Recombinant luteinizing hormone induces increased production of ovarian follicular adiponectin in vivo: implications for enhanced insulin sensitivity

Adiponectin increases insulin-like growth factor I-induced progesterone and estradiol secretion in human granulosa cells

“…In the present study, we confirmed the presence of adiponectin in the human FF (28,36). Adiponectin is also detected in the small, medium, and large porcine follicles at concentrations similar to those found in serum (24).…”

“…In women, a recent study demonstrated that LH supplementation during the late follicular phase induces increased production of ovarian follicle adiponectin, suggesting a secretion by human thecal cells. However, the effect of LH supplementation on adiponectin plasma concentration was not indicated (28). In a previous study, we observed that adiponectin was expressed in rat theca-interstitial cells, corpus luteum (CL), and oocytes but not in GCs, in good correlation with results observed in humans.…”

“…Adiponectin levels have been measured in porcine and human follicular fluid (FF) (24). In human, recombinant LH induces in vivo increased production of adiponectin in FF (28).…”

The impact of adipose tissue-derived factors on the hypothalamic-pituitary-gonadal (HPG) axis

“…20 LH administration in vivo during the late follicular phase induces adiponectin in follicular fluids, decreases androgen levels and increases ovarian sensitivity to insulin. 60 The expression of adiponectin receptors is also identified in GH-, FSH-, LH-and TSH-producing cells in the pars distalis but not in the pars tuberalis. Moreover, AdipoR1 are detectable in lateral hypothalamic neurons and on the nucleus basalis.…”

Adiponectine et résistine

“…Dans la lignée de granulosa humaine KGN, l'inactivation spé-cifique d'AdipoR1 et d'AdipoR2 montre qu'AdipoR1 est impliqué dans la survie cellulaire, alors qu'AdipoR2 est préférentiellement impliqué dans la stéroïdogenèse [26]. En 2008, Gutman et al [27] ont montré une augmentation de la concentration de l'adiponectine dans le liquide folliculaire en réponse aux gonadotropines ovariennes après administration de LH recombinante. Chez la vache, l'adiponectine diminue in vitro la Chez cette espèce, plusieurs polymorphismes des gènes codant pour l'adiponectine et ses deux récepteurs ont été identifiés.…”