Recombinant human interleukin-11 (IL-11) is a protective factor in severe sepsis with thrombocytopenia: A case-control study

Wan, Bing; Zhang, Hao; Fu, Haiyan; Chen, Yikun; Yang, Liping; Yin, Jie; Wan, Yin; Shi, Yongqing

doi:10.1016/j.cyto.2015.08.001

Cited by 25 publications

(16 citation statements)

References 21 publications

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“…181 Recombinant IL-11 has been approved for the treatment of thrombocytopenia, a major dose-limiting hematologic complication of chemotherapy for cancer, 182 and recombinant human IL-11 is a protective factor in patients with severe sepsis with thrombocytopenia. 183…”

Section: Il-11mentioning

confidence: 99%

Interleukins (from IL-1 to IL-38), interferons, transforming growth factor β, and TNF-α: Receptors, functions, and roles in diseases

Akdiş

Aab

Altunbulakli

et al. 2016

Journal of Allergy and Clinical Immunology

722

617

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There have been extensive developments on cellular and molecular mechanisms of immune regulation in allergy, asthma, autoimmune diseases, tumor development, organ transplantation, and chronic infections during the last few years. Better understanding the functions, reciprocal regulation, and counterbalance of subsets of immune and inflammatory cells that interact through interleukins, interferons, TNF-α, and TGF-β offer opportunities for immune interventions and novel treatment modalities in the era of development of biological immune response modifiers particularly targeting these molecules or their receptors. More than 60 cytokines have been designated as interleukins since the initial discoveries of monocyte and lymphocyte interleukins (called IL-1 and IL-2, respectively). Studies of transgenic or gene-deficient mice with altered expression of these cytokines or their receptors and analyses of mutations and polymorphisms in human genes that encode these products have provided essential information about their functions. Here we review recent developments on IL-1 to IL-38, TNF-α, TGF-β, and interferons. We highlight recent advances during the last few years in this area and extensively discuss their cellular sources, targets, receptors, signaling pathways, and roles in immune regulation in patients with allergy and asthma and other inflammatory diseases.

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Section: Il-11mentioning

confidence: 99%

Interleukins (from IL-1 to IL-38), interferons, transforming growth factor β, and TNF-α: Receptors, functions, and roles in diseases

Akdiş

Aab

Altunbulakli

et al. 2016

Journal of Allergy and Clinical Immunology

722

617

View full text Add to dashboard Cite

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“…IL-11 is a member of the IL-6 family that also activates JAK/STAT3 signalling pathway through its binding to the IL-11Rα-gp130 complex. 66 IL-11 regulates the polarization of T cells 210 and downregulates pro-inflammatory cytokines, which are protective factors in other inflammatory diseases. 211,212 Many studies have shown IL-11 to be a protective cytokine and calculated the IL-11/IL-17 or IL-11/IL-1β ratios, which indicate the balance between pro- and anti-inflammatory cytokines.…”

Section: Other Anti-inflammatory Cytokines Involved In Periodontitismentioning

confidence: 99%

The cytokine network involved in the host immune response to periodontitis

2019

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Periodontitis is an inflammatory disease involving the destruction of both soft and hard tissue in the periodontal region. Although dysbiosis of the local microbial community initiates local inflammation, over-activation of the host immune response directly activates osteoclastic activity and alveolar bone loss. Many studies have reported on the cytokine network involved in periodontitis and its crucial and pleiotropic effect on the recruitment of specific immunocytes, control of pathobionts and induction or suppression of osteoclastic activity. Nonetheless, particularities in the stimulation of pathogens in the oral cavity that lead to the specific and complex periodontal cytokine network are far from clarified. Thus, in this review, we begin with an up-to-date aetiological hypothesis of periodontal disease and summarize the roles of cytokines in the host immune response. In addition, we also summarize the latest cytokine-related therapeutic measures for periodontal disease.

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“…Yet, LIF-deficient mice have enhanced mortality in a similar model, and LIF injections improve the liver pathology (Weber et al, 2005). Additionally, recombinant IL-11 therapy reduces mortality in patients with sepsis (Wan et al, 2015), CT-1 injections attenuate endotoxin-induced lung injury in rats (Pulido et al, 1999), and mortality is enhanced in mice with myeloid-lineage-specific gp130 deletion (Sackett et al, 2019).…”

Section: Regulation Of Il-6 Family Cytokine Expressionmentioning

confidence: 99%