Recombinant Leucocyte Interferon a Induces Steroid-Resistant Acute Vascular Rejection Episodes in Renal Transplant Recipients

Kramer, P.; Bijnen, A. B.; Kate, F. W. J. Ten; Jeekel, J.; Weimar, Willem

doi:10.1016/s0140-6736(84)92327-4

Cited by 115 publications

(41 citation statements)

References 9 publications

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“…In the past, 'acute vascular rejection' has been described in patients receiving IFN, but it could not be determined whether this represented AHR as no testing for DSA in serum or immuno-staining for C4d deposits in biopsies were performed (9,10,12). In view of our findings, it can be speculated that these cases may also have been AHR.…”

Section: Discussionmentioning

confidence: 63%

“…In most patients IFN is not used, as it has been associated with triggering severe acute allograft rejection (7,8). An incidence of acute rejection varying from 15% to 64% has been reported after starting therapy with IFN (7)(8)(9)(10)(11)(12)(13). Other reports, however, have not documented allograft dysfunction after treatment with IFN in renal transplant recipients (14)(15)(16).…”

Section: Introductionmentioning

confidence: 99%

“…The exact mechanism of acute rejection triggered by IFN is not clear. Suggested inciting pathways include increased cell surface expression of HLA alloantigens and induction of cytokine gene expression by IFN, or enhancement of antibody production by B cells (9,17,18). Of note, irreversible graft loss due to rejection has been reported (9,10,12,13), but evaluation of humoral responses by repeat crossmatches or staining of biopsies for C4d was not undertaken.…”

Section: Introductionmentioning

confidence: 99%

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Acute Humoral Rejection in Hepatitis C‐Infected Renal Transplant Recipients Receiving Antiviral Therapy

Baid

Tolkoff-Rubin

Saidman

et al. 2003

American Journal of Transplantation

120

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The use of interferon-alpha (IFN) in hepatitis C (HCV)-infected renal recipients has been associated with acute rejection and graft loss. We reviewed our recent experience in HCV (π) renal recipients treated with antiviral therapy for biopsy proven chronic hepatitis C. Twelve HCV (π) recipients who recently received antiviral therapy were analyzed. Post-treatment sera were tested for donor-specific human leukocyte antigen (HLA) antibodies (DSA). Within 6 months of initiating antiviral therapy, two of 12 patients (17%) developed acute rejection, which was characterized as acute humoral rejection (de novo DSA in serum and C4d deposits in peritubular capillaries). Both progressed to graft failure. Nine of the remaining 10 patients tested did not have DSA. The use of IFN was associated with severe acute humoral rejection (C4d π, DSA π). The recognition of IFN-associated acute humoral rejection in this series may explain the high rate of graft loss reported previously in renal recipients receiving IFN.

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Section: Discussionmentioning

confidence: 63%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Acute Humoral Rejection in Hepatitis C‐Infected Renal Transplant Recipients Receiving Antiviral Therapy

Baid

Tolkoff-Rubin

Saidman

et al. 2003

American Journal of Transplantation

120

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“…There is no reason, however, to deny the inherent ability of IFN-␣ to tip the scales toward rejection. This has been well documented in experimental models 21 and by reports of the devastating complications of IFN-␣ therapy in human kidney transplant recipients, 22,23 including some of our own patients. 24 The most obvious explanation for the disparity in outcome with liver and kidney transplantation derives from the retarded metabolism of tacrolimus 29,30 and, to a lesser degree, CyA, that occurs with the hepatic dysfunction that is a frequent finding in the post-OLT population, especially so with the supervention of hepatitis.…”

Section: Acute Allograft Rejection and Alfa Interferonmentioning

confidence: 68%

Incidence and severity of acute allograft rejection in liver transplant recipients treated with alfa interferon

et al. 1998

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“…type I interferon) or by antiviral T lymphocytes (IFN-7, TNF-~). Inflammation in response to viral infection may represent a direct link that also increases the extent of mH peptide presentation in uninfected cells (De Bueger et al, 1992), leading to a break in T cell tolerance, allograft rejection and graftversus-host disease (Krammer et al, 1984).…”

Section: Discussionmentioning

confidence: 99%

Cytokines restore MHC class I complex formation and control antigen presentation in human cytomegalovirus-infected cells

Hengel

Esslinger

Pool

et al. 1995

Journal of General Virology

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CD8 + cytotoxic T cell (CTL) clones with specificity for defined minor and major histocompatibility (H) antigens were used to monitor antigen presentation in human cytomegalovirus (HCMV)-infected skin fibroblasts. At the immediate early stage of virus replication antigen presentation was intact, but was abolished during the early and late phase. Lack of CTL recognition was not selective for certain antigens but was associated with decreased steady state levels of nascent MHC class I complexes and unassembled MHC class I heavy chains, whereas free fl2-microglobulin remained abundant. HCMV also affected the stability of both immature endoglycosidase H (Endo H)-sensitive and mature Endo H-resistant MHC class I molecules, suggesting that the virus interferes with antigen presentation at more than one step during maturation of the MHC class I complex. The action of interferon-y (IFN-7) and tumour necrosis factor-~ (TNF-~) lifted the block of MHC class I complex formation by stimulating synthesis, assembly and stability of MHC class I molecules. This resulted in restored antigen presentation provided that cells were exposed to the factors before HCMV infection. Because few MHC molecules suffice for CTL recognition these cytokines compensated for the negative viral effect on the antigen presentation function. Nevertheless, the viral interference with MHC class I complex formation was still active. The data imply that specific cytokines limit the immune evasion potential of HCMV from CD8 + T lymphocyte control.

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Recombinant Leucocyte Interferon a Induces Steroid-Resistant Acute Vascular Rejection Episodes in Renal Transplant Recipients

Cited by 115 publications

References 9 publications

Acute Humoral Rejection in Hepatitis C‐Infected Renal Transplant Recipients Receiving Antiviral Therapy

Acute Humoral Rejection in Hepatitis C‐Infected Renal Transplant Recipients Receiving Antiviral Therapy

Incidence and severity of acute allograft rejection in liver transplant recipients treated with alfa interferon

Cytokines restore MHC class I complex formation and control antigen presentation in human cytomegalovirus-infected cells

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