Recognition memory reconsolidation requires hippocampal Zif268

Gonzalez, María Carolina; Rossato, Janine I.; Radiske, Andressa; Pádua-Reis, Marina; Cammarota, Martı́n

doi:10.1038/s41598-019-53005-8

Cited by 19 publications

(14 citation statements)

References 53 publications

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“…It has been reported that the memory reconsolidation process involves DNA transcription and de novo protein synthesis ( Nader et al, 2000 ; de la Fuente et al, 2015 ). DNA transcription is regulated by the epigenetic mechanisms of chromatin restructuring and DNA methylation, which play critical roles in the reconsolidation of memory ( Levenson and Sweatt, 2005 ; Duvarci et al, 2008 ; de la Fuente et al, 2015 ; Gonzalez et al, 2019 ; Liu et al, 2022 ). DNMT, a widely expressed DNA methylation enzyme in the mammalian adult nervous system ( Feng et al, 2005 ; Rahn et al, 2013 ), suppresses the transcription process by catalyzing the methylation of cytosine residues in DNA, causing the chromatin structure to compact and abolishing the transcription factors binding to the specific site of DNA ( Miller and Sweatt, 2007 ; Selvakumar et al, 2012 ; Lyko, 2018 ; Shi et al, 2021 ).…”

Section: Discussionmentioning

confidence: 99%

DNA methyltransferase activity in the basolateral amygdala is critical for reconsolidation of a heroin reward memory

Qian

Shi²,

Huang³

et al. 2022

Front. Mol. Neurosci.

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The persistence of drug memory contributes to relapse to drug seeking. The association between repeated drug exposure and drug-related cues leads to cravings triggered by drug-paired cues. The erasure of drug memories has been considered a promising way to inhibit cravings and prevent relapse. The re-exposure to drug-related cues destabilizes well-consolidated drug memories, during which a de novo protein synthesis-dependent process termed “reconsolidation” occurs to restabilize the reactivated drug memory. Disrupting reconsolidation of drug memories leads to the attenuation of drug-seeking behavior in both animal models and people with addictions. Additionally, epigenetic mechanisms regulated by DNA methyltransferase (DNMT) are involved in the reconsolidation of fear and cocaine reward memory. In the present study, we investigated the role of DNMT in the reconsolidation of heroin reward memory. In the heroin self-administration model in rats, we tested the effects of DNMT inhibition during the reconsolidation process on cue-induced reinstatement, heroin-priming-induced reinstatement, and spontaneous recovery of heroin-seeking behavior. We found that the bilateral infusion of 5-azacytidine (5-AZA) inhibiting DNMT into the basolateral amygdala (BLA) immediately after heroin reward memory retrieval, but not delayed 6 h after retrieval or without retrieval, decreased subsequent cue-induced and heroin-priming-induced reinstatement of heroin-seeking behavior. These findings demonstrate that inhibiting the activity of DNMT in BLA during the reconsolidation of heroin reward memory attenuates heroin-seeking behavior, which may provide a potential strategy for the therapeutic of heroin addiction.

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Section: Discussionmentioning

confidence: 99%

DNA methyltransferase activity in the basolateral amygdala is critical for reconsolidation of a heroin reward memory

Qian

Shi²,

Huang³

et al. 2022

Front. Mol. Neurosci.

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“…The hippocampus is also necessary for ORM reconsolidation, but only when recall occurs in the presence of a novel object ( 3 ). Indeed, presentation of a novel object during ORM recall activates the reconsolidation marker Zif268 ( 4 ) and is accompanied by a brief depotentiation period followed by a lasting increase in hippocampal synaptic efficacy ( 5 ). Moreover, the amnesia caused by ORM reconsolidation inhibitors is prevented by impairing novelty detection through hippocampal dopamine D1/D5 receptor blockade ( 6 ), suggesting that reconsolidation links the memory of the novel object to the reactivated recognition trace.…”

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confidence: 99%

Dopamine controls whether new declarative information updates reactivated memories through reconsolidation

Gonzalez

Rossato

Radiske

et al. 2021

Proc. Natl. Acad. Sci. U.S.A.

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Consolidation and reconsolidation are independent memory processes. Consolidation stabilizes new memories, whereas reconsolidation restabilizes memories destabilized when reactivated during recall. However, the biological role of the destabilization/reconsolidation cycle is still unknown. It has been hypothesized that reconsolidation links new information with reactivated memories, but some reports suggest that new and old memories are associated through consolidation mechanisms instead. Object-recognition memory (ORM) serves to judge the familiarity of items and is essential for remembering previous events. We took advantage of the fact that ORM consolidation, destabilization, and reconsolidation can be pharmacologically dissociated to demonstrate that, depending on the activation state of hippocampal dopamine D1/D5 receptors, the memory of a novel object presented during recall of the memory of a familiar one can be formed via reconsolidation or consolidation, but only reconsolidation can link them. We also found that recognition memories formed through reconsolidation can be destabilized even if indirectly reactivated. Our results indicate that dopamine couples novelty detection with memory destabilization to determine whether a new recognition trace is associated with an active network and suggest that declarative reminders should be used with caution during reconsolidation-based psychotherapeutic interventions.

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“…We presented the PyRAT, a library for animal tracking data analysis developed to be accessible to less experienced programmers. We implemented functions to infer common animal behavioral metrics used in the literature, such as object interaction (duration and number of interactions), traveled distance, speed, and time spent in different areas (Lima et al, 2009 ; Gonzalez et al, 2019 ; Rossato et al, 2019 ; Moura et al, 2020 ). Also, we implemented functions to infer animal behavior from tracked body parts in each frame using unsupervised approaches.…”

Section: Discussionmentioning

confidence: 99%

PyRAT: An Open-Source Python Library for Animal Behavior Analysis

Almeida¹,

Spinelli²,

Lima³

et al. 2022

Front. Neurosci.

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Here we developed an open-source Python-based library called Python rodent Analysis and Tracking (PyRAT). Our library analyzes tracking data to classify distinct behaviors, estimate traveled distance, speed and area occupancy. To classify and cluster behaviors, we used two unsupervised algorithms: hierarchical agglomerative clustering and t-distributed stochastic neighbor embedding (t-SNE). Finally, we built algorithms that associate the detected behaviors with synchronized neural data and facilitate the visualization of this association in the pixel space. PyRAT is fully available on GitHub: https://github.com/pyratlib/pyrat.

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Recognition memory reconsolidation requires hippocampal Zif268

Cited by 19 publications

References 53 publications

DNA methyltransferase activity in the basolateral amygdala is critical for reconsolidation of a heroin reward memory

DNA methyltransferase activity in the basolateral amygdala is critical for reconsolidation of a heroin reward memory

Dopamine controls whether new declarative information updates reactivated memories through reconsolidation

PyRAT: An Open-Source Python Library for Animal Behavior Analysis

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