Recombinant Erdr1 suppresses the migration and invasion ability of human gastric cancer cells, SNU-216, through the JNK pathway

ERDR1 enhances human NK cell cytotoxicity through an actin-regulated degranulation-dependent pathway

“…ERDR1 induces hemoglobin synthesis and is a stressrelated survival factor [17,18]. Recently, ERDR1 was reported to be a pro-apoptotic factor in human keratinocytes and an antimetastasis factor in mouse melanoma cells and human gastric cancer cells [19][20][21]. This study investigated whether ERDR1 has anti-cancer effects on immune cells, human primary NK cells, as well as cancer cells.…”

“…The formation of the immunological synapse depends on actin modulation [15,16]. In human gastric cancer cells, ERDR1 affects the migration ability [21]. Thus, ERDR1 may affect NK cell migration and trafficking towards inflammatory regions.…”

“…Recently, ERDR1 expression is negatively regulated by IL-18, causing anti-metastatic functions in melanoma [20]. Additionally, ERDR1 inhibits gastric cancer cell migration and invasion [21]. ERDR1 is expressed in human keratinocytes and is detected in the cultured supernatants of murine erythroleukemia cells [17,19].…”

Microbiota promotes systemic T-cell survival through suppression of an apoptotic factor

“…Erdr1 is a vesicleassociated secreted protein that is ubiquitously expressed (11,15). It has reported functions in keratinocytes and NK cells, although there are currently no known roles for Erdr1 in T lymphocytes (13,14). A knockout mouse model does not exist to study the role of Erdr1, and our attempts to make a whole-body knockout using Crisper/Cas9 technology revealed that loss of this gene is not tolerated in utero ( Fig.…”

“…Erdr1 was originally identified in supernatants of B-cell leukemic cells and named for its hemoglobin-inducing activity on erythroid lines, but now has implicated roles in cellular survival, NK cytotoxicity, and metastasis; however, its function within T cells remains completely unexplored (11)(12)(13)(14)(15).…”