Recombinant adenovirus p53 combined with radiotherapy improves efficacy and safety in the treatment of head and neck lymphoma

Whether the expression of gene P53 related with autophagy and apoptosis and action was regulated by miR-36b was discussed in our study. And the action of orienteering nano-particles on intervening invasion and metastasis of lymphoma was analyzed. The normal lymphoid tissue collected from the patients with simple lymphatic hyperplasia was set as control. The lymphoma samples from patients with early indolent lymphoma were collected. The level of mRNA in miR-36b and P53 was detected by PCR. The level of P53 protein and level of mRNA in miR-36b and P53 among normal lymphoid cell, cell strain of low metastatic lymphoma and cell strain of high metastatic lymphoma was compared. They were divided into four groups: miR-NC group, orienteering nano-particles’ group, siRNA-NC group and siRNA-P53 group. The cell proliferative capacity was detected by FCM. The quantity of cell invasion and metastasis was detected by transwell. The expression quantity of P53 mRNA in lymphoma tissue was increased obviously compared with control group. The expression of miR-36b was lower while the expression of P53 was higher along with the later staging of TNM. And the express was related with the staging of TNM. The expression quantity of P53 mRNA in lymphoma cell was higher in normal cell notably. But expression quantity of miR-36b in lymphoma cell was lower in normal cell notably. The decreased of expression of miR-36b and increased of expression of P53 was related with enhancing the ability of invasion and metastasis of lymphoma cells.

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From regulation to deregulation of p53 in hematologic malignancies: implications for diagnosis, prognosis and therapy

Ahmadi,

Rahimian,

Rahimi

et al. 2024

Biomark Res

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The p53 protein, encoded by the TP53 gene, serves as a critical tumor suppressor, playing a vital role in maintaining genomic stability and regulating cellular responses to stress. Dysregulation of p53 is frequently observed in hematological malignancies, significantly impacting disease progression and patient outcomes. This review aims to examine the regulatory mechanisms of p53, the implications of TP53 mutations in various hematological cancers, and emerging therapeutic strategies targeting p53. We conducted a comprehensive literature review to synthesize recent findings related to p53's multifaceted role in hematologic cancers, focusing on its regulatory pathways and therapeutic potential. TP53 mutations in hematological malignancies often lead to treatment resistance and poor prognosis. Current therapeutic strategies, including p53 reactivation and gene therapy, show promise in improving treatment outcomes. Understanding the intricacies of p53 regulation and the consequences of its mutations is essential for developing effective diagnostic and therapeutic strategies in hematological malignancies, ultimately enhancing patient care and survival.

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Recombinant adenovirus p53 combined with radiotherapy improves efficacy and safety in the treatment of head and neck lymphoma

Abstract: Altogether, we conclude that rAd-p53 combined with radiotherapy improves the efficacy and safety in treating head and neck lymphoma, which has a broad scope in future clinical application.

Cited by 3 publications

References 28 publications

Thymosin α1 reverses oncolytic adenovirus-induced M2 polarization of macrophages to improve antitumor immunity and therapeutic efficacy

Thymosin α1 reverses oncolytic adenovirus-induced M2 polarization of macrophages to improve antitumor immunity and therapeutic efficacy

The Mechanism of Nano-Particles Intervening Invasion and Metastasis of Lymphoma Based on Autophagy Targeted with miR-36b and Orienteering Analysis on Apoptosis Gene

From regulation to deregulation of p53 in hematologic malignancies: implications for diagnosis, prognosis and therapy

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