Recombinant Human Bone Morphogenetic Protein-2-Augmented Transforaminal Lumbar Interbody Fusion for the Treatment of Chronic Low Back Pain Secondary to the Homogeneous Diagnosis of Discogenic Pain Syndrome

Corenman, Donald S.; Gillard, Douglas M.; Dornan, Grant J.; Strauch, Eric D.

doi:10.1097/brs.0b013e31829fc56f

Cited by 13 publications

(19 citation statements)

References 53 publications

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“…Five studies [26, 27, 29, 36, 37] included data on the rate of return to work after OS surgery. Berg et al [36] reported on a clinical RCT comparing total disc replacement (TDR) and instrumented lumbar spinal fusion (i.e., PLF or PLIF) in Sweden.…”

Section: Resultsmentioning

confidence: 99%

“…Corenman et al [37] presented a small, 2 year retrospective observational study, where data were collected from a return to work questionnaire. The study found that 84.4% (27/32) of the cohort were able to return to the same job as before the surgery.…”

Section: Resultsmentioning

confidence: 99%

“…Overall, the studies focused on OS [26, 27, 29, 36, 37] including PLF, PLIF, and TLIF, as well as circumferential fusion techniques reported a greater variation of rate of return to work (range from 18% to 100%) within 3 months to 4 years compared to MIS studies.…”

Section: Resultsmentioning

confidence: 99%

“…TLIF was found to be the most frequently studied technique for lumbar spinal fusion operations regardless if MIS or OS was used. Twenty-seven studies described the position of the fusion or the number of levels that were fused for the study patients; out of which, nine studies [25–27, 31, 32, 37, 47, 56, 57] included patients who had two or more levels fused (range from 14% - 57% of total studied patients), but the results were not presented separately by fusion levels. Therefore, the current SLR mainly provides evidence of the time to return to work and the post-operation narcotic use for patients after a single-level lumbar spinal fusion.…”

Section: Discussionmentioning

confidence: 99%

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A systematic literature review of time to return to work and narcotic use after lumbar spinal fusion using minimal invasive and open surgery techniques

Wang¹,

Borgman

Vertuani³

et al. 2017

BMC Health Serv Res

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BackgroundChronic low back pain is a common health problem for adult workers and causes an enormous economic burden. With the improvement of minimally invasive surgical techniques (MIS) in spinal fusion and the development of fusion devices, more lumbar operations are today being performed through a less invasive technique. When compared with open surgeries (OS), MIS has demonstrated better clinical outcomes including operation time, blood loss, complication rates and length of hospital stay. The aim of this review was to identify and summarize evidence on the time to return to work and the duration of post-operation narcotic use for patients who had lumbar spinal fusion operations using MIS and OS techniques.MethodsA systematic literature review was performed including studies identified from PubMed, EMBASE, the Cochrane Collaboration, and the Centre for Review and Dissemination (CRD) (January 2004–April 2014) for publications reporting on time to return to work and post-operation narcotic use after MIS or OS lumbar spinal fusion surgeries.ResultsOut of a total of 36 included studies, 28 reported on the time to return to work and 17 on the narcotic use after MIS or OS. Four studies described the time to return to work directly comparing MIS and OS. Three studies, from the US, directly compared the duration of narcotic use between MIS- transforaminal lumbar interbody fusion (TLIF) and OS-TLIF. In addition to the time to return to work, 23 studies reported on the rate of return to work and the employment rate before and after surgery, and two Swedish studies presented sick leave data.ConclusionsThere is a gap of good quality data describing the time to return to work and narcotic use after lumbar spinal fusion operations using MIS or OS techniques. However, the current systematic literature review indicates that patients who have lumbar spinal fusion operations, with the MIS procedure, generally return to work after surgery more quickly and require less post-operation narcotics for pain control compared to patients who have OS.Electronic supplementary materialThe online version of this article (doi:10.1186/s12913-017-2398-6) contains supplementary material, which is available to authorized users.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

A systematic literature review of time to return to work and narcotic use after lumbar spinal fusion using minimal invasive and open surgery techniques

