Recipient and Perioperative Risk Factors Associated With Liver Transplant Graft Outcomes

Sirivatanauksorn, Yongyut; Taweerutchana, Voraboot; Limsrichamrern, Somchai; Kositamongkol, Prawat; Mahawithitwong, Prawej; Asavakarn, S.; Tovikkai, Chutwichai

doi:10.1016/j.transproceed.2012.01.065

Cited by 16 publications

(11 citation statements)

References 16 publications

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“…(4) According to Cameron et al, (39) Hot ischemia time in excess of 40 minutes increased the risk of EAD and PNF. Hot ischemia times in excess of 45 minutes were also incriminated as independent risk factors for the same outcomes by Sirivatanauksorn et al (44) Recipient related factors are also known to be associated with EAD. (7,43,44) Recipient age and race have been arguably recognized as risk factors.…”

Section: Risk Factors For Early Allograft Dysfunction and Primary Nonmentioning

confidence: 90%

“…Hot ischemia times in excess of 45 minutes were also incriminated as independent risk factors for the same outcomes by Sirivatanauksorn et al (44) Recipient related factors are also known to be associated with EAD. (7,43,44) Recipient age and race have been arguably recognized as risk factors. (5,39) Younger recipient age has been associated with lower risks of EAD and PNF.…”

Section: Risk Factors For Early Allograft Dysfunction and Primary Nonmentioning

confidence: 90%

“…Steatosis macro ≥30% (34)(35)(36) Hot ischemia time >40 minutes (39) >45 minutes (44) Young recipients (tend to receive organs from expanded criteria donors) (5,8,39,43) Expanded criteria donors (1,4,7) Cold ischemia time >10 hours (8,43) Age >49 years (8,43) >65 years (30) …”

Section: Surgical Procedures Recipientmentioning

confidence: 99%

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Primary graft dysfunction of the liver: definitions, diagnostic criteria and risk factors

Neves

Rusi

Díaz

et al. 2016

Einstein (São Paulo)

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Primary graft dysfunction is a multifactorial syndrome with great impact on liver transplantation outcomes. This review article was based on studies published between January 1980 and June 2015 and retrieved from PubMed database using the following search terms: "primary graft dysfunction", "early allograft dysfunction", "primary non-function" and "liver transplantation". Graft dysfunction describes different grades of graft ischemia-reperfusion injury and can manifest as early allograft dysfunction or primary graft non-function, its most severe form. Donor-, surgery-and recipient-related factors have been associated with this syndrome. Primary graft dysfunction definition, diagnostic criteria and risk factors differ between studies.

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Section: Risk Factors For Early Allograft Dysfunction and Primary Nonmentioning

confidence: 90%

Section: Risk Factors For Early Allograft Dysfunction and Primary Nonmentioning

confidence: 90%

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Primary graft dysfunction of the liver: definitions, diagnostic criteria and risk factors

Neves

Rusi

Díaz

et al. 2016

Einstein (São Paulo)

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“…Initial poor function is a borderline syndrome and is reversible. PNF is rare, with an incidence rate of 0.9%-7.2%, but it is potentially fatal when it leads to irreversible graft failure (8)(9)(10). Therefore, early diagnosis and retransplantation are important to avoid potentially devastating consequences of PNF.…”

mentioning

confidence: 99%

CT Features of Primary Graft Nonfunction after Liver Transplantation

Kim¹,

Kwon²,

Kim³

et al. 2016

Radiology

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Purpose To determine computed tomographic (CT) features of primary graft nonfunction (PNF) after liver transplantation in comparison with those of early graft failure or death by identifiable causes. Materials and Methods Institutional review board approval was obtained and informed consent was waived. Among 3947 adult liver transplantations performed in one institution between May 2002 and May 2015, 72 patients died or had graft failure within 10 days, and 38 of them were evaluated with CT. PNF was diagnosed in 21 patients. The other 17 patients who died or had early graft failure were considered the non-PNF control group. On unenhanced CT images, graft attenuation was compared qualitatively. Graft attenuation was measured quantitatively and, if available, the difference between preoperative and postoperative CT (interval change) attenuation was evaluated. Unenhanced CT was evaluated for relative parenchymal enhancement. Statistical analyses included the Fisher exact and χ tests with Yates correction and the Student t test. Results On unenhanced CT images, grafts with PNF more commonly showed low (eight of 26 [31%]) or extremely low (18 of 26 [69%]) qualitative attenuation compared with grafts in the non-PNF group (three of 21 [14%], one of 21 [5%]; P < .001). The mean attenuation value (30.5 HU ± 10.8) was significantly lower and the mean interval change (24.7 HU ± 12.5) was significantly higher in the PNF group than in the non-PNF group (49.7 HU ± 8.0 and 9.7 HU ± 10.1, respectively; P < .001 and P = .001). There was no significant difference in the proportion of grafts that showed poor enhancement on postcontrast CT images between the PNF group and the non-PNF group (nine of 24 [38%] vs two of 20 [10%], respectively; P = .08). Conclusion Recipients with PNF after liver transplantation tended to show low or extremely low attenuation on unenhanced CT images, and this finding was seen more frequently in patients with PNF than in those who died of identifiable causes and in those with early graft failure. RSNA, 2016 Online supplemental material is available for this article.

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“…"IIIa)" Maior"(IIIb". "V)" Não há tratamento específico, no entanto, parece estar relacionada a alguns fatores de risco como, idade avançada do doador 133,134 , enxerto com alto grau de esteatose [133][134][135] e tempo de isquemia prolongado 43,136,137 Apesar da discordância entre os estudos realizados, em relação a fatores de risco de morbimortalidade, a transfusão intraoperatória parece ser uma unanimidade, como fator determinante de mau prognóstico 56,92,93,146,147 .…”

Section: Classificação Das Complicações Pós-operatórias Deunclassified

Influência da transfusão de concentrado de hemácias na evolução pós-operatória de crianças submetidas a transplante hepático com doador vivo

Gordon¹

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Este trabalho é dedicado: Aos meus pais, Henry e Renata, que me ensinaram a importância do estudo, do respeito e da perseverança, guiando-me e incentivando-me, diariamente, desde a mais tenra infância. Ao meu esposo, José Antônio, por testemunhar as incontáveis horas de sacrifício e dedicação, por zelar pela família e por seu amor incondicional. Aos meus filhos, Mariana e Victor que, apesar do meu cansaço e impaciência frequentes, me compreenderam e me apoiaram até o fim. AGRADECIMENTOS A Deus, pela graça da vida, da saúde, da família, do amparo, da misericórdia, por me guiar nas horas incertas e me fortalecer perante às dificuldades, me fazendo realizar este sonho.

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Recipient and Perioperative Risk Factors Associated With Liver Transplant Graft Outcomes

Cited by 16 publications

References 16 publications

Primary graft dysfunction of the liver: definitions, diagnostic criteria and risk factors

Primary graft dysfunction of the liver: definitions, diagnostic criteria and risk factors

CT Features of Primary Graft Nonfunction after Liver Transplantation

Influência da transfusão de concentrado de hemácias na evolução pós-operatória de crianças submetidas a transplante hepático com doador vivo

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