Recommendation on the technical and dosimetric data to be included in stereotactic body radiation therapy clinical trial publications based on a systematic review

Hardcastle, Nicholas; Josipovic, Mirjana; Clementel, Enrico; Hernandez, Victor; Smyth, Gregory; Gober, Manuela; Wilke, Lotte; Eaton, David; Josset, Stéphanie; Lazarakis, Smaro; Saez, Jordi; Vieillevigne, Laure; Jornet, Núria; Mancosu, Pietro

doi:10.1016/j.radonc.2023.110042

Radiotherapy and Oncology

2024

DOI: 10.1016/j.radonc.2023.110042

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Recommendation on the technical and dosimetric data to be included in stereotactic body radiation therapy clinical trial publications based on a systematic review

Nicholas Hardcastle,

Mirjana Josipovic,

Enrico Clementel

et al.

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Cited by 3 publications

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Optimal hypofractionated radiation therapy schemes for early-stage hepatocellular carcinoma

Liu,

Brown,

Munley

2024

Radiotherapy and Oncology

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Optimal hypofractionated radiation therapy schemes for early-stage hepatocellular carcinoma

Liu,

Brown,

Munley

2024

Radiotherapy and Oncology

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Lung sparing in MR-guided non-adaptive SBRT treatment of peripheral lung tumors

Lee,

Ferguson

et al. 2024

Biomed. Phys. Eng. Express

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Objective. We aim to: (1) quantify the benefits of lung sparing using non-adaptive magnetic resonance guided stereotactic body radiotherapy (MRgSBRT) with advanced motion management for peripheral lung cancers compared to conventional x-ray guided SBRT (ConvSBRT); (2) establish a practical decision-making guidance metric to assist a clinician in selecting the appropriate treatment modality. Approach. Eleven patients with peripheral lung cancer who underwent breath-hold, gated MRgSBRT on an MR-guided linear accelerator (MR linac) were studied. Four-dimensional computed tomography (4DCT)-based retrospective planning using an internal target volume (ITV) was performed to simulate ConvSBRT, which were evaluated against the original MRgSBRT plans. Metrics analyzed included planning target volume (PTV) coverage, various lung metrics and the generalized equivalent unform dose (gEUD). A dosimetric predictor for achievable lung metrics was derived to assist future patient triage across modalities. Main results. PTV coverage was high (median V100% > 98%) and comparable for both modalities. MRgSBRT had significantly lower lung doses as measured by V20 (median 3.2% versus 4.2%), mean lung dose (median 3.3 Gy versus 3.8 Gy) and gEUD. Breath-hold, gated MRgSBRT resulted in an average reduction of 47% in PTV volume and an average increase of 19% in lung volume. Strong correlation existed between lung metrics and the ratio of PTV to lung volumes (RPTV/Lungs) for both modalities, indicating that RPTV/Lungs may serve as a good predictor for achievable lung metrics without the need for pre-planning. A threshold value of RPTV/Lungs < 0.035 is suggested to achieve V20 < 10% using ConvSBRT. MRgSBRT should otherwise be considered if the threshold cannot be met. Significance. The benefits of lung sparing using MRgSBRT were quantified for peripheral lung tumors; RPTV/Lungs was found to be an effective predictor for achievable lung metrics across modalities. RPTV/Lungs can assist a clinician in selecting the appropriate modality without the need for labor-intensive pre-planning, which has significant practical benefit for a busy clinic.

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Stereotactic Radiation Therapy Planning, Dose Prescription and Delivery in Veterinary Medicine: A Systematic Review on Completeness of Reporting and Proposed Reporting Items

Rohrer Bley,

Meier,

Turek

et al. 2024

Vet Comparative Oncology

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Increasing numbers of dogs and cats with cancer are treated with stereotactic radiosurgery, stereotactic radiation therapy or stereotactic body radiotherapy (SRS, SRT or SBRT). We provide a systematic review of the current data landscape with a focus on technical and dosimetric data of stereotactic radiotherapy in veterinary oncology. Original peer‐reviewed articles on dogs and cats with cancer treated with SRT were included. The systematic search included Medline via PubMed and EMBASE. The study was performed according to the Preferred Reporting Items for Systematic Reviews (PRISMA) statement. We assessed the manuscripts regarding outcome reporting, treatment planning, dose prescription, ‐delivery and ‐reporting as well as quality assurance. As of February 2024, there are 80 peer‐reviewed publications on various disease entities on SRS, SRT and SBRT in veterinary medicine. Overall, we found often insufficient or highly variable technical data, with incomplete information to reproduce these treatments. While in some instances, technical factors may not impact clinical outcome, the variability found in protocols, outcome and toxicity assessments precludes accurate and reliable conclusions for a benefit of stereotactic radiotherapy for many of the treated diseases. In line with the extensive recommendations from human stereotactic radiotherapy practise, we propose a draft of reporting items for future stereotactic radiation treatments in veterinary medicine. SRS, SRT and SBRT have specific clinical and technological requirements that differ from those of standard radiation therapy. Therefore, a deep understanding of the methodologies, as well as the quality and precision of dose delivery, is essential for effective clinical knowledge transfer.

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Recommendation on the technical and dosimetric data to be included in stereotactic body radiation therapy clinical trial publications based on a systematic review

Cited by 3 publications

References 33 publications

Optimal hypofractionated radiation therapy schemes for early-stage hepatocellular carcinoma

Optimal hypofractionated radiation therapy schemes for early-stage hepatocellular carcinoma

Lung sparing in MR-guided non-adaptive SBRT treatment of peripheral lung tumors

Stereotactic Radiation Therapy Planning, Dose Prescription and Delivery in Veterinary Medicine: A Systematic Review on Completeness of Reporting and Proposed Reporting Items

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