Receptors for Neuronal or Endocrine Signalling Molecules as Potential Targets for the Control of Insect Pests

Peptidomics of Neuropeptidergic Tissues of the Tsetse FlyGlossina morsitans morsitans

“…ETH is released from the Inka cells of the trachea upon stimulation by EH and/or Crz [63], and acts on the CNS. While we could not detect EH in tsetse fly tissues, we could detect the presence of a single truncated ETH peptide (ETH [3][4][5][6][7][8][9][10][11][12][13][14][15][16][17] ) in the brain (Supplementary Data).…”

“…Nevertheless, to date, insecticide resistance has not yet been observed in tsetse flies. As neuropeptides and their receptors regulate almost all vital biological processes such as development, behavior, metabolism, and reproduction, they are ideal targets for the generation of new pesticides [15]. A first major step in this direction was taken recently with the publication of the genome sequence of Glossina morsitans morsitans [1], which predicted 39 neuropeptide precursor-encoding genes and 43 genes that encode a neuropeptide receptor.…”

Characterization and pharmacological analysis of two adipokinetic hormone receptor variants of the tsetse fly, Glossina morsitans morsitans

“…Due to its pleiotropic actions, the AKH signaling system may become an interesting target for the development of new insecticides that are detrimental for the fly's and trypanosome's fitness, which are considered as one of the best ways to combat trypanosomiasis (Aksoy, 2003;De Vooght et al, 2014). The potential of neuropeptidergic signaling systems as targets for new insecticides has been highlighted because of their regulatory function in most physiological processes during an insect's life (G€ ade and Goldsworthy, 2003;Scherkenbeck and Zdobinsky, 2009;Verlinden et al, 2014). So far, none of the tsetse neuropeptidergic signaling systems has been pharmacologically studied.…”

Mosquito Peptide Hormones

“…Trypsin modulating oostatic factor (TMOF) is a proline rich, 10 amino acid peptide identified in Ae. aegypti that is often discussed as a peptidyl regulator of blood meal digestion and egg formation in mosquitoes (Borovsky et al, 1990; Verlinden et al, 2014). However, TMOF is not included in Table 1 or further discussed here because it matches a 10 amino acid sequence of the vitelline envelope protein (Lin et al, 1993), which clearly is not a peptide hormone precursor protein.…”

“…As a result, most reviews focus on either: (1) processes that peptide hormones have roles in regulating like metabolism (Baker and Thummel, 2007; Broughton and Partridge, 2009), moulting and metamorphosis (Smith and Rybczynski, 2012; White and Ewer, 2014), and water balance (Dow and Davies, 2006) or (2) particular types of peptide hormones such as FMRFamides (Nichols, 2003), ILPs (Antonova et al, 2012), or PRXamides (Jurenka, 2015). A few recent summaries discuss peptide hormone functions more broadly but they primarily emphasize nonmosquito species, which results in a number of studies from the mosquito literature being uncited (Hauser et al, 2008; Näassel and Winther, 2010; Verlinden et al, 2014). Our own assessment identifies functional data in one or more mosquito species for about a third of the entries in Table 1.…”