Recherche de substances à activité immunorégulatrice sur le lymphocyte T humain: nouveaux composés thiadiazabicycliques et étude comparative avec le tétramisole

New Heterofused Thiazolo/Pyrazinedione Hybrids as Promising Building Blocks for Anticancer Drug Development: Synthesis, Biological and Drug‐Likeness Evaluation

“…Several studies that involve heterocycle synthesis have led to powerful therapeutic agents. However, in some cases, promising heterocyclic compounds such as Levamisole®, an imidazo[2,1‐ b ][1,3]thiazole drug with potent antihelminthic and immunomodulatory effects, [1] have shown serious adverse effects [2] . Such adverse effects and the potential development of drug‐resistance make it necessary to join efforts to access better and more selective chemotherapeutic agents.…”

“…However, in some cases, promising heterocyclic compounds such as Levamisole®, an imidazo[2,1-b] [1,3]thiazole drug with potent antihelminthic and immunomodulatory effects, [1] have shown serious adverse effects. [2] Such adverse effects and the potential development of drug-resistance make it necessary to join efforts to access better and more selective chemotherapeutic agents. In the search for novel bioactive compounds, molecular hybridization has recently emerged as a potent synthetic strategy.…”