Recherches Sur La Structure De La Membrane Nucléaire

Baud, C A

doi:10.1159/000140802

Cited by 14 publications

(4 citation statements)

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“…There were such observations reported before Garnier's thesis (see Altmann (3), De Groot, La Gasse, and Sebruyns (17), Henry (27), Krabbe (31), and Wilson (52) for some of the older literature) and many additional studies have been reported during the 60 year interval between the work of Gamier and Hsu and Lou and Wendt. Various aspects of the nudeocytoplasmic relationship have been covered in recent reviews (Baud (7), Bloch (10), Briggs and King (14), Gates (22), Hertl (28), Kurnick (32), Mazia (36), Stich (44), and Vincent (47)), and no attempt will be made here to review the subject. The admirable report of Hertl (28) carefully compares many of the opinions about the structure and function of the nucleolus (nucleolar apparatus) and discusses the transfer of nuclear and nucleolar material into the cytoplasm.…”

Section: The Incidence Of Nuclear "Blebbing"--manymentioning

confidence: 99%

“…At least 3 anatomic mechanisms of such extrusions have been described. (a) A nuclear vesicle ("bleb" or "pocket") is said to form at the nuclear membrane and the "bleb" then ruptures or is dispersed in some fashion into the cytoplasm (7,30,31,51). (b) The nuclear membrane is described as opening temporarily ("Schleusenmechanismus" of Berg) and such openings are associated with transfer of nuclear material into the cytoplasm (3)(4)(5)8).…”

Section: The Incidence Of Nuclear "Blebbing"--manymentioning

confidence: 99%

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Electron Microscope Studies of Nuclear Extrusions in Pancreatic Acinar Cells of the Rat

Clark

1960

The Journal of Cell Biology

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This paper describes "blebs" protruding from the surface of the nucleus into the cytoplasm. The "blebs" are separated from the cytoplasm by 2 membranes which are continuous with the outer and inner nuclear membranes. The "blebs" contain 3 structurally distinct substances. Two of these substances (13 and 7 substances) are similar to extranucleolar karyoplasm and nucleolar material. The other substance (a substance) is present in every "bleb," but it cannot be readily compared to a recognizable nuclear structure. Cytoplasmic vesicles are described that are apparently different from the Golgi vesicles or the vesicular component of the ergastoplasm. It is suggested that these vesicles may be of nuclear "bleb" origin.A dark karyoplasmic zone extending from the region of the nucleolus into the nuclear "bleb" is shown. This zone may be similar in some respects to the preformed pathway ("Leitbahn") described by Altmann (3) and Hertl (28) and could reflect movement of nuclear material from the nucleolar region into the cytoplasm.The "blebs" are thought to be homologous to structures described by many light microscopists, but they are considerably larger than the nuclear "blebs" described previously by electron microscopists.The transfer of microscopically visible material from the nucleus into the cytoplasm has been described from time to time for many years and has been suggested as one of the possible mechanisms whereby the interphase nucleus could bring its influence to bear on cytoplasmic function. Observations described in this paper of vesicular structures, apparently budding out from the nucleus into the cytoplasm, provide further evidence of possible transfer of nuclear material into the cytoplasm. The size and morphology of these nuclear extrusions indicate that they correspond to the structures described by m a n y light microscopists (3-5, 7, 8, 21, 27, 28, 30, 31, 33, 34, 39, 43, 51), but the extrusions seem to be much larger than those described previously by electron microscopists (1,2,6,17,23,24,37,53).

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Section: The Incidence Of Nuclear "Blebbing"--manymentioning

confidence: 99%

Section: The Incidence Of Nuclear "Blebbing"--manymentioning

confidence: 99%

Electron Microscope Studies of Nuclear Extrusions in Pancreatic Acinar Cells of the Rat

Clark

1960

The Journal of Cell Biology

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“…However, the fact that this does not hold true for other material may be the reason why, in cases where the membrane is seen only in fixed condition, doubt has arisen as to the existence of an in vivo nuclear membrane. With this in mind Baud (1953) appears to be justified in his conclusion that the nuclear membrane is visible in some cells in the living condition, while in other cells indirect methods, such as phase contrast microscopy and microdissection, can be employed to show its presence. In spite of the fact that it cannot be demonstrated under all conditions in all material, the existence of the nuclear membrane has generally been accepted as representing an in vivo structure separating the nuclear con tents from the cytoplasm.…”

Section: Discussionmentioning

confidence: 99%

“…Another view long since abandoned, which was held by early microscopists (see Wilson 1937), claimed that the nuclear membrane was simply a denser portion of the protoplasm, with the nucleus being conceived only as a localized area within the common structural framework. Baud (1953) has discussed this problem at length and has shown that the existance of the nuclear membrane can be established by the fact that it is ob servable under in vivo conditions employing phase contrast optics (Zollinger 1948). Such evidence is strengthened by the findings obtained by the use of in direct procedures, the most convincing of which is microdissection (Chambers 1924).…”

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confidence: 99%