Wang¹,

Borgman

Vertuani³

et al. 2017

BMC Health Serv Res

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“…The proteins have been reported as good replacements of autologous bone graft in non-union, spine fusion and bone defect (Corenman et al, 2013;Moghaddam-Alvandi et al, 2012). However, rhBMP-2 is also known to cause soft tissue swelling, osteolysis and retrograde ejaculation by inducing ectopic bone formation, seroma formation and inflammation (Carragee et al, 2011;Helgeson et al, 2011;Smoljanovic et al, 2011).…”

Section: Introductionmentioning

confidence: 96%

Enhanced osteoinductivity of recombinant human bone morphogenetic protein-2 in combination with epidermal growth factor in a rabbit tibial defect model

et al. 2014

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This study aims to explore the effect of recombinant human bone morphogenetic protein-2 (rhBMP-2) on bone formation when treated with epidermal growth factor (EGF) using human mesenchymal stem cells (hMSCs) and a rabbit tibial defect model. The rhBMP-2 (250 ng/ml)+EGF (10 ng/ml) group showed higher alkaline phosphatase (ALP) activity, ALP expression, increased calcium amount than rhBMP-2 group. In micro-CT and histology results of animal experiments, the rhBMP-2+EGF group showed more amount of bone bridging compared to the rhBMP-2 group. Among the 8-week groups, the rhBMP-2+EGF group showed significantly higher percent bone volume and trabecular number compared to the rhBMP-2 group. The combined treatment with EGF and rhBMP-2 induced significantly higher bone formation compared to that of rhBMP-2 only in both hMSCs and a rabbit tibial defect model. Therefore, EGF is expected to facilitate bone formation effect of rhBMP-2 when both factors are treated in combination.

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What can we learn from long-term studies on chronic low back pain? A scoping review

et al. 2022

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Purpose A scoping review was conducted with the objective to identify and map the available evidence from long-term studies on chronic non-specific low back pain (LBP), to examine how these studies are conducted, and to address potential knowledge gaps. Method We searched MEDLINE and EMBASE up to march 2021, not restricted by date or language. Experimental and observational study types were included. Inclusion criteria were: participants between 18 and 65 years old with non-specific sub-acute or chronic LBP, minimum average follow-up of > 2 years, and studies had to report at least one of the following outcome measures: disability, quality of life, work participation, or health care utilization. Methodological quality was assessed using the Effective Public Health Practice Project quality assessment. Data were extracted, tabulated, and reported thematically. Results Ninety studies met the inclusion criteria. Studies examined invasive treatments (72%), conservative (21%), or a comparison of both (7%). No natural cohorts were included. Methodological quality was weak (16% of studies), moderate (63%), or strong (21%) and generally improved after 2010. Disability (92%) and pain (86%) outcomes were most commonly reported, followed by work (25%), quality of life (15%), and health care utilization (4%). Most studies reported significant improvement at long-term follow-up (median 51 months, range 26 months–18 years). Only 10 (11%) studies took more than one measurement > 2 year after baseline. Conclusion Patients with persistent non-specific LBP seem to experience improvement in pain, disability and quality of life years after seeking treatment. However, it remains unclear what factors might have influenced these improvements, and whether they are treatment-related. Studies varied greatly in design, patient population, and methods of data collection. There is still little insight into the long-term natural course of LBP. Additionally, few studies perform repeated measurements during long-term follow-up or report on patient-centered outcomes other than pain or disability.

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Recombinant Human Bone Morphogenetic Protein-2-Augmented Transforaminal Lumbar Interbody Fusion for the Treatment of Chronic Low Back Pain Secondary to the Homogeneous Diagnosis of Discogenic Pain Syndrome

Abstract: 4.

Cited by 13 publications

References 53 publications

A systematic literature review of time to return to work and narcotic use after lumbar spinal fusion using minimal invasive and open surgery techniques

A systematic literature review of time to return to work and narcotic use after lumbar spinal fusion using minimal invasive and open surgery techniques

Enhanced osteoinductivity of recombinant human bone morphogenetic protein-2 in combination with epidermal growth factor in a rabbit tibial defect model

What can we learn from long-term studies on chronic low back pain? A scoping review

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