Recombinant Viral Vectors for Investigating DNA Damage Responses and Gene Therapy of Xeroderma Pigmentosum

Os papéis específicos das fotolesões de DNA CPDs e 6-4PPs em respostas epiteliais distintas à irradiação ultravioleta em camundongos deficientes em reparo de DNA.

“…Later the same group showed that these T4N5 liposomes can be delivered through the skin in a 1 % hydrogel lotion, efficiently removing CPD lesions present in the epidermis and consequently reducing UV-induced mutagenesis. Clinical trials showed that this enzyme was efficient in XP patients, reducing 30 % of the BCC rate, reviewed in (121). A sunscreen with enveloped T4 endo V is now being produced by a Japanese company (Synergy Worldwide) and is sold in some countries.…”