Recombinant interferon gamma therapy for atopic dermatitis

Hanifin, Jon M.; Schneider, Lynda C.; Leung, Donald Y.M.; Ellis, Charles N.; Jaffe, Howard S.; Izu, Allen; Bucalo, L. R.; Hirabayashi, Sue E.; Tofte, Susan J.; Cantu-Gonzales, Graciela; Milgrom, Henry; Boguniewicz, Mark; Cooper, Kevin D.

doi:10.1016/0190-9622(93)70026-p

Cited by 280 publications

(161 citation statements)

References 23 publications

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“…AD patients usually have a family history, hypersensitivity to certain Ags and high levels of serum IgE (1,2). Previous studies suggested that the reduced IFN-␥ production with the concurrent up-regulation of IL-4 induces the hyperproduction of IgE and AD (3)(4)(5), and several clinical trials suggested that IFN-␥ therapy was found to improve AD symptoms (6,7). However, the mechanism of the cytokine imbalance in atopic dermatitis patients remains to be elucidated.…”

Section: A Topic Dermatitis (Ad)mentioning

confidence: 99%

The Mechanism of a Defective IFN-γ Response to Bacterial Toxins in an Atopic Dermatitis Model, NC/Nga Mice, and the Therapeutic Effect of IFN-γ, IL-12, or IL-18 on Dermatitis

Habu

Seki²,

Takayama³

et al. 2001

The Journal of Immunology

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NC/Nga (NC) mice raised under conventional conditions (Conv. NC mice) spontaneously develop dermatitis similar to human atopic dermatitis, whereas NC mice raised under the specific pathogen-free conditions do not develop dermatitis. In the present study, we show that the representative Th1 cytokine, IFN-γ levels in the sera of NC mice, injected with either staphylococcal enterotoxin B or endotoxin (LPS), to be severalfold lower than those of normal mice. The low IFN-γ response to staphylococcal enterotoxin B was correlated to the lack of regular Vβ8+ T cells and Vβ8+ NK T cells, and the low IFN-γ response to LPS was correlated to an impaired IL-18 production of macrophages. The CD3-stimulated IL-4 production from liver and spleen T cells from Conv. NC mice in vitro was greatly augmented. The serum IL-4 levels of untreated Conv. NC mice also were higher than those of normal mice and specific pathogen-free NC mice. Treatment of Conv. NC mice either with IFN-γ, IL-12, or IL-18 twice a week from 4 wk of age substantially inhibited the elevation of the serum IgE levels, serum IL-4 levels, and dermatitis, and IL-12 or IL-18 treatment also reduced the in vitro IL-4 production from CD3-stimulated liver T cells. The systemic deficiency in the Th1 response to bacterial stimulation thus leads to a Th2-dominant state and may induce an abnormal cellular immune response in the skin accompanied with an overproduction of IgE and a susceptibility to dermatitis in NC mice.

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Section: A Topic Dermatitis (Ad)mentioning

confidence: 99%

The Mechanism of a Defective IFN-γ Response to Bacterial Toxins in an Atopic Dermatitis Model, NC/Nga Mice, and the Therapeutic Effect of IFN-γ, IL-12, or IL-18 on Dermatitis

Habu

Seki²,

Takayama³

et al. 2001

The Journal of Immunology

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“…Was investigated for use in atopic dermatitis due to its pathological dysregulation, and was found to be effective in short term (Hanifin et al, 1993) and long term studies (Stevens et al, 1998). However, its low response rate and high costs deter its regular use and implementation.…”

Section: Interferon γmentioning

confidence: 99%

Natural Products and Dermatological Hypersensitivity Diseases

MacDonald¹,

Kulka²

2012

Allergic Diseases - Highlights in the Clinic, Mechanisms and Treatment

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“…Interferon-gamma (IFN-gamma) has shown varying results in the treatment of severe atopic dermatitis although a couple of trials have shown a reduction in symptoms and body surface involvement (Hanifin et al 1993). Side effects that may occur include granulocytopenia, fever/chills, myalgias, headache, and inject site pain.…”

Section: Interferonsmentioning

confidence: 99%