Recognition control of the nucleic acid model through conformational switching of nucleobase induced by borate ester formation of cis-2',3'-diol

What transcriptomics and proteomics can tell us about a high borate perturbed boron tolerant Bacilli strain

“…Borates can impede base-pairing interactions by forming a reversible borate-ester complex via intramolecular hydrogen bonding at the cis-2 0 ,3 0 -diol of nucleoside sugars. 60 Borate can also disrupt protein function via two distinct reversible mechanisms. 61 The first replicates a high energy transition state structure by creating a covalent boronic acid tetrahedral adduct with the active site serine oxygen.…”

A G4·K+ hydrogel that self-destructs

“…S3, ESI †) and 2 0 ,3 0 -borate esters of nucleosides are known to favor the syn conformation. [29][30][31][32] Mass spectrometry and NMR spectroscopy confirmed that 5 0 -cG 3 was formed in situ when samples were heated to 90 1C. First, ESI-MS analysis (Fig.…”

Structural Preorganization of Peptide Nucleic Acids: Chiral Cationic Analogues with Five- or Six-Membered Ring Structures

“…[59] The strategy was actively to control the function of these oligomers through an external factor. The interconversion of the syn/anti nucleobase conformations of the ribonucleosides in PRNA with a free 2Ј,3Ј-diol system could be controlled by the formation of a borate ester.…”