Recombinant human chorionic gonadotropin (rhCG) in assisted reproductive technology: results of a clinical trial comparing two doses of rhCG (OvidrelR) to urinary hCG (ProfasiR) for induction of final follicular maturation in in vitro fertilization–embryo transfer

Chang, Peter L.; Kenley, Susan; Burns, Tammy L.; Denton, Geoff; Currie, Karen; DeVane, Gary W.; O’Dea, Louis

doi:10.1016/s0015-0282(01)01851-9

Cited by 97 publications

(62 citation statements)

References 11 publications

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“…the number of metaphase II oocytes [6], the numbers of fertilized oocytes and cleaved embryos were found to be significantly higher with 500 μg r-hCG [5].…”

Section: Introductionmentioning

confidence: 85%

“…Compared with 5,000 IU of u-hCG, a 250 μg dose of recombinant hCG (r-hCG) achieves similar clinical results [1][2][3] and has a similar pharmacokinetic profile [4]. Moreover, when doses of 500 μg and 250 μg of r-hCG were compared, although the mean number of oocytes retrieved was the same [5], as was Capsule After the administration of 250 mcg of recombinant hCG, plasma hCG levels are not responsible for failure to recover oocytes or for recovering a reduced number of oocytes.…”

Section: Introductionmentioning

confidence: 99%

“…This has been attributed to the following factors: empty follicles, technical difficulties with oocyte collection, ovulation occurring earlier than expected, and inaccurate hCG administration. Since hCG plasma levels depend on the hCG dose [5,6] and on body mass index (BMI) [9,10], it could be speculated that lower hCG levels could be associated with i) a higher rate of aspiration failure; and ii) a smaller number of oocytes being retrieved. Moreover, in IVF cycles after oocyte aspiration the number of oocytes obtained is sometimes much lower than expected and it could be that this is due to insufficiently high levels of hCG.…”

Section: Introductionmentioning

confidence: 99%

“…Previous studies focusing on hCG dose have used the total number of oocytes [1,2,5] or number of metaphase II oocytes retrieved as primary end points. We have also considered pregnancy rates, in order to assess any effect on implantation.…”

Section: Introductionmentioning

confidence: 99%

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Human chorionic gonadotropin (hCG) plasma levels at oocyte retrieval and IVF outcomes

Matorras

Meabe

Mendoza

et al. 2012

J Assist Reprod Genet

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Purpose The aim of our study was to ascertain the influence of hCG levels at oocyte pick-up on IVF outcomes, and their relationship with clinical parameters. Methods A prospective study was performed including 473 women undergoing IVF, aged under 40 years. Blood samples to analyze hCG levels were obtained at the time of follicular aspiration, 36 h after the administration of 250 μg of recombinant hCG.Results Neither the numbers of oocytes obtained or fertilized, nor the pregnancy rate, were correlated with hCG levels. Moreover, hCG values were very similar in women who did and did not become pregnant (123.3±48.7 and 117.5±44.7 mUI/mL). Cases in which no oocytes were recovered after follicular aspiration had similar hCG levels to those in which more than 1 oocyte was obtained. On the other hand, hCG levels were negatively related to body mass index, weight, and age. Conclusions These data indicate that after the administration of 250 μg of recombinant hCG, hCG levels are not responsible for failure to recover oocytes. Specifically, there was no correlation between plasma hCG levels and the number of oocytes obtained or other markers of IVF outcome. There was, however, an inverse relationship with BMI, body weight and age.

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“…the number of metaphase II oocytes [6], the numbers of fertilized oocytes and cleaved embryos were found to be significantly higher with 500 μg r-hCG [5].…”

Section: Introductionmentioning

confidence: 85%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Human chorionic gonadotropin (hCG) plasma levels at oocyte retrieval and IVF outcomes

Matorras

Meabe

Mendoza

et al. 2012

J Assist Reprod Genet

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show abstract

“…The efficacy of 250 µg r-hCG has been reported, and r-hCG has been shown to be well tolerated in the induction of final follicular maturation in women undergoing ART (4). Additionally, a dose of 250 µg r-hCG appears to be clinically equivalent to 10,000 IU u-hCG in this group (4).…”

Section: Introductionmentioning

confidence: 96%

A prospective, randomized and blinded comparison between 10,000 IU urinary and 250 μg recombinant human chorionic gonadotropin for oocyte maturation in in vitro fertilization cycles

Abdelmassih

Oliveira

Gonçalves

et al. 2005

J Assist Reprod Genet

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Submitted August 16, 2004; accepted December 20, 2004 Purpose : To compare the efficacy and safety of u-hCG with r-hCG in IVF cycles. Methods : A prospective, investigator-blind, randomized, comparative study. Patients (n = 100) ≤35 years with IVF indication were randomly assigned on the day of hCG administration for oocyte maturation to receive either u-hCG (10,000 IU) or r-hCG (250 µg). Results : No statistical differences were found between groups in relation to total number of oocytes retrieved, percentage of mature oocytes, number of injected oocytes, fertilization rates and number of embryos transferred. The data indicate a possible trend toward a higher incidence of pregnancy in the r-hCG group. Adverse events, predominantly injection-site reactions, were significantly more common in the u-hCG group. Conclusions : r-hCG is at least as effective for inducing final stages of oocyte maturation as 10,000 IU u-hCG and is also associated with significantly better patient tolerance and thus higher patient acceptability. KEY WORDS:In vitro fertilization; luteinizing hormone; oocyte maturation; recombinant human chorionic gonadotropin; urinary human chorionic gonadotropin.

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Recombinant versus urinary human chorionic gonadotrophin for final oocyte maturation triggering in IVF and ICSI cycles

Youssef¹,

Al-Inany²,

Aboulghar³

et al. 2005

Cochrane Database of Systematic Reviews

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Recombinant human chorionic gonadotropin (rhCG) in assisted reproductive technology: results of a clinical trial comparing two doses of rhCG (OvidrelR) to urinary hCG (ProfasiR) for induction of final follicular maturation in in vitro fertilization–embryo transfer

Cited by 97 publications

References 11 publications

Human chorionic gonadotropin (hCG) plasma levels at oocyte retrieval and IVF outcomes

Human chorionic gonadotropin (hCG) plasma levels at oocyte retrieval and IVF outcomes

A prospective, randomized and blinded comparison between 10,000 IU urinary and 250 μg recombinant human chorionic gonadotropin for oocyte maturation in in vitro fertilization cycles

Recombinant versus urinary human chorionic gonadotrophin for final oocyte maturation triggering in IVF and ICSI cycles

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