnour.-Cell suspensions from intramuscular FS6 tumours were prepared by a modification of the technique fully described elsewhere (Evans, 1972). Trypsin was omitted from the enzyme solution and the percentage of collagenase was increased to 0 2%. Deoxyribonuclease (Sigma) was also incorporated at 1 ,ug/ml. The reason for omitting trypsin was that separation of adherent, non-neoplastic cells (see below) was achieved more readily if the FS6 tumour cells had not been previously exposed to trypsin. In all experiments 106 tumour cells were injected i.m. This size of inoculum gave a

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Calcium pyrophosphate dihydrate crystal deposition disease—1975

McCarty¹

1976

Arthritis & Rheumatism

222

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Enough has been learned about the peculiar arthropathy associated with calcium pyrophosphate dihydrate (CPPD) crystal deposition over the past decade to justify holding a symposium. Reasonable data relating to the prevalence of the condition and to its multifaceted clinical presentations, radiologic appearance, pathology, triggering mechanisms for the acute attacks, mechanisms of induction of joint inflammation, and genetics are presented in this symposium. But, as with most diseases, we are still blind men palpating the e!ephant. This article is intended to be a status report. An approximate description of the shape and size of the b e m is presented here, together with speculation as to its genesis and thoughts regarding the directions of, need for, and possible significance of further palpation by scientists and clinicians.

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Receptors for human γG Globulin on human neutrophils

Abstract: A B S T R A C T Cell

Cited by 219 publications

References 20 publications

Receptors for human immunoglobulin on acute myeloid leukaemic leucocytes

Receptors for human immunoglobulin on acute myeloid leukaemic leucocytes

Effect of X-irradiation on host-cell infiltration and growth of a murine fibrosarcoma

Calcium pyrophosphate dihydrate crystal deposition disease—1975

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