Recommendations for physical activity and exercise in persons living with Systemic Lupus Erythematosus (SLE): consensus by an international task force

Blaess, Julien; Geneton, Sophie; Goepfert, Thibaut; Appenzeller, Simone; Bordier, Gabriel; Davergne, Thomas; Fuentes, Yurilis; Haglo, Håvard; Hambly, Karen; Kinnett-Hopkins, Dominique; Su, Kuei-Ying; Legge, Alexandra; Li, Linda; Mak, Anselm; Padjen, Ivan; Sciascia, Savino; Sheikh, Saira Z; Soriano-Maldonado, Alberto; Ugarte-Gil, Manuel F; Md Yusof, Md Yuzaiful; Parodis, Ioannis; Arnaud, Laurent

doi:10.1136/rmdopen-2024-004171

Cited by 1 publication

(1 citation statement)

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“…According to Blaess et al, integrating safe and specific exercises tailored to the patient's disease severity, comorbidities and overall health can significantly improve health outcomes, helping patients with SLE to lead an active and healthier life. 18 The strengths of this study include the availability of a large and well-characterised population with SLE and the detailed use of sarcopenia and clinical features, immunological parameters and demographic data. However, our study has several limitations.…”

Section: Immunology and Inflammationmentioning

confidence: 99%

Frequency of sarcopenia in Turkish women with systemic lupus erythematosus

Bilici,

Candemir,

Satış

et al. 2024

Lupus Sci Med

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ObjectiveThis study aimed to evaluate the prevalence of sarcopenia and its clinical significance in Turkish women with SLE, exploring the association between muscle mass, muscle strength and SLE disease activity.MethodsA cross-sectional study was conducted at Gazi University Hospital’s Department of Rheumatology from January to December 2020. It involved 82 patients with SLE, diagnosed according to the 2019 American College of Rheumatology/European Alliance of Associations for Rheumatology criteria, and 69 healthy controls. Sarcopenia was assessed using hand grip dynamometry (hand grip strength (HGS)) and bioelectrical impedance analysis for muscle mass, with sarcopenia defined according to the 2018 European Working Group on Sarcopenia in Older People criteria and specific cut-offs for the Turkish population. The main outcomes measured were the presence of sarcopenia and probable sarcopenia, HGS values, skeletal muscle mass index and SLE Disease Activity Index 2000 (SLEDAI-2K).ResultsAmong the patients with SLE, 51.2% met the criteria for probable sarcopenia and 12.9% were diagnosed with sarcopenia. The mean HGS was significantly lower in the SLE group (21.7±4.9 kg) compared with controls, indicating reduced muscle strength. The prevalence of anti-double-stranded DNA (anti-dsDNA) antibodies was 82.9%. Multivariate regression analysis identified height and levels of anti-dsDNA antibodies as independent predictors for developing probable sarcopenia. No significant association was found between clinical parameters, including SLEDAI-2K scores, and sarcopenia status.ConclusionsSarcopenia is prevalent among Turkish women with SLE, with a significant proportion showing reduced muscle strength. The study found no direct association between sarcopenia and SLE disease activity or clinical parameters. These findings underscore the importance of including muscle strength assessments in the routine clinical evaluation of patients with SLE to potentially improve management and quality of life.

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Section: Immunology and Inflammationmentioning

confidence: 99%