Recommendations for rosacea diagnosis, classification and management: update from the global
            <scp>ROS</scp>
            acea
            <scp>CO</scp>
            nsensus 2019 panel

Schaller, Martin; Almeida, Luiz Maurício Costa; Bewley, Anthony; Cribier, B.; Rosso, James Del; Dlova, Ncoza C.; Gallo, Richard L.; Granstein, Richard D.; Kautz, G.; Mannis, Mark J.; Micali, Giuseppe; Oon, Hazel H; Rajagopalan, Murlidhar; Steinhoff, Martin; Tanghetti, Emil; Thiboutot, Diane; Troielli, Patricia; Webster, Guy F.; Zierhut, Manfred; Zuuren, Esther J van; Tan, Jerry

doi:10.1111/bjd.18420

Cited by 152 publications

(239 citation statements)

References 23 publications

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“…Meanwhile, based on clinical features, subtypes include erythematotelangiectatic rosacea (ETR), papulopustular rosacea (PPR), phymatous rosacea (PhR)/rhinophyma, and ocular rosacea. More recently, the term "phenotype, " describing a person's observable characteristics that can be influenced by environmental or genetic factors, was proposed due to the range of manifestations of the multiple subtypes and progression between subtypes (3,4). The diverse and overlapping clinical manifestations of rosacea have a significant psychological impact on patients, causing self-abasement, depression, anxiety, and social phobia (5).…”

Section: Introductionmentioning

confidence: 99%

The Theranostics Role of Mast Cells in the Pathophysiology of Rosacea

Wang

Hao

et al. 2020

Front. Med.

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Rosacea is a chronic inflammatory cutaneous disorder that adversely affects patient's health and quality of life due to the complex course and the need for repeated treatment. The exact molecular mechanisms of rosacea are unclear. Mast cells are innate immune cells that can be found in virtually all tissues. Recently, increasing evidence has indicated that mast cells have important effects on the pathogenesis of rosacea. In this review article, we describe recent advances of skin mast cells in the development of rosacea. These studies suggested that mast cells can be an important immune cell that connected innate immunity, nerves, and blood vessels in the development of rosacea. Moreover, we review the inhibition of mast cells for the potential treatment of rosacea.

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Section: Introductionmentioning

confidence: 99%

The Theranostics Role of Mast Cells in the Pathophysiology of Rosacea

Wang

Hao

et al. 2020

Front. Med.

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“…To guarantee adequate evaluation of rosacea severity, clinical assessment was performed using multiple scales, based on the newly developed phenotype-based classification system for rosacea (31,36,42). Topical ivermectin treatment reduced the number of facial inflammatory lesions and erythema, with the greatest reduction at week 16.…”

Section: Discussionmentioning

confidence: 99%

Value of reflectance confocal microscopy for the monitoring of rosacea during treatment with topical ivermectin

Logger

Peppelman²,

Erp

et al. 2020

Journal of Dermatological Treatment

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Background: Reflectance confocal microscopy (RCM) enables noninvasive Demodex mite detection in rosacea. Objective scoring of rosacea severity is currently lacking. Objectives: To determine the value of RCM for monitoring Demodex, inflammation and vascular parameters in rosacea during treatment. Methods: In 20 rosacea patients, clinical and RCM examination were performed before, during, and 12 weeks after a 16-week treatment course with topical ivermectin. Using RCM, number of mites and inflammatory cells, epidermal thickness, and vascular density and diameter were measured. RCM features were correlated with clinical assessment. Results: Treatment resulted in clinical reduction of inflammatory lesions. Mites were detected in 80% of patients at baseline, 30% at week 16, and 63% at week 28. The number of mites reduced significantly during treatment, but no changes in inflammatory cells, epidermal thickness or vascular parameters were observed. Correlation between number of inflammatory lesions and mites was low. None of the RCM variables were significant predictors for clinical success. Conclusions: RCM enables anti-inflammatory effect monitoring of topical ivermectin by determining mite presence. Quantifying exact mite number, and inflammatory and vascular characteristics is challenging due to device limitations. In its current form, RCM seems of limited value for noninvasive follow-up of rosacea in clinical practice.

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“…If these findings are missing, two or more major features can be used for the diagnosis, namely papules and pustules, flushing (transient erythema), and telangiectasia. Minor features such as burning or stinging sensation, facial edema, and dry appearance can also contribute to diagnosis 4 . Apart from these cutaneous findings, ocular manifestation should not be overlooked 5 …”

Section: Introductionmentioning

confidence: 99%

“…Therefore, a skin care regime suitable and specific for sensitive skin prone to redness should be used on a daily basis. Cleansing products that can be applied and removed without the use of water are preferred 4 . Topicals should be moisturizing and contain a light texture and sun protection factor 18 .…”

Section: Introductionmentioning

confidence: 99%

Efficacy and safety results of micellar water, cream and serum for rosacea in comparison to a control group

Guertler

Jøntvedt

Clanner‐Engelshofen

et al. 2020

J of Cosmetic Dermatology

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Background Rosacea is a common inflammatory skin disorder with centrofacial erythema, flushing, telangiectasia, papules/pustules, and possible ocular or phymatous manifestation. Patients’ skin is particularly sensitive to chemical and physical stimuli leading to burning, stinging, dryness, and skin tightness. Objective Dermatological evaluation of the efficacy and safety of skin care products designed for centrofacial erythema in rosacea patients, in comparison with a control group using objective measurements. Rosacea symptoms (itching, tension, warmth, burning, dryness) and quality of life were examined. Methods Sixty Caucasians with centrofacial erythema were enrolled in an 8‐week prospective study, fifty of them exclusively using the study products (micellar water, cream, and serum) with ten participants randomly assigned to a control group. Patients were evaluated at baseline (V0), at 4 weeks (V1), and at 8 weeks (V2). Three‐dimensional objective measurements (VECTRA®) as well as standardized questionnaires were used. Results Results were compared with the control group. A significant reduction of 16% in skin redness as indicated by VECTRA® analysis was seen in the intervention group comparing V0‐V2. Furthermore, rosacea‐associated symptoms diminished by 57.1%, while life quality of affected patients within the intervention group improved by 54.5% comparing V0‐V2, respectively. Conclusions A skin care regime suitable for sensitive and redness‐prone skin led to an enhanced clinical appearance, to a decrease of associated symptoms in rosacea patients, and to an improved life quality.

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Recommendations for rosacea diagnosis, classification and management: update from the global ROS acea CO nsensus 2019 panel

Abstract: This summary relates to: https://doi.

Cited by 152 publications

References 23 publications

The Theranostics Role of Mast Cells in the Pathophysiology of Rosacea

The Theranostics Role of Mast Cells in the Pathophysiology of Rosacea

Value of reflectance confocal microscopy for the monitoring of rosacea during treatment with topical ivermectin

Efficacy and safety results of micellar water, cream and serum for rosacea in comparison to a control group

